From Wikipedia, the free encyclopedia
White matter
Grey matter and white matter - very high mag.jpg
Micrograph showing white matter with its characteristic fine meshwork-like appearance (left of image – lighter shade of pink) and grey matter, with the characteristic neuronal cell bodies (right of image – dark shade of pink). HPS stain.
Human brain right dissected lateral view description.JPG
Human brain right dissected lateral view, showing grey matter (the darker outer parts), and white matter (the inner and prominently whiter parts).
Location Central nervous system
Latinsubstantia alba
MeSH D066127
TA98 A14.1.00.009
TA2 5366
FMA 83929
Anatomical terminology
White matter structure of human brain (taken by MRI).

White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, also called tracts. [1] Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distribution of action potentials, acting as a relay and coordinating communication between different brain regions. [2]

White matter is named for its relatively light appearance resulting from the lipid content of myelin. However, the tissue of the freshly cut brain appears pinkish-white to the naked eye because myelin is composed largely of lipid tissue veined with capillaries. Its white color in prepared specimens is due to its usual preservation in formaldehyde.


White matter

White matter is composed of bundles, which connect various grey matter areas (the locations of nerve cell bodies) of the brain to each other, and carry nerve impulses between neurons. Myelin acts as an insulator, which allows electrical signals to jump, rather than coursing through the axon, increasing the speed of transmission of all nerve signals. [3]

The total number of long range fibers within a cerebral hemisphere is 2% of the total number of cortico-cortical fibers (across cortical areas) and is roughly the same number as those that communicate between the two hemispheres in the brain's largest white tissue structure, the corpus callosum. [4] Schüz and Braitenberg note "As a rough rule, the number of fibres of a certain range of lengths is inversely proportional to their length." [4]

The proportion of blood vessels in the white matter in nonelderly adults is 1.7–3.6%. [5]

Grey matter

The other main component of the brain is grey matter (actually pinkish tan due to blood capillaries), which is composed of neurons. The substantia nigra is a third colored component found in the brain that appears darker due to higher levels of melanin in dopaminergic neurons than its nearby areas. Note that white matter can sometimes appear darker than grey matter on a microscope slide because of the type of stain used. Cerebral- and spinal white matter do not contain dendrites, neural cell bodies, or shorter axons,[ citation needed] which can only be found in grey matter.


White matter forms the bulk of the deep parts of the brain and the superficial parts of the spinal cord. Aggregates of grey matter such as the basal ganglia ( caudate nucleus, putamen, globus pallidus, substantia nigra, subthalamic nucleus, nucleus accumbens) and brainstem nuclei ( red nucleus, cranial nerve nuclei) are spread within the cerebral white matter.

The cerebellum is structured in a similar manner as the cerebrum, with a superficial mantle of cerebellar cortex, deep cerebellar white matter (called the " arbor vitae") and aggregates of grey matter surrounded by deep cerebellar white matter ( dentate nucleus, globose nucleus, emboliform nucleus, and fastigial nucleus). The fluid-filled cerebral ventricles (lateral ventricles, third ventricle, cerebral aqueduct, fourth ventricle) are also located deep within the cerebral white matter.

Myelinated axon length

Men have more white matter than women both in volume and in length of myelinated axons. At the age of 20, the total length of myelinated fibers in men is 176,000 km while that of a woman is 149,000 km. [6] There is a decline in total length with age of about 10% each decade such that a man at 80 years of age has 97,200 km and a female 82,000 km. [6] Most of this reduction is due to the loss of thinner fibers. However, this study only included 36 participants. [6]


White matter is the tissue through which messages pass between different areas of grey matter within the central nervous system. The white matter is white because of the fatty substance (myelin) that surrounds the nerve fibers (axons). This myelin is found in almost all long nerve fibers, and acts as an electrical insulation. This is important because it allows the messages to pass quickly from place to place.

Unlike grey matter, which peaks in development in a person's twenties, the white matter continues to develop, and peaks in middle age. [7]


Multiple sclerosis (MS) is the most common of the inflammatory demyelinating diseases of the central nervous system which affect white matter. In MS lesions, the myelin sheath around the axons is deteriorated by inflammation. [8] Alcohol use disorders are associated with a decrease in white matter volume. [9]

Amyloid plaques in white matter may be associated with Alzheimer's disease and other neurodegenerative diseases. [10] Other changes that commonly occur with age include the development of leukoaraiosis, which is a rarefaction of the white matter that can be correlated with a variety of conditions, including loss of myelin pallor, axonal loss, and diminished restrictive function of the blood–brain barrier. [11]

There is also evidence that substance abuse may damage white matter microstucture, though prolonged abstinence may in certain cases may reverse such white matter changes. [12]

White matter lesions on magnetic resonance imaging are linked to several adverse outcomes, such as cognitive impairment and depression. [13] White matter hyperintensity are more than often present with vascular dementia, particularly among small vessel/subcortical subtypes of vascular dementia. [14]


Smaller volumes (in terms of group averages) of white matter might be associated with larger deficits in attention, declarative memory, executive functions, intelligence, and academic achievement. [15] [16] However, volume change is continuous throughout one's lifetime due to neuroplasticity, and is a contributing factor rather than determinant factor of certain functional deficits due to compensating effects in other brain regions. [16] The integrity of white matter declines due to aging. [17] Nonetheless, regular aerobic exercise appears to either postpone the aging effect or in turn enhance the white matter integrity in the long run. [17] Changes in white matter volume due to inflammation or injury may be a factor in the severity of obstructive sleep apnea. [18] [19]


The study of white matter has been advanced with the neuroimaging technique called diffusion tensor imaging where magnetic resonance imaging (MRI) brain scanners are used. As of 2007, more than 700 publications have been published on the subject. [20]

A 2009 paper by Jan Scholz and colleagues [21] used diffusion tensor imaging (DTI) to demonstrate changes in white matter volume as a result of learning a new motor task (e.g. juggling). The study is important as the first paper to correlate motor learning with white matter changes. Previously, many researchers had considered this type of learning to be exclusively mediated by dendrites, which are not present in white matter. The authors suggest that electrical activity in axons may regulate myelination in axons. Or, gross changes in the diameter or packing density of the axon might cause the change. [22][ self-published source?] A more recent DTI study by Sampaio-Baptista and colleagues reported changes in white matter with motor learning along with increases in myelination. [23]

See also


  1. ^ Blumenfeld, Hal (2010). Neuroanatomy through clinical cases (2nd ed.). Sunderland, Mass.: Sinauer Associates. p. 21. ISBN  978-0878936137. Areas of the CNS made up mainly of myelinated axons are called white matter.
  2. ^ Douglas Fields, R. (2008). "White Matter Matters". Scientific American. 298 (3): 54–61. Bibcode: 2008SciAm.298c..54D. doi: 10.1038/scientificamerican0308-54.
  3. ^ Klein, S.B., & Thorne, B.M. Biological Psychology. Worth Publishers: New York. 2007.[ ISBN missing][ page needed]
  4. ^ a b Schüz, Almut; Braitenberg, Valentino (2002). "The human cortical white matter: Quantitative aspects of cortico-cortical long-range connectivity". In Schüz, Almut; Braitenberg, Valentino (eds.). Cortical Areas: Unity and Diversity, Conceptual Advances in Brain Research. Taylor and Francis. pp. 377–386. ISBN  978-0-415-27723-5.
  5. ^ Leenders, K. L.; Perani, D.; Lammertsma, A. A.; Heather, J. D.; Buckingham, P.; Jones, T.; Healy, M. J. R.; Gibbs, J. M.; Wise, R. J. S.; Hatazawa, J.; Herold, S.; Beaney, R. P.; Brooks, D. J.; Spinks, T.; Rhodes, C.; Frackowiak, R. S. J. (1990). "Cerebral Blood Flow, Blood Volume and Oxygen Utilization". Brain. 113: 27–47. doi: 10.1093/brain/113.1.27. PMID  2302536.
  6. ^ a b c Marner, Lisbeth; Nyengaard, Jens R.; Tang, Yong; Pakkenberg, Bente (2003). "Marked loss of myelinated nerve fibers in the human brain with age". The Journal of Comparative Neurology. 462 (2): 144–152. doi: 10.1002/cne.10714. PMID  12794739. S2CID  35293796.
  7. ^ Sowell, Elizabeth R.; Peterson, Bradley S.; Thompson, Paul M.; Welcome, Suzanne E.; Henkenius, Amy L.; Toga, Arthur W. (2003). "Mapping cortical change across the human life span". Nature Neuroscience. 6 (3): 309–315. doi: 10.1038/nn1008. PMID  12548289. S2CID  23799692.
  8. ^ Höftberger, Romana; Lassmann, Hans (2018). "Inflammatory demyelinating diseases of the central nervous system". Handbook of Clinical Neurology. Vol. 145. Elsevier. pp. 263–283. doi: 10.1016/b978-0-12-802395-2.00019-5. ISBN  978-0-12-802395-2. ISSN  0072-9752. PMC  7149979. PMID  28987175.
  9. ^ Monnig, Mollie A.; Tonigan, J. Scott; Yeo, Ronald A.; Thoma, Robert J.; McCrady, Barbara S. (2013). "White matter volume in alcohol use disorders: A meta-analysis". Addiction Biology. 18 (3): 581–592. doi: 10.1111/j.1369-1600.2012.00441.x. PMC  3390447. PMID  22458455.
  10. ^ Roseborough, Austyn; Ramirez, Joel; Black, Sandra E.; Edwards, Jodi D. (2017). "Associations between amyloid β and white matter hyperintensities: A systematic review". Alzheimer's & Dementia. 13 (10): 1154–1167. doi: 10.1016/j.jalz.2017.01.026. ISSN  1552-5260. PMID  28322203. S2CID  35593591.
  11. ^ O'Sullivan, M. (2008-01-01). "Leukoaraiosis". Practical Neurology. 8 (1): 26–38. doi: 10.1136/jnnp.2007.139428. ISSN  1474-7758. PMID  18230707. S2CID  219190542.
  12. ^ Hampton WH, Hanik I, Olson IR (2019). "[Substance Abuse and White Matter: Findings, Limitations, and Future of Diffusion Tensor Imaging Research]". Drug and Alcohol Dependence. 197 (4): 288–298. doi: 10.1016/j.drugalcdep.2019.02.005. PMC  6440853. PMID  30875650. Given that our the central nervous system is an intricately balanced, complex network of billions of neurons and supporting cells, some might imagine that extrinsic substances could cause irreversible brain damage. Our review paints a less gloomy picture of the substances reviewed, however. Following prolonged abstinence, abusers of alcohol (Pfefferbaum et al., 2014) or opiates (Wang et al., 2011) have white matter microstructure that is not significantly different from non-users. There was also no evidence that the white matter microstructural changes observed in longitudinal studies of cannabis, nicotine, or cocaine were completely irreparable. It is therefore possible that, at least to some degree, abstinence can reverse effects of substance abuse on white matter. The ability of white matter to "bounce back" very likely depends on the level and duration of abuse, as well as the substance being abused.
  13. ^ O'Brien, John T. (2014). "Clinical Significance of White Matter Changes". The American Journal of Geriatric Psychiatry. Elsevier BV. 22 (2): 133–137. doi: 10.1016/j.jagp.2013.07.006. ISSN  1064-7481. PMID  24041523.
  14. ^ Hirono, Nobutsugu; Kitagaki, Hajime; Kazui, Hiroaki; Hashimoto, Mamoru; Mori, Etsuro (2000). "Impact of White Matter Changes on Clinical Manifestation of Alzheimer's Disease". Stroke. Ovid Technologies (Wolters Kluwer Health). 31 (9): 2182–2188. doi: 10.1161/01.str.31.9.2182. ISSN  0039-2499. PMID  10978049.
  15. ^ Tasman, Allan (2015). Psychiatry (in Welsh). West Sussex, England: Wiley Blackwell. ISBN  978-1-118-84549-3. OCLC  903956524.
  16. ^ a b Fields, R. Douglas (2008-06-05). "White matter in learning, cognition and psychiatric disorders". Trends in Neurosciences. Elsevier BV. 31 (7): 361–370. doi: 10.1016/j.tins.2008.04.001. ISSN  0166-2236. PMC  2486416. PMID  18538868.
  17. ^ a b Handbook of the Psychology of Aging. Elsevier. 2016. doi: 10.1016/c2012-0-07221-3. ISBN  978-0-12-411469-2.
  18. ^ Castronovo, Vincenza; Scifo, Paola; Castellano, Antonella; Aloia, Mark S.; Iadanza, Antonella; Marelli, Sara; Cappa, Stefano F.; Strambi, Luigi Ferini; Falini, Andrea (2014-09-01). "White Matter Integrity in Obstructive Sleep Apnea before and after Treatment". Sleep. 37 (9): 1465–1475. doi: 10.5665/sleep.3994. ISSN  0161-8105. PMC  4153061. PMID  25142557.
  19. ^ Chen, Hsiu-Ling; Lu, Cheng-Hsien; Lin, Hsin-Ching; Chen, Pei-Chin; Chou, Kun-Hsien; Lin, Wei-Ming; Tsai, Nai-Wen; Su, Yu-Jih; Friedman, Michael; Lin, Ching-Po; Lin, Wei-Che (2015-03-01). "White Matter Damage and Systemic Inflammation in Obstructive Sleep Apnea". Sleep. 38 (3): 361–370. doi: 10.5665/sleep.4490. ISSN  0161-8105. PMC  4335530. PMID  25325459.
  20. ^ Assaf, Yaniv; Pasternak, Ofer (2007). "Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review". Journal of Molecular Neuroscience. 34 (1): 51–61. doi: 10.1007/s12031-007-0029-0. PMID  18157658. S2CID  3354176.
  21. ^ Scholz, Jan; Klein, Miriam C; Behrens, Timothy E J; Johansen-Berg, Heidi (2009). "Training induces changes in white-matter architecture". Nature Neuroscience. 12 (11): 1370–1371. doi: 10.1038/nn.2412. PMC  2770457. PMID  19820707.
  22. ^ "White Matter Matters". Dolan DNA Learning Center. Archived from the original on 2009-11-12. Retrieved 2009-10-19.[ self-published source]
  23. ^ Sampaio-Baptista, C.; Khrapitchev, A. A.; Foxley, S.; Schlagheck, T.; Scholz, J.; Jbabdi, S.; Deluca, G. C.; Miller, K. L.; Taylor, A.; Thomas, N.; Kleim, J.; Sibson, N. R.; Bannerman, D.; Johansen-Berg, H. (2013). "Motor Skill Learning Induces Changes in White Matter Microstructure and Myelination". Journal of Neuroscience. 33 (50): 19499–19503. doi: 10.1523/JNEUROSCI.3048-13.2013. PMC  3858622. PMID  24336716.

Further reading

External links