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A particle beam is a stream of charged or neutral particles. In particle accelerators, these particles can move with a velocity close to the speed of light. There is a difference between the creation and control of charged particle beams and neutral particle beams, as only the first type can be manipulated to a sufficient extent by devices based on electromagnetism. The manipulation and diagnostics of charged particle beams at high kinetic energies using particle accelerators are main topics of accelerator physics.
Charged particles such as electrons, positrons, and protons may be separated from their common surrounding. This can be accomplished by e.g. thermionic emission or arc discharge. The following devices are commonly used as sources for particle beams:
Charged beams may be further accelerated by use of high resonant, sometimes also superconducting, microwave cavities. These devices accelerate particles by interaction with an electromagnetic field. Since the wavelength of hollow macroscopic, conducting devices is in the radio frequency (RF) band, the design of such cavities and other RF devices is also a part of accelerator physics.
More recently, plasma acceleration has emerged as a possibility to accelerate particles in a plasma medium, using the electromagnetic energy of pulsed high-power laser systems or the kinetic energy of other charged particles. This technique is under active development, but cannot provide reliable beams of sufficient quality at present.
Electron beams are employed in synchrotron light sources to produce X-ray radiation with a continuous spectrum over a wide frequency band which is called synchrotron radiation. This X-ray radiation is used at beamlines of the synchrotron light sources for a variety of spectroscopies ( XAS, XANES, EXAFS, µ-XRF, µ-XRD) in order to probe and to characterize the structure and the chemical speciation of solids and biological materials.
Many phenomena in astrophysics are attributed to particle beams of various kinds.  Solar Type III radio bursts, the most common impulsive radio signatures from the Sun, are used by scientists as a tool to better understand solar accelerated electron beams. 
The U.S. Advanced Research Projects Agency started work on particle beam weapons in 1958.  The general idea of such weaponry is to hit a target object with a stream of accelerated particles with high kinetic energy, which is then transferred to the atoms, or molecules, of the target. The power needed to project a high-powered beam of this kind surpasses the production capabilities of any standard battlefield powerplant,  thus such weapons are not anticipated to be produced in the foreseeable future.