|Motto||"The Leading University of Central Appalachia"|
|Endowment||$14.2 million |
|President||Dr. Burton Webb |
500 acres (202.3 ha)
|Colors||Orange and Black|
|Nickname||UPIKE, Bears, Lady Bears|
|Affiliations||NAIA Division I: MSC|
The University of Pikeville (nicknamed UPIKE and formerly known as Pikeville College) is a private, liberal arts university affiliated with the Presbyterian Church (USA), located in Pikeville, Kentucky, United States. The university is located on a 25-acre (10 ha) campus on a hillside overlooking downtown Pikeville. The university was founded in 1889 by the Presbyterian Church. Its current president is Dr. Burton Webb and the chancellor is former Governor of Kentucky and former university president Paul E. Patton. 
The university is home to the Kentucky College of Osteopathic Medicine, one of three medical schools in the state of Kentucky. The university confers associate, bachelor's, master's and doctorate degrees through its six academic divisions and one medical college; enrollment was 2,366 students in fall 2016. Its intercollegiate athletic teams, called the Bears, are members of the National Association of Intercollegiate Athletics at the NAIA Division I level and participate in the Mid-South Conference.
The university was founded in 1889 by the Presbyterian Church as the Pikeville Collegiate Institute. It operated on the primary, secondary and post-secondary levels, although its "college" offerings were not accredited and did not lead to a degree. 
In 1909 the school was split into the Pikeville College Academy, which was a private school at the primary and secondary level, and Pikeville College, which was accredited as a junior college, offering the first two-years with an anticipation of students then transferring to another Presbyterian college for a degree. In 1955 the school became a degree granting four-year college in its own right, and in 1957 the academy closed. 
In 1997, the Pikeville College School of Osteopathic Medicine, now the University of Pikeville Kentucky College of Osteopathic Medicine, was established. This makes the college one of the smallest colleges in the United States to have a medical school. 
The purpose of the osteopathic medical school, while graduates are fully prepared to specialize in any medical field, is to train primary care physicians to fill the shortage of medical care in the rural section of Appalachia in which it is located. Student recruitment is focused almost exclusively on students with a rural Appalachian background. It is one of 29 osteopathic colleges in the country, and one of five in Appalachia. 
On July 1, 2011, the school officially changed its name from "Pikeville College" to the "University of Pikeville".  Late in the same year, voices were raised in the Kentucky General Assembly in favor of converting the university into a state-supported school.  By the end of the following March, proponents abandoned their plans after deeming them politically impossible. 
- The Armington Learning Center – A building which houses all undergraduate math and science classes, undergraduate labs, various faculty offices, Chrisman Auditorium, the Chrisman Appalachian Research Institute.
- The Administration Building – The Administration Building houses the College of Education.
- The Allara Library – Dedicated in 1991, the Allara Library contains 3 floors of study rooms, books, a small cache of microfilm and microfiche, and the basement houses the University of Pikeville tutoring lab. The Allara Library was remodeled from the old Pikeville Hospital.
- The Coal Building – This building houses the University of Pikeville Kentucky College of Osteopathic Medicine.
- Health Professions Building – This building houses the University of Pikeville Kentucky College of Optometry.  Also, the building houses a Chick-fil-A and Einstein Bros. Bagels.
- Record Memorial – This building serves as a connection between Hambley Boulevard and University of Pikeville and also contains Booth Auditorium, the Sturgill Board Room, the Elizabeth Akers Nursing Program, the Marguerite Weber Art Gallery, and the Ridenour Dance Studio.
- Training-Academy Building – This is the oldest building on campus, and is listed on the National Register of Historic Places. It houses the Coleman College of Business.
- Derrianna Hall – Has always been a female dorm and houses upperclassmen females only.
- Condit Hall – Houses all freshman female students. The campus safety office is also located in Condit.
- Wickham Hall – Although originally a dorm for female campus residents it now houses all freshman males. The ground floor of the building holds the student lounge.
- Page Hall – Page Hall, like Wickham Hall, was originally a residence hall for female campus residents but now is a co-ed Hall and houses clubs and organizations that are registered with affinity housing.
- The Kinzer Residential Center – Kinzer Hall houses both male and female upperclassmen campus residents.
- Spilman Hall – Located next to Page Hall, Spillman is a Co-Ed dorm that also hold handicap dorms on the first level.
- UPIKE South – Formerly a hotel, UPIKE South is the first off-campus housing and is only offered to graduate students.
- Gillispie Hall – Located next to Kinzer Hall, Gillispie Hall houses honor freshman student.
- College Square Residence Hall – is a co-ed hall located by the campus gym.
The Marvin Student Center – The building housed the campus lounge, gameroom, post office, Upward Bound Program, and ROTC/National Guard Offices until it was demolished during the fall semester of 2010. A new building for the medical school called the Coal Building has been built in its place. The new $34 million educational facility is being dedicated on September 15, 2012. 
UPIKE's men's and women's basketball teams play at the 5,700-seat Eastern Kentucky Expo Center adjacent to the campus in downtown Pikeville.  The Expo Center opened in 2005 and replaced the UPike Gym as the home of the men's and women's basketball teams, although the women's volleyball team still uses the gym. The facility has also hosted the Mid-South Conference basketball tournament. 
The following majors are offered at the University of Pikeville: 
- Criminal Justice
- Computer Science
- Criminal Justice
- Early Elementary Education
- Film and Media Arts
- History/Political Science
- Interdisciplinary Studies
- Middle Grades Education
- Secondary Education
- Social Sciences
- Social Work
- Master of Business Administration
- Sport Management
The university's athletic teams are known as the Bears and Lady Bears. UPIKE is a member of the National Association of Intercollegiate Athletics (NAIA) and primarily competes in the Mid-South Conference (MSC). The university offers 20 sports; men's sports include baseball, basketball, bowling, cross country, football, golf, soccer, tennis and track & field; while women's sports include basketball, bowling, cheerleading, cross country, golf, soccer, softball, tennis, track & field and volleyball. 
- Grady Wallace – Attended in 1953–54 and 1954–55; went to the University of South Carolina afterward to play basketball and was named a consensus Second Team All-American and led the NCAA in scoring his senior season. 
- Donnie Jones – Graduated in 1988; former assistant and head basketball coach at Marshall University (1990–1996; 2007–2010, respectively) and assistant basketball coach at the University of Florida (1996–2007). He is currently the head basketball coach at the University of Central Florida. 
- Judi Patton – Former First Lady of Kentucky. Wife of current university chancellor and former governor Paul E. Patton. 
- John Paul Riddle – Graduated in 1920; Pioneer aviator and co-founder of the Embry-Riddle Aeronautical University. 
- Will T. Scott – Former Justice of Kentucky's 7th Supreme Court District. 
- E.J. Underwood – Former NFL, CFL, AFL and CIFL player.
- Walt Harris (fighter) – former basketball player, current mixed martial artist for the UFC 
- College Overview Retrieved on 2010-06-13
- As of fall 2016. "Student headcount by level: All independent institutions (2006–16)" (PDF). Kentucky Council on Postsecondary Education. Commonwealth of Kentucky. Retrieved 4 March 2018.
- History of Pikeville College Retrieved on 2010-06-13
- The other osteopathic colleges in Appalachia are located at:
- "Welcome – University of Pikeville". Pc.edu. Retrieved 2012-02-28.
- Estep, Bill; Musgrave, Beth (December 22, 2011). "Kentucky leaders discuss making University of Pikeville a state school". Lexington Herald-Leader. Retrieved February 10, 2012.
- Kiley, Kevin (March 15, 2012). "Turnabout in the Mountains". Inside Higher Ed. Retrieved 1 November 2012.
- UPIKE's New Health Professions Building Breaks Ground Southeast Kentucky Chamber of Commerce. Retrieved 2014-07-22.
- "Coal Building – University of Pikeville". Retrieved 5 September 2012.
- "About". Eastern Kentucky Expo Center. Retrieved February 10, 2012.
- Staff (January 23, 2006). "Community Trust Bank MSC basketball tournaments at Expo Center March 2–4". Floyd County Times. Retrieved February 10, 2012.
- Majors offered at Pikeville College Retrieved on 2010-06-13
- "About Pikeville Athletics". University of Pikeville. Retrieved February 10, 2012.
- "Athletic Highlights". University of Pikeville. Retrieved February 10, 2012.
- Staff (March 23, 2011). "Unseeded Pikeville wins NAIA championship game in overtime". CBS Sports. Retrieved February 10, 2012.
- Price, Tom (2001). Tales from the Gamecocks' Roost. United States: Sports Publishing, LLC. p. 56. ISBN 1-58261-342-7.
- "Pikeville College Graduate Donnie Jones takes over at UCF". WYMT-TV. March 30, 2010. Retrieved 2010-12-29.
- "Former Kentucky Governor Paul Patton Named Pikeville College President". Williamson (WV) Daily News. August 2009. Archived from the original on 2013-02-09. Retrieved 2010-12-29.
- John Paul Riddle 1901–1989 Historical Marker Society of America. Retrieved on 2010-12-29
- Profile for Will T. Scott Retrieved on 2010-12-29
- "Walt Harris – Official UFC® Fighter Profile". www.ufc.com. Retrieved 14 April 2018.