Karl Barry Sharpless Information (Person)

From Wikipedia

Barry Sharpless
Barry Sharpless 02.jpg
Sharpless in 2018
Karl Barry Sharpless

(1941-04-28) April 28, 1941 (age 81)
Philadelphia, Pennsylvania, U.S.
Alma mater Dartmouth College ( BA)
Stanford University ( MS, PhD)
Known for
Jan Dueser
( m. 1965)
Scientific career
Fields Chemistry
Thesis Studies of the Mechanism of Action of 2,3-oxidosqualene-lanosterol cyclase: Featuring Enzymic Cyclization of Modified Squalene Oxides (1968)
Doctoral advisor Eugene van Tamelen
Doctoral students M.G. Finn
Other notable students Hartmuth Kolb

Karl Barry Sharpless (born April 28, 1941) is an American chemist and a two-time Nobel laureate in Chemistry known for his work on stereoselective reactions and click chemistry.

Sharpless was awarded half of the 2001 Nobel Prize in Chemistry "for his work on chirally catalysed oxidation reactions", and one third of the 2022 prize, jointly with Carolyn R. Bertozzi and Morten P. Meldal, "for the development of click chemistry and bioorthogonal chemistry". [1] [2] Sharpless is the only living person awarded with two Nobel prizes, as only five persons (in addition to two organizations), have been awarded with two Nobel prizes, including John Bardeen, Frederick Sanger, Marie Curie and Linus Pauling.

Early life and education

Sharpless was born April 28, 1941, in Philadelphia, Pennsylvania. [3] His childhood was filled with summers at his family cottage on the Manasquan River in New Jersey. This is where Sharpless developed a love for fishing that he would continue throughout his life, spending summers in college working on fishing boats. [4] He graduated from Friends' Central School in 1959, [5] and continued his studies at Dartmouth College, earning an A.B. in 1963. Sharpless originally planned to attend medical school after his undergraduate degree, but his research professor convinced him to continue his education in chemistry. [6] He earned his Ph.D. in Organic Chemistry from Stanford University in 1968 under Eugene van Tamelen. [7] He continued post-doctoral work at Stanford University (1968–1969) with James P. Collman, working on organometallic chemistry. Sharpless then moved to Harvard University (1969–1970), studying enzymology in Konrad E. Bloch's lab. [6]

Academic career

Sharpless was a professor at the Massachusetts Institute of Technology (1970–1977, 1980–1990) and Stanford University (1977–1980). [8] While at Stanford, Sharpless discovered Sharpless asymmetric epoxidation, which was used to make (+)-disparlure.


Sharpless developed stereoselective oxidation reactions, and showed that the formation of an inhibitor with femtomolar potency can be catalyzed by the enzyme acetylcholinesterase, beginning with an azide and an alkyne. He discovered several chemical reactions which have transformed asymmetric synthesis from science fiction to the relatively routine, including aminohydroxylation, dihydroxylation, and the Sharpless asymmetric epoxidation. [9]

In 2001 he was awarded a half-share of the Nobel Prize in Chemistry for his work on chirally catalyzed oxidation reactions ( Sharpless epoxidation, Sharpless asymmetric dihydroxylation, Sharpless oxyamination). The other half of the year's Prize was shared between William S. Knowles and Ryōji Noyori (for their work on stereoselective hydrogenation). [10]

The term " click chemistry" was coined by Sharpless in 1998, and was first fully described by Sharpless, Hartmuth Kolb, and M.G. Finn at The Scripps Research Institute in 2001. [11] [12] This involves a set of highly selective, exothermic reactions which occur under mild conditions; the most successful example is the azide alkyne Huisgen cycloaddition to form 1,2,3-triazoles. [13]

As of 2022, Sharpless has an h-index of 180 according to Google Scholar [14] and of 124 according to Scopus. [15]

Awards and honors

Sharpless is a two-time Nobel Laureate. He is a recipient of the 2001 and 2022 Nobel Prize in Chemistry for his work on "chirally catalysed oxidation reactions", and "click chemistry", respectively. [2] [16]

In 2019, Sharpless was awarded the Priestley medal, the American Chemical Society's highest honor, for "the invention of catalytic, asymmetric oxidation methods, the concept of click chemistry and development of the copper-catalyzed version of the azide-acetylene cycloaddition reaction.". [5] [6]

He is Distinguished University Professor at Kyushu University. He holds honorary degrees from the KTH Royal Institute of Technology (1995), Technical University of Munich (1995), Catholic University of Louvain (1996) and Wesleyan University (1999). [8]

Personal life

Sharpless married Jan Dueser in 1965 and they have three children. [9] He was blinded in one eye during a lab accident in 1970 where an NMR tube exploded, shortly after he arrived at MIT as an assistant professor. After this accident, Sharpless stresses "there's simply never an adequate excuse for not wearing safety glasses in the laboratory at all times." [17]


  1. ^ "The Nobel Prize in Chemistry 2001". Nobel Foundation. Retrieved October 5, 2022.
  2. ^ a b "The Nobel Prize in Chemistry 2022". Nobel Foundation. Retrieved October 5, 2022.
  3. ^ "K. Barry Sharpless | Biography, Nobel Prize, & Facts | Britannica". britannica.com. Retrieved October 14, 2022.
  4. ^ Sharpless, Barry (December 8, 2001). "Searching For New Reactivity" (PDF). Nobel Prize.{{ cite web}}: CS1 maint: url-status ( link)
  5. ^ a b "2019 Priestley Medalist K. Barry Sharpless works magic in the world of molecules". Chemical & Engineering News. Retrieved April 8, 2019.
  6. ^ a b c "K. Barry Sharpless named 2019 Priestley Medalist". Chemical & Engineering News. Retrieved April 8, 2019.
  7. ^ Sharpless, Karl Barry (1968). Studies of the mechanism of action of 2,3-oxidosqualene-lanosterol cyclase: featuring enzymic cyclization of modified squalene oxides (Ph.D.). Stanford University. OCLC  66229398 – via ProQuest.
  8. ^ a b Henderson, Andrea Kovacs (2009). American Men & Women of Science. Farmington Hills, MI: Gale. Cengage Learning. pp.  764. ISBN  9781414433066.
  9. ^ a b "K. Barry Sharpless". Notable Names Database. Soylent Communications. 2014. Retrieved July 12, 2014.
  10. ^ "The Nobel Prize in Chemistry 2001". Nobelprize.org. The Nobel Foundation. 2001. Retrieved July 12, 2014.
  11. ^ Kolb, Hartmuth C.; Finn, M. G.; Sharpless, K. Barry (June 1, 2001). "Click Chemistry: Diverse Chemical Function from a Few Good Reactions". Angewandte Chemie. 40 (11): 2004–2021. doi: 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5. ISSN  1521-3773. PMID  11433435.
  12. ^ "ScienceWatch.com - Clarivate". archive.sciencewatch.com. Retrieved October 5, 2022.
  13. ^ Evans, Richard A. (2007). "The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification". Australian Journal of Chemistry. 60 (6): 384. doi: 10.1071/CH06457. ISSN  0004-9425.
  14. ^ Karl Barry Sharpless publications indexed by Google Scholar Edit this at Wikidata[ dead link]
  15. ^ "Scopus preview – Sharpless, K. Barry – Author details – Scopus". www.scopus.com. Retrieved October 16, 2021.
  16. ^ "The Nobel Prize in Chemistry 2001". NobelPrize.org. Retrieved April 5, 2019.
  17. ^ "A cautionary tale from the past". MIT News | Massachusetts Institute of Technology. Retrieved October 5, 2022.

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