In August 1878, local freemasons laid the cornerstone for a new brick building at the college, into which a time capsule was placed. Both U.S. Senator from Mississippi Lucius Quintus Cincinnatus Lamar II and Jefferson Davis were expected to attend the ceremony but were "unavoidably absent." 
In 1925 the College was first accredited by the Southern Association of Colleges and Schools.  In 1928 the College began operation as a two-year institution associated with Millsaps College in Jackson, Mississippi.  In 1938, because of financial difficulties, the board of trustees of the College voted to cease operations and merge the school with Millsaps College.  The city of Brookhaven bought the campus and leased it out to various short-lived colleges between 1941 and 1984, when all educational operations at the location ceased. 
During his term as Governor of Mississippi (1904-1908), white supremacist politician James Kimble Vardaman, known as the "Great White Chief," spoke at the college and was presented with a bouquet and the following poem:
TO THE "WHITE CHIEFTAIN."
White flowers to our chieftain white,
Brookhaven's daughters send;
To welcome him with glad delight
The Southland's truest friend.
Be not afraid! Thou white man's chief,
The Anglo-Saxon Race
Has yet to bend its neck beneath
A victor's cruel mace.
The blood is yours on land and sea
Uphold thro' its supremacy. 
- Lulah Ragsdale (1862-1953), poet, novelist and actor
- Nellie Nugent Somerville, first woman elected to the Mississippi Legislature 
- Patti Carr Black; Marion Barnwell (2002). Touring Literary Mississippi. Univ. Press of Mississippi. p. 110. ISBN 978-1-57806-367-3.
- "Renovation Funds in Housing Bill Old College Will Benefit". The Sun Herald. October 9, 1998. p. A14.
- Works Progress Administration; Robert S. McElvaine (2009). Mississippi: The WPA Guide to the Magnolia State. Univ. Press of Mississippi. p. 515. ISBN 978-1-60473-289-4.
- "Whitworth College Archive". Lincoln-Lawrence-Franklin-Regional Library. Retrieved January 22, 2014.
- Dan'l Dennett (August 25, 1878). "Agricultural. The Farm--Work-Shop--Factory-Home--School--Church". The Daily Picayune ( Times-Picayune). p. 10.
- "Arts school director retiring, MS". Associated Press News Service. May 25, 2009.
- Trent A. Watts (30 September 2010). One Homogeneous People: Narratives of White Southern Identity, 1890–1920. Univ. of Tennessee Press. p. 33. ISBN 978-1-57233-743-5.
- "Women Wielding Power-Mississippi". nwhm.org. Retrieved 21 September 2015.