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Human spaceflight (also referred to as manned spaceflight or crewed spaceflight) is spaceflight with a crew or passengers aboard a spacecraft, the spacecraft being operated directly by the onboard human crew. Spacecraft can also be remotely operated from ground stations on Earth, or autonomously, without any direct human involvement. People trained for spaceflight are called astronauts, cosmonauts, or taikonauts; and non-professionals are referred to as spaceflight participants.
The first human in space was Yuri Gagarin, who flew the Vostok 1 spacecraft, which was launched by the Soviet Union on 12 April 1961 as part of the Vostok program. Humans traveled to the Moon nine times between 1968 and 1972 as part of the United States Apollo program, and have had a continuous presence in space for 20 years and 197 days on the International Space Station (ISS). 
To date, Russia, the United States, and China are the only countries with public or commercial human spaceflight-capable programs. Non-governmental spaceflight companies have been working to develop human space programs of their own, e.g. for space tourism or commercial in-space research. The first private human spaceflight launch was a suborbital flight on SpaceShipOne on June 21, 2004. The first commercial orbital crew launch was by SpaceX in May 2020, transporting, under government contract, astronauts to the ISS. 
Human spaceflight capability was first developed during the Cold War between the United States and the Soviet Union (USSR). These nations developed intercontinental ballistic missiles for the delivery of nuclear weapons, producing rockets large enough to be adapted to carry the first artificial satellites into low Earth orbit.
After the first satellites were launched in 1957 and 1958 by the Soviet Union, the US began work on Project Mercury, with the aim of launching men into orbit. The USSR was secretly pursuing the Vostok program to accomplish the same thing, and launched the first human into space, the cosmonaut Yuri Gagarin, who, on 12 April 1961, was launched aboard Vostok 1 on a Vostok 3KA rocket and completed a single orbit. On 5 May 1961, the US launched its first astronaut, Alan Shepard, on a suborbital flight aboard Freedom 7 on a Mercury-Redstone rocket. Unlike Gagarin, Shepard manually controlled his spacecraft's attitude. On 20 February 1962, John Glenn became the first American in orbit, aboard Friendship 7 on a Mercury-Atlas rocket. The USSR launched five more cosmonauts in Vostok capsules, including the first woman in space, Valentina Tereshkova aboard Vostok 6, on 16 June 1963. Through 1963, the US launched a total of two astronauts in suborbital flights and four into orbit. The US also made two North American X-15 flights ( 90 and 91, piloted by Joseph A. Walker) that exceeded the Kármán line, the 100 kilometres (62 mi) altitude used by the Fédération Aéronautique Internationale (FAI) to denote the edge of space.
In 1961, US President John F. Kennedy raised the stakes of the Space Race by setting the goal of landing a man on the Moon and returning him safely to Earth by the end of the 1960s.  That same year, the US began the Apollo program of launching three-man capsules atop the Saturn family of launch vehicles to accomplish this; and, in 1962, began Project Gemini, which, in 1965 and 1966, flew 10 missions with two-man crews launched by Titan II rockets, Gemini's objective being to support Apollo by developing American orbital spaceflight experience and techniques to be used during the Moon mission. 
Meanwhile, the USSR remained silent about their intentions to send humans to the Moon, and proceeded to stretch the limits of their single-pilot Vostok capsule by adapting it to a two or three-person Voskhod capsule to compete with Gemini. They were able to launch two orbital flights in 1964 and 1965 and achieved the first spacewalk, performed by Alexei Leonov on Voskhod 2 on 8 March 1965. However, the Voskhod did not have Gemini's capability to maneuver in orbit, and the program was terminated. The US Gemini flights did not achieve the first spacewalk, but overcame the early Soviet lead by performing several spacewalks, solving the problem of astronaut fatigue caused by compensating for the lack of gravity, demonstrating the ability of humans to endure two weeks in space, and performing the first space rendezvous and docking of spacecraft.
The US succeeded in developing the Saturn V rocket necessary to send the Apollo spacecraft to the Moon, and sent Frank Borman, James Lovell, and William Anders into 10 orbits around the Moon in Apollo 8 in December 1968. In July 1969, Apollo 11 accomplished Kennedy's goal by landing Neil Armstrong and Buzz Aldrin on the Moon on 21 July and returning them safely on 24 July, along with Command Module pilot Michael Collins. Through 1972, a total of six Apollo missions landed 12 men to walk on the Moon, half of which drove electric powered vehicles on the surface. The crew of Apollo 13— Jim Lovell, Jack Swigert, and Fred Haise—survived a catastrophic in-flight spacecraft failure, orbited the Moon without landing, and returned safely to Earth.
Meanwhile, the USSR secretly pursued crewed lunar orbiting and landing programs. They successfully developed the three-person Soyuz spacecraft for use in the lunar programs, but failed to develop the N1 rocket necessary for a human landing, discontinuing their lunar programs in 1974.  Upon losing the Moon race they concentrated on the development of space stations, using the Soyuz as a ferry to take cosmonauts to and from the stations. They started with a series of Salyut sortie stations from 1971 to 1986.
In 1969, Nixon appointed his vice president, Spiro Agnew, to head a Space Task Group to recommend follow-on human spaceflight programs after Apollo. The group proposed an ambitious Space Transportation System based on a reusable Space Shuttle, which consisted of a winged, internally fueled orbiter stage burning liquid hydrogen, launched with a similar, but larger kerosene-fueled booster stage, each equipped with airbreathing jet engines for powered return to a runway at the Kennedy Space Center launch site. Other components of the system included a permanent, modular space station; reusable space tug; and nuclear interplanetary ferry, leading to a human expedition to Mars as early as 1986 or as late as 2000, depending on the level of funding allocated. However, Nixon knew the American political climate would not support congressional funding for such an ambition, and killed proposals for all but the Shuttle, possibly to be followed by the space station. Plans for the Shuttle were scaled back to reduce development risk, cost, and time, replacing the piloted fly back booster with two reusable solid rocket boosters, and the smaller orbiter would use an expendable external propellant tank to feed its hydrogen-fueled main engines. The orbiter would have to make unpowered landings.
In 1973, the US launched the Skylab sortie space station and inhabited it for 171 days with three crews ferried aboard Apollo spacecraft. During that time, President Richard Nixon and Soviet general secretary Leonid Brezhnev were negotiating an easing of Cold War tensions known as détente. As part of this, they negotiated the Apollo-Soyuz program, in which an Apollo spacecraft carrying a special docking adapter module rendezvoused and docked with Soyuz 19 in 1975. The American and Russian crews shook hands in space, but the purpose of the flight was purely symbolic.
The two nations continued to compete rather than cooperate in space, as the US turned to developing the Space Shuttle and planning the space station, which was dubbed Freedom. The USSR launched three Almaz military sortie stations from 1973 to 1977, disguised as Salyuts. They followed Salyut with the development of Mir, the first modular, semi-permanent space station, the construction of which took place from 1986 to 1996. Mir orbited at an altitude of 354 kilometers (191 nautical miles), at an orbital inclination of 51.6°. It was occupied for 4,592 days and made a controlled reentry in 2001.
The Space Shuttle started flying in 1981, but the US Congress failed to approve sufficient funds to make Space Station Freedom a reality. A fleet of four shuttles was built: Columbia, Challenger, Discovery, and Atlantis. A fifth shuttle, Endeavour, was built to replace Challenger, which was destroyed in an accident during launch that killed 7 astronauts on 28 January 1986. From 1983 to 1998, twenty-two Shuttle flights carried components for a European Space Agency sortie space station called Spacelab in the Shuttle payload bay. 
The USSR copied the US's reusable Space Shuttle orbiter, which they called Buran-class orbiter or simply Buran, which was designed to be launched into orbit by the expendable Energia rocket, and capable of robotic orbital flight and landing. Unlike the Space Shuttle, Buran had no main rocket engines, but like the Space Shuttle orbiter it used smaller rocket engines to perform its final orbital insertion. A single uncrewed orbital test flight took place in November 1988. A second test flight was planned by 1993, but the program was canceled due to lack of funding and the dissolution of the Soviet Union in 1991. Two more orbiters were never completed, and the one that performed the uncrewed flight was destroyed in a hangar roof collapse in May 2002.
The dissolution of the Soviet Union in 1991 brought an end to the Cold War and opened the door to true cooperation between the US and Russia. The Soviet Soyuz and Mir programs were taken over by the Russian Federal Space Agency, now known as the Roscosmos State Corporation. The Shuttle-Mir Program included American Space Shuttles visiting the Mir space station, Russian cosmonauts flying on the Shuttle, and an American astronaut flying aboard a Soyuz spacecraft for long-duration expeditions aboard Mir.
In 1993, President Bill Clinton secured Russia's cooperation in converting the planned Space Station Freedom into the International Space Station (ISS). Construction of the station began in 1998. The station orbits at an altitude of 409 kilometers (221 nmi) and an orbital inclination of 51.65°. Several of the Space Shuttle's 135 orbital flights were to help assemble, supply, and crew the ISS. Russia has built half of the International Space Station and has continued its cooperation with the US.
After Russia's launch of Sputnik 1 in 1957, Chairman Mao Zedong intended to place a Chinese satellite in orbit by 1959 to celebrate the 10th anniversary of the founding of the People's Republic of China (PRC).  However, China did not successfully launch its first satellite until 24 April 1970. On 14 July 1967, Mao and Premier Zhou Enlai decided that the PRC should not be left behind, and started China's own human spaceflight program.  However, the first attempt, the Shuguang spacecraft, which was copied from the US Gemini craft, was canceled on 13 May 1972.
China later designed the Shenzhou spacecraft, which resembled the Russian Soyuz, and became the third nation to achieve independent human spaceflight capability by launching Yang Liwei on a 21-hour flight aboard Shenzhou 5 on 15 October 2003. China launched the Tiangong-1 space station on 29 September 2011, and two sortie missions to it: Shenzhou 9 16–29 June 2012, with China's first female astronaut Liu Yang; and Shenzhou 10, 13–26 June 2013. The station was retired on 21 March 2016 and reentered Earth's atmosphere on 2 April 2018, burning up with small fragments impacting the Pacific Ocean. Tiangong-1's successor Tiangong-2 was launched in September 2016. Tiangong-2 hosted a crew of two— Jing Haipeng and Chen Dong—for 30 days. On 22 April 2017, the Tianzhou 1 cargo spacecraft docked with the station, which was later deorbited, in July 2019, burning up over the Pacific.
The European Space Agency began development of the Hermes shuttle spaceplane in 1987, to be launched on the Ariane 5 expendable launch vehicle. It was intended to dock with the European Columbus space station. The projects were canceled in 1992, when it became clear that neither cost nor performance goals could be achieved. No Hermes shuttles were ever built. The Columbus space station was reconfigured as the European module of the same name on the International Space Station.[ citation needed]
Japan ( NASDA) began development of the HOPE-X experimental shuttle spaceplane in the 1980s, to be launched on its H-IIA expendable launch vehicle. A string of failures in 1998 led to funding reductions, and the project's cancellation in 2003 in favor of participation in the International Space Station program through the Kibō Japanese Experiment Module and H-II Transfer Vehicle cargo spacecraft. As an alternative to HOPE-X, NASDA in 2001 proposed the Fuji crew capsule for independent or ISS flights, but the project did not proceed to the contracting stage.[ citation needed]
From 1993 to 1997, the Japanese Rocket Society [ ja], Kawasaki Heavy Industries, and Mitsubishi Heavy Industries worked on the proposed Kankoh-maru vertical-takeoff-and-landing single-stage-to-orbit reusable launch system. In 2005, this system was proposed for space tourism.[ citation needed]
According to a press release from the Iraqi News Agency dated 5 December 1989, there was only one test of the Al-Abid space launcher, which Iraq intended to use to develop its own crewed space facilities by the end of the century. These plans were put to an end by the Gulf War of 1991 and the economic hardships that followed.[ citation needed]
Under the Bush administration, the Constellation program included plans for retiring the Space Shuttle program and replacing it with the capability for spaceflight beyond low Earth orbit. In the 2011 United States federal budget, the Obama administration canceled Constellation for being over budget and behind schedule while not innovating and investing in critical new technologies.  As part of the Artemis program, NASA is developing the Orion spacecraft to be launched by the Space Launch System. Under the Commercial Crew Development plan, NASA relies on transportation services provided by the private sector to reach low Earth orbit, such as SpaceX Dragon 2, the Boeing Starliner or Sierra Nevada Corporation's Dream Chaser. The period between the retirement of the Space Shuttle in 2011 and the first launch into space of SpaceShipTwo Flight VP-03 on 13 December 2018 is similar to the gap between the end of Apollo in 1975 and the first Space Shuttle flight in 1981, and is referred to by a presidential Blue Ribbon Committee as the U.S. human spaceflight gap.
Since the early 2000s, a variety of private spaceflight ventures have been undertaken. As of May 2021, SpaceX has launched humans to orbit, while Virgin Galactic has launched crew to a height above 80 km (50 mi) on a suborbital trajectory.  Several other companies—including Blue Origin and Sierra Nevada—develop crewed spacecraft. All four companies plan to fly commercial passengers in the emerging space tourism market.
SpaceX has developed Crew Dragon flying on Falcon 9. It first launched astronauts to orbit and to the ISS in May 2020 as part of the Demo-2 mission. Developed as part of NASA's Commercial Crew Development program, the capsule is also available for flights with other customers. A first tourist mission, Inspiration4, is planned for September 2021.
Boeing is developing the Starliner capsule as part of NASA's Commercial Crew Development program, which is launched on a United Launch Alliance Atlas V launch vehicle.  As of May 2021, Starliner has made one uncrewed flight. A crewed flight is planned for late 2021. Similar to SpaceX, development funding has been provided by a mix of government and private funds.  
Over the decades, a number of spacecraft have been proposed for spaceliner passenger travel. Somewhat analogous to travel by airliner after the middle of the 20th century, these vehicles are proposed to transport large numbers of passengers to destinations in space, or on Earth via suborbital spaceflights. To date, none of these concepts have been built, although a few vehicles that carry fewer than 10 persons are currently in the test flight phase of their development process.
One large spaceliner concept currently in early development is the SpaceX Starship, which, in addition to replacing the Falcon 9 and Falcon Heavy launch vehicles in the legacy Earth-orbit market after 2020, has been proposed by SpaceX for long-distance commercial travel on Earth, flying 100+ people suborbitally between two points in under one hour, also known as "Earth-to-Earth".   
Small spaceplane or small capsule suborbital spacecraft have been under development for the past decade or so; as of 2017 [update], at least one of each type is under development. Both Virgin Galactic and Blue Origin have craft in active development: the SpaceShipTwo spaceplane and the New Shepard capsule, respectively. Both would carry approximately a half-dozen passengers up to space for a brief time of zero gravity before returning to the launch location. XCOR Aerospace had been developing the Lynx single-passenger spaceplane since the 2000s,   but development was halted in 2017. 
Participation and representation of humanity in space has been an issue ever since the first phase of space exploration.  Some rights of non-spacefaring countries have been secured through international space law, declaring space the " province of all mankind", though the sharing of space by all humanity is sometimes criticized as imperialist and lacking.  In addition to the lack of international inclusion, the inclusion of women and people of color has also been lacking. To make spaceflight more inclusive, organizations such as the Justspace Alliance  and IAU-featured Inclusive Astronomy  have been formed in recent years.
The first woman to ever enter space was Valentina Tereshkova. She flew in 1963, but it was not until the 1980s that another woman entered space again. At the time, all astronauts were required to be military test pilots; and women were not able to enter this career, which is one reason for the delay in allowing women to join space crews.[ citation needed] After the rules were changed, Svetlana Savitskaya became the second woman to enter space; she was also from the Soviet Union. Sally Ride became the next woman to enter space and the first woman to enter space through the United States program.
Since then, eleven other countries have allowed women astronauts. The first all-female space walk occurred in 2018, by Christina Koch and Jessica Meir. These two women had both participated in separate space walks with NASA. The first woman to go to the moon is planned for 2024.
Despite these developments women are still underrepresented among astronauts and especially cosmonauts. Issues that block potential applicants from the programs, and limit the space missions they are able to go on, are, for example:
- agencies limiting women to half as much time in space than men, due to suppositions that women are at greater potential risk for cancer. 
- a lack of space suits sized appropriately for female astronauts. 
- 12 April 1961
- Yuri Gagarin was the first human in space and the first in Earth orbit, on Vostok 1.
- 17 July 1962 or 19 July 1963
- Either Robert M. White or Joseph A. Walker (depending on the definition of the space border) was the first to pilot a spaceplane, the North American X-15, on 17 July 1962 (White) or 19 July 1963 (Walker).
- 18 March 1965
- Alexei Leonov was first to walk in space.
- 15 December 1965
- Walter M. Schirra and Tom Stafford were first to perform a space rendezvous, piloting their Gemini 6A spacecraft to achieve station-keeping one foot (30 cm) from Gemini 7 for over 5 hours.
- 16 March 1966
- Neil Armstrong and David Scott were first to rendezvous and dock, piloting their Gemini 8 spacecraft to dock with an uncrewed Agena Target Vehicle.
- 21–27 December 1968
- Frank Borman, Jim Lovell, and William Anders were first to travel beyond low Earth orbit (LEO) and first to orbit the Moon, on the Apollo 8 mission, which orbited the Moon ten times before returning to Earth.
- 20 July 1969
- Neil Armstrong and Buzz Aldrin were first to land on the Moon, during Apollo 11.
- Longest time in space
- Valeri Polyakov performed the longest single spaceflight, from 8 January 1994 to 22 March 1995 (437 days, 17 hours, 58 minutes, and 16 seconds). Gennady Padalka has spent the most total time in space on multiple missions, 879 days.
- Longest-duration crewed space station
- The International Space Station has the longest period of continuous human presence in space, 2 November 2000 to present (20 years and 197 days). This record was previously held by Mir, from Soyuz TM-8 on 5 September 1989 to the Soyuz TM-29 on 28 August 1999, a span of 3,644 days (almost 10 years).
- 12 April 1961
- Yuri Gagarin became the first Soviet and the first human to reach space, on Vostok 1.
- 5 May 1961
- Alan Shepard became the first American to reach space, on Freedom 7.
- 20 February 1962
- John Glenn became the first American to orbit the Earth.
- 16 June 1963
- Valentina Tereshkova became the first woman to go into space and to orbit the Earth.
- 2 March 1978
- Vladimír Remek, a Czechoslovakian, became the first non-American and non-Soviet in space, as part of the Interkosmos program.
- 2 April 1984
- Rakesh Sharma, became the first Indian citizen to reach Earth's orbit.
- 25 July 1984
- Svetlana Savitskaya became the first woman to walk in space.
- 15 October 2003
- Yang Liwei became the first Chinese in space and to orbit the Earth, on Shenzhou 5.
- 18 October 2019
- Christina Koch and Jessica Meir conducted the first woman-only walk in space. 
Sally Ride became the first American woman in space, in 1983. Eileen Collins was the first female Shuttle pilot, and with Shuttle mission STS-93 in 1999 she became the first woman to command a U.S. spacecraft.
For many years, only the USSR (later Russia) and the United States were the only countries whose astronauts flew in space. That ended with the 1978 flight of Vladimir Remek. As of 2010 [update], citizens from 38 nations (including space tourists) have flown in space aboard Soviet, American, Russian, and Chinese spacecraft.
The following space vehicles and spaceports are currently used for launching human spaceflights:
- Soyuz program ( USSR/Russia): spacecraft on Soyuz launch vehicle, from Baikonur Cosmodrome; 140 crewed orbital flights since 1967, including two in-flight aborts which failed to reach orbit, as of March 2019 [update]
- Shenzhou program (China): spacecraft on Long March launch vehicle, from Jiuquan Satellite Launch Center; 6 flights since 2003, as of May 2021 [update]
- SpaceShipTwo (US): Air launched from White Knight Two carrier aircraft. 2 suborbital spaceflights since 2018, as of February 2019
- Crew Dragon (US): Part of the Commercial Crew Program, launched from Kennedy Space Center on a Falcon 9 rocket. Two successful launches with more in the planning stages. 
The following space stations are currently maintained in Earth orbit for human occupation:
- International Space Station (US, ESA, JAXA, CSA and Russia) assembled in orbit: altitude 409 kilometers (221 nautical miles), 51.65° orbital inclination; crews transported by Soyuz or Crew Dragon spacecraft
Most of the time, the only humans in space are those aboard the ISS, whose crew of up to 7 spends up to six months at a time in low Earth orbit.
Numerous private companies attempted human spaceflight programs in an effort to win the $10 million Ansari X Prize. The first private human spaceflight took place on 21 June 2004, when SpaceShipOne conducted a suborbital flight. SpaceShipOne captured the prize on 4 October 2004, when it accomplished two consecutive flights within one week.
NASA and ESA use the term "human spaceflight" to refer to their programs of launching people into space. These endeavors have also been referred to as "manned space missions", though because of gender specificity this is no longer official parlance according to NASA style guides. 
Under the Indian Human Spaceflight Program, India is planning to send humans into space on its orbital vehicle Gaganyaan before August 2022. The Indian Space Research Organisation (ISRO) began work on this project in 2006.   The initial objective is to carry a crew of two or three to low Earth orbit (LEO) for a 3-to-7-day flight in a spacecraft on a GSLV Mk III rocket and return them safely for a water landing at a predefined landing zone. On 15 August 2018, Indian Prime Minister Narendra Modi, declared India will independently send humans into space before the 75th anniversary of independence in 2022.  In 2019, ISRO revealed plans for a space station by 2030, followed by a crewed lunar mission. The program envisages the development of a fully-autonomous orbital vehicle capable of carrying 2 or 3 crew members to an about 300 km (190 mi) low Earth orbit and bringing them safely back home. 
NASA is developing a plan to land humans on Mars by the 2030s. The first step will begin with Artemis 1 in 2021, sending an uncrewed Orion spacecraft to a distant retrograde orbit around the Moon and returning it to Earth after a 25-day mission.
Several other countries and space agencies have announced and begun human spaceflight programs using natively developed equipment and technology, including Japan ( JAXA), Iran ( ISA), and North Korea ( NADA). The plans for the Iranian crewed spacecraft are for a small spacecraft and space laboratory. North Korea's space program has plans for crewed spacecraft and small shuttle systems.
- This section lists all nations which have attempted human spaceflight programs. This should not to be confused with nations with citizens who have traveled into space, including space tourists, flown or intending to fly by a foreign country's or non-domestic private company's space systems – who are not counted in this list toward their country's national spacefaring attempts.
There are two main sources of hazard in space flight: those due to the hostile space environment, and those due to possible equipment malfunctions. Addressing these issues is of great important for NASA and other space agencies before conducting the first extended crewed missions to destinations such as Mars. 
Planners of human spaceflight missions face a number of safety concerns.
The basic needs for breathable air and drinkable water are addressed by the life support system of the spacecraft.
Astronauts may not be able to quickly return to Earth or receive medical supplies, equipment, or personnel if a medical emergency occurs. The astronauts may have to rely for long periods on limited resources and medical advice from the ground.
On 2 November 2017, scientists reported, based on MRI studies, that significant changes in the position and structure of the brain have been found in astronauts who have taken trips in space. Astronauts on longer space trips were affected by greater brain changes.  
Researchers in 2018 reported, after detecting the presence on the International Space Station (ISS) of five Enterobacter bugandensis bacterial strains, none pathogenic to humans, that microorganisms on ISS should be carefully monitored to assure a healthy environment for astronauts.  
Medical data from astronauts in low Earth orbits for long periods, dating back to the 1970s, show several adverse effects of a microgravity environment: loss of bone density, decreased muscle strength and endurance, postural instability, and reductions in aerobic capacity. Over time these deconditioning effects can impair astronauts' performance or increase their risk of injury. 
In a weightless environment, astronauts put almost no weight on the back muscles or leg muscles used for standing up, which causes the muscles to weaken and get smaller. Astronauts can lose up to twenty per cent of their muscle mass on spaceflights lasting five to eleven days. The consequent loss of strength could be a serious problem in case of a landing emergency.  Upon returning to Earth from long-duration flights, astronauts are considerably weakened and are not allowed[ by whom?] to drive a car for twenty-one days. 
Astronauts experiencing weightlessness will often lose their orientation, get motion sickness, and lose their sense of direction as their bodies try to get used to a weightless environment. When they get back to Earth, they have to readjust and may have problems standing up, focusing their gaze, walking, and turning. Importantly, those motor disturbances only get worse the longer the exposure to weightlessness.  These changes can affect the ability to perform tasks required for approach and landing, docking, remote manipulation, and emergencies that may occur while landing. 
In addition, after long space flight missions, male astronauts may experience severe eyesight problems, which may be a major concern for future deep space flight missions, including a crewed mission to the planet Mars.       Long space flights can also alter a space traveler's eye movements. 
Without proper shielding, the crews of missions beyond low Earth orbit might be at risk from high-energy protons emitted by solar flares and associated solar particle events (SPEs). Lawrence Townsend of the University of Tennessee and others have studied the overall most powerful solar storm ever recorded. The flare was seen by the British astronomer Richard Carrington in September 1859. Radiation doses astronauts would receive from a Carrington-type storm could cause acute radiation sickness and possibly even death.  Another storm that could have inflicted a lethal radiation dose on astronauts outside Earth's protective magnetosphere occurred during the Space Age, shortly after Apollo 16 landed and before Apollo 17 launched.  This solar storm of August 1972 would likely have caused acute illness, at least. 
There is also some scientific concern that extended spaceflight might slow down the body's ability to protect itself against diseases,  resulting in a weakened immune system and the activation of dormant viruses in the body. Radiation can cause both short- and long-term consequences to the bone marrow stem cells from which blood and immune-system cells are created. Because the interior of a spacecraft is so small, a weakened immune system and more active viruses in the body can lead to a fast spread of infection.[ citation needed]
During long missions, astronauts are isolated and confined in small spaces. Depression, anxiety, cabin fever, and other psychological problems may occur more than for an average person and could impact the crew's safety and mission success.  NASA spends millions of dollars on psychological treatments for astronauts and former astronauts.  To date, there is no way to prevent or reduce mental problems caused by extended periods of stay in space.
Due to these mental disorders, the efficiency of astronauts' work is impaired; and sometimes they are brought back to Earth, incurring the expense of their mission being aborted.  A Russian expedition to space in 1976 was returned to Earth after the cosmonauts reported a strong odor that resulted in a fear of fluid leakage; but after a thorough investigation, it became clear that there was no leakage or technical malfunction. It was concluded by NASA that the cosmonauts most likely had hallucinated the smell.
It is possible that the mental health of astronauts can be affected by the changes in the sensory systems while in prolonged space travel.
During astronauts' spaceflight, they are in an extreme environment. This, and the fact that little change is taking place in the environment, will result in the weakening of sensory input to the astronauts' seven senses.
- Hearing – In the space station and spacecraft there are no noises from the outside, as there is no medium that can transmit sound waves. Although there are other team members who can talk to each other, their voices become familiar and do not stimulate the sense of hearing as much. Mechanical noises become familiar, as well.
- Sight – Because of weightlessness, the body's liquids attain an equilibrium that is different from what it is on the Earth. For this reason, an astronaut's face swells and presses on the eyes; and therefore their vision is impaired. The landscape surrounding the astronauts is constant, which lessens visual stimulations. Due to cosmic rays, astronauts may see flashes.
- Smell – The space station has a permanent odor described as the smell of gunpowder. Due to the zero gravity, the bodily fluids rise to the face and prevent the sinuses from drying up, which dulls the sense of smell.
- Taste – The sense of taste is directly affected by the sense of smell and therefore when the sense of smell is dulled, the sense of taste is also. The astronauts' food is bland, and there are only certain foods that can be eaten. The food comes only once every few months, when supplies arrive, and there is little or no variety.
- Touch – There are almost no stimulating changes in physical contact. There is almost no human physical contact during the journey.
- The vestibular system (motion and equilibrium system) – Due to the lack of gravity, all the movements required of the astronauts are changed, and the vestibular system is damaged by the extreme change.
- The proprioception system (the sense of the relative position of one's own parts of the body and strength of effort being employed in movement) – As a result of weightlessness, few forces are exerted on the astronauts' muscles; and there is less stimulus to this system.
Space flight requires much higher velocities than ground or air transportation, and consequently requires the use of high energy density propellants for launch, and the dissipation of large amounts of energy, usually as heat, for safe reentry through the Earth's atmosphere.
Since rockets have the potential for fire or explosive destruction, space capsules generally employ some sort of launch escape system, consisting either of a tower-mounted solid-fuel rocket to quickly carry the capsule away from the launch vehicle (employed on Mercury, Apollo, and Soyuz, the escape tower being discarded at some point after launch, at a point where an abort can be performed using the spacecraft's engines), or else ejection seats (employed on Vostok and Gemini) to carry astronauts out of the capsule and away for individual parachute landings.
Such a launch escape system is not always practical for multiple-crew-member vehicles (particularly spaceplanes), depending on location of egress hatch(es). When the single-hatch Vostok capsule was modified to become the 2 or 3-person Voskhod, the single-cosmonaut ejection seat could not be used, and no escape tower system was added. The two Voskhod flights in 1964 and 1965 avoided launch mishaps. The Space Shuttle carried ejection seats and escape hatches for its pilot and copilot in early flights; but these could not be used for passengers who sat below the flight deck on later flights, and so were discontinued.
There have been only two in-flight launch aborts of a crewed flight. The first occurred on Soyuz 18a on 5 April 1975. The abort occurred after the launch escape system had been jettisoned when the launch vehicle's spent second stage failed to separate before the third stage ignited and the vehicle strayed off course. The crew finally managed to separate the spacecraft, firing its engines to pull it away from the errant rocket, both cosmonauts landing safely. The second occurred on 11 October 2018 with the launch of Soyuz MS-10. Again, both crew members survived.
In the first use of a launch escape system on the launchpad, before the start of a crewed flight, happened during the planned Soyuz T-10a launch on 26 September 1983, which was aborted by a launch vehicle fire 90 seconds before liftoff. Both cosmonauts aboard landed safely.
The only crew fatality during launch occurred on 28 January 1986, when the Space Shuttle Challenger broke apart 73 seconds after liftoff, due to failure of a solid rocket booster seal, which caused the failure of the external fuel tank, resulting in explosion of the fuel and separation of the boosters. All seven crew members were killed.
Despite the ever-present risks related to mechanical failures while working in open space, no spacewalking astronaut has ever been lost. There is a requirement for spacewalking astronauts to use tethers and sometimes supplementary anchors. If those fail, a spacewalking astronaut would most probably float away impelled by forces that were acting on the astronaut at the time of breaking loose. Such an astronaut would possibly be spinning, as kicking and flailing would be of no use. At the right angle and velocity, the astronaut might even re-enter the Earth's atmosphere and burn up. NASA has protocols for such situations: astronauts would be wearing an emergency jetpack that would automatically counter any tumbling. NASA's plan states that astronauts should then take manual control of the jetpack and fly back to safety.[ citation needed]
However, if the jetpack's 3 pounds (1.4 kg) of fuel runs out, and if there is no other astronaut in close proximity to help, or if the air lock is irreparably damaged, the outcome would certainly be fatal. At this time, there is no spacecraft to save an astronaut floating in space, as the only one with a rescue-ready air-locked compartment — the Space Shuttle — retired 9 years ago. There is approximately a litre of water available via straw in an astronaut's helmet. The astronaut would wait roughly 7.5 hours for breathable air to run out before dying of suffocation. 
On 1 February 2003, the crew of seven aboard the Space Shuttle Columbia were killed on reentry after completing a successful mission in space. A wing-leading-edge reinforced carbon-carbon heat shield had been damaged by a piece of frozen external tank foam insulation that had broken off and struck the wing during launch. Hot reentry gasses entered and destroyed the wing structure, leading to the breakup of the orbiter vehicle.
There are two basic choices for an artificial atmosphere: either an Earth-like mixture of oxygen and an inert gas such as nitrogen or helium, or pure oxygen, which can be used at lower than standard atmospheric pressure. A nitrogen–oxygen mixture is used in the International Space Station and Soyuz spacecraft, while low-pressure pure oxygen is commonly used in space suits for extravehicular activity.
The use of a gas mixture carries the risk of decompression sickness (commonly known as "the bends") when transitioning to or from the pure oxygen space suit environment. There have been instances of injury and fatalities caused by suffocation in the presence of too much nitrogen and not enough oxygen.
- In 1960, McDonnell Aircraft test pilot G.B. North passed out and was seriously injured when testing a Mercury cabin–space suit atmosphere system in a vacuum chamber, due to nitrogen-rich air leaking from the cabin into his space suit feed.  This incident led NASA to decide on a pure oxygen atmosphere for the Mercury, Gemini, and Apollo spacecraft.
- In 1981, three pad workers were killed by a nitrogen-rich atmosphere in the aft engine compartment of the Space Shuttle Columbia at the Kennedy Space Center Launch Complex 39. 
- In 1995, two pad workers were similarly killed by a nitrogen leak in a confined area of the Ariane 5 launch pad at Guiana Space Centre. 
A pure oxygen atmosphere carries the risk of fire. The original design of the Apollo spacecraft used pure oxygen at greater than atmospheric pressure prior to launch. An electrical fire started in the cabin of Apollo 1 during a ground test at Cape Kennedy Air Force Station Launch Complex 34 on 27 January 1967, and spread rapidly. The high pressure, increased by the fire, prevented removal of the plug door hatch cover in time to rescue the crew. All three astronauts— Gus Grissom, Ed White, and Roger Chaffee—were killed.  This led NASA to use a nitrogen–oxygen atmosphere before launch, and low pressure pure oxygen only in space.
The March 1966 Gemini 8 mission was aborted in orbit when an attitude control system thruster stuck in the on position, sending the craft into a dangerous spin that threatened the lives of Neil Armstrong and David Scott. Armstrong had to shut the control system off and use the reentry control system to stop the spin. The craft made an emergency reentry and the astronauts landed safely. The most probable cause was determined to be an electrical short due to a static electricity discharge, which caused the thruster to remain powered even when switched off. The control system was modified to put each thruster on its own isolated circuit.
The third lunar landing expedition, Apollo 13, in April 1970, was aborted and the lives of the crew— James Lovell, Jack Swigert, and Fred Haise—were threatened after the failure of a cryogenic liquid oxygen tank en route to the Moon. The tank burst when electrical power was applied to internal stirring fans in the tank, causing the immediate loss of all of its contents, and also damaging the second tank, causing the gradual loss of its remaining oxygen over a period of 130 minutes. This in turn caused loss of electrical power provided by fuel cells to the command spacecraft. The crew managed to return to Earth safely by using the lunar landing craft as a "life boat". The tank failure was determined to be caused by two mistakes: the tank's drain fitting had been damaged when it was dropped during factory testing, necessitating the use of its internal heaters to boil out the oxygen after a pre-launch test; which in turn damaged the fan wiring's electrical insulation because the thermostats on the heaters did not meet the required voltage rating due to a vendor miscommunication.
The crew of Soyuz 11 were killed on 30 June 1971 by a combination of mechanical malfunctions; the crew were asphyxiated due to cabin decompression following separation of their descent capsule from the service module. A cabin ventilation valve had been jolted open at an altitude of 168 kilometres (104 mi) by the stronger-than-expected shock of explosive separation bolts, which were designed to fire sequentially, but in fact had fired simultaneously. The loss of pressure became fatal within about 30 seconds. 
As of December 2015 [update], 23 crew members have died in accidents aboard spacecraft. Over 100 others have died in accidents during activity directly related to spaceflight or testing.
|Date||Mission||Accident cause||Deaths||Cause of death|
|27 January 1967||Apollo 1||Electrical fire in cabin, spread quickly by 16.7 psi (1.15 bar) pure oxygen atmosphere and flammable nylon materials in cabin and space suits, during pre-launch test; inability to remove plug door hatch cover due to internal pressure; rupture of cabin wall allowed outside air to enter, causing heavy smoke and soot||3||Cardiac arrest from carbon monoxide poisoning|
|15 November 1967||X-15 Flight 3-65-97||The accident board found that the cockpit instrumentation had been functioning properly, and concluded that Adams had lost control of the X-15 as a result of a combination of distraction, misinterpretation of his instrumentation display, and possible vertigo. The electrical disturbance early in the flight degraded the overall effectiveness of the aircraft's control system and further added to pilot workload.||1||Vehicle breakup|
|24 April 1967||Soyuz 1||Malfunction of primary landing parachute, and entanglement of reserve parachute; loss of 50% electrical power and spacecraft control problems necessitating emergency abort||1||Trauma from crash landing|
|30 June 1971||Soyuz 11||Loss of cabin pressurization due to valve opening upon Orbital Module separation before re-entry||3||Asphyxia|
|28 January 1986||STS-51L Space Shuttle Challenger||Failure of O-ring inter-segment seal in one Solid Rocket Booster in extreme cold launch temperature, allowing hot gases to penetrate casing and burn through a strut connecting booster to the External Tank; tank failure; rapid combustion of fuel; orbiter breakup from abnormal aerodynamic forces||7||Asphyxia from cabin breach, or trauma from water impact |
|1 February 2003||STS-107 Space Shuttle Columbia||Damaged reinforced carbon-carbon heat shield panel on wing's leading edge, caused by piece of External Tank foam insulation broken off during launch; penetration of hot atmospheric gases during re-entry, leading to structural failure of wing, loss of control and disintegration of orbiter||7||Asphyxia from cabin breach, trauma from dynamic load environment as orbiter broke up |
|31 October 2014||SpaceShipTwo VSS Enterprise powered drop-test||Copilot error: premature deployment of " feathering" descent air-braking system caused disintegration of vehicle in flight; pilot survived, copilot died||1||Trauma from crash|
- List of human spaceflight programs
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- List of crewed spacecraft
- Animals in space
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