The radial velocity of an object with respect to a given point is the rate of change of the distance between the object and the point. That is, the radial velocity is the component of the object's velocity that points in the direction of the radius connecting the point and the object. In astronomy, the point is usually taken to be the observer on Earth, so the radial velocity then denotes the speed with which the object moves away from the Earth (or approaches it, for a negative radial velocity).
In astronomy, radial velocity is often measured to the first order of approximation by Doppler spectroscopy. The quantity obtained by this method may be called the barycentric radial-velocity measure or spectroscopic radial velocity.  However, due to relativistic and cosmological effects over the great distances that light typically travels to reach the observer from an astronomical object, this measure cannot be accurately transformed to a geometric radial velocity without additional assumptions about the object and the space between it and the observer.  By contrast, astrometric radial velocity is determined by astrometric observations (for example, a secular change in the annual parallax).   
Light from an object with a substantial relative radial velocity at emission will be subject to the Doppler effect, so the frequency of the light decreases for objects that were receding ( redshift) and increases for objects that were approaching ( blueshift).
The radial velocity of a star or other luminous distant objects can be measured accurately by taking a high-resolution spectrum and comparing the measured wavelengths of known spectral lines to wavelengths from laboratory measurements. A positive radial velocity indicates the distance between the objects is or was increasing; a negative radial velocity indicates the distance between the source and observer is or was decreasing.
In many binary stars, the orbital motion usually causes radial velocity variations of several kilometres per second (km/s). As the spectra of these stars vary due to the Doppler effect, they are called spectroscopic binaries. Radial velocity can be used to estimate the ratio of the masses of the stars, and some orbital elements, such as eccentricity and semimajor axis. The same method has also been used to detect planets around stars, in the way that the movement's measurement determines the planet's orbital period, while the resulting radial-velocity amplitude allows the calculation of the lower bound on a planet's mass using the binary mass function. Radial velocity methods alone may only reveal a lower bound, since a large planet orbiting at a very high angle to the line of sight will perturb its star radially as much as a much smaller planet with an orbital plane on the line of sight. It has been suggested that planets with high eccentricities calculated by this method may in fact be two-planet systems of circular or near-circular resonant orbit.  
The radial velocity method to detect exoplanets is based on the detection of variations in the velocity of the central star, due to the changing direction of the gravitational pull from an (unseen) exoplanet as it orbits the star. When the star moves towards us, its spectrum is blueshifted, while it is redshifted when it moves away from us. By regularly looking at the spectrum of a star—and so, measuring its velocity—it can be determined if it moves periodically due to the influence of an exoplanet companion.
From the instrumental perspective, velocities are measured relative to the telescope's motion. So an important first step of the data reduction is to remove the contributions of
- the Earth's elliptic motion around the sun at approximately ± 30 km/s,
- a monthly rotation of ± 13 m/s of the Earth around the center of gravity of the Earth-Moon system, 
- the daily rotation of the telescope with the Earth crust around the Earth axis, which is up to ±460 m/s at the equator and proportional to the cosine of the telescope's geographic latitude,
- small contributions from the Earth polar motion at the level of mm/s,
- contributions of 230 km/s from the motion around the Galactic center and associated proper motions. 
- in the case of spectroscopic measurements corrections of the order of ±20 cm/s with respect to aberration. 
- Sin i degeneracy is the impact caused by not being in the plane of the motion.
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