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|Length||220 mi[ citation needed] (354 km)|
|Existed||1989 (extended north in 2002,[ citation needed] south in 2005[ citation needed])–present|
|South end||US 61 / US 84 at Natchez, MS|
|I-20 at Rayville, LA|
|North end||I-530 / US 63 / US 65 / US 79 at Pine Bluff, AR|
|States||Mississippi, Louisiana, Arkansas|
U.S. Route 425 (US 425) is a north–south United States highway, first commissioned in 1989. Its route number is a "violation" of the usual AASHTO numbering scheme, as it comes nowhere near its implied "parent", US 25.
The route's northern terminus is in Pine Bluff, Arkansas, at an interchange with Interstate 530/ U.S. Route 63/ U.S. Route 65/ U.S. Route 79/ US 65B/ AR 190. Until 2005, its southern terminus was in Bastrop, Louisiana, at an intersection with U.S. Route 165. In 2005, it was extended to Natchez, Mississippi, at an intersection with U.S. Route 61. 
The southern terminus of US 425 is at a signalized intersection with US 61 and US 84 in Natchez. The route travels northwest through the city concurrent with US 84 to the Natchez–Vidalia Bridge, along which the two routes cross the Mississippi River into Louisiana.
After entering Louisiana, the concurrency with US 84 continues for approximately 14 miles to Ferriday. US 425 then splits and heads northeast, running concurrently with LA 15 through mostly farmland and small towns. Just north of Clayton is the southern terminus of US 65. Passing through Winnsboro the highways split at Archibald. LA 15 continues northwest to Monroe, LA while US 425 heads north to Rayville where it crosses I-20. At Mer Rouge, it intersects US 165 and the two highways run concurrent to Bastrop, LA. A few miles north of Bastrop, US 425 crosses into Arkansas south of Crossett.
The route enters Arkansas near Rawls and runs north through rural Ashley County. Highway 425 forms a concurrency with US 82 east of Crosett, with the two routes running north through farmland and trees to Hamburg, the county seat of Ashley County. In Hamburg, the routes are joined by Highway 8, which runs east and west across the southern part of the state.  North of the junction, the three routes pass the First United Methodist Church and historic properties within the Hamburg Commercial Historic District before US 82 turns east at St. Louis Street and US 425/AR 8 run north out of Hamburg. Passing more agricultural land, Highway 8 turns west in Fountain Hill just before the Drew County line.
Further north US 425 intersects Highway 133 in Lacey and Highway 172 before entering Monticello. The highway serves the University of Arkansas at Monticello in the southern part of town, also passing the Monticello Elementary School. US 425 intersects University Drive and continues north as a four–lane road. There is an interchange with Jordan Drive ( AR 83S), after which US 425 enters residential Monticello.  The route now curves to the west side of town, with Main Street (AR 83) serving downtown Monticello. Highway 83 was the previous alignment of AR 13, which US 425 replaced upon designation in 1989. There are plans to bypass Monticello even more efficiently as part of Interstate 69's extension into Arkansas.
US 425, now four–lane with center turn lane format,  intersects US 278/ Highway 35 at a busy intersection. Highway 35 forms a short concurrency north with US 425, which proceeds north and out of Monticello. After AR 35 turns west, Highway 425 has many rural junctions with county routes. Upon entering Lincoln County, the route passes the historic Mt. Zion Presbyterian Church in Relfs Bluff and the Parker House before entering Star City. Downtown, the highway forms a concurrency with Highway 11, which ends near the Lincoln County Courthouse and the Star City Commercial Historic District. The highway continues north through rural areas before intersecting US 65 in Jefferson County. US 65/US 425 run concurrent west to a high–volume interchange with I-530/ US 63/ US 79/ US 65B/ AR 190, where US 425 terminates.
In Arkansas, US 425 replaced the southern half of Arkansas Highway 13, which was an original state highway in the area. The route is essentially the same as it was at inception in the 1926 state highway plan, connecting the major cities in its area of southeast Arkansas. Highway 13 now runs in north central Arkansas. Most of US Route 425 was repaved in 2010 within Ashley County. 
|Location||Morehouse and Richland Parishes|
|Length||18.08 mi (29.10 km)|
Louisiana Highway 137 (LA 137) was a state highway in Louisiana that serves Richland Parish and Morehouse Parish. It spanned 18.08 miles (29.10 km) in a south to north direction. LA 137 is now signed as U.S. 425 for its entire length.
Passing under I-20, LA 137 met LA 3048 in the town of Rayville. After intersecting US 80, LA 137 entered Morehouse Parish, continuing north as a two-lane road until it swapped the U.S. 425 designation with LA 133.
LA 137 is a divided, four-lane highway south of Rayville, a pair of two one-way roads inside of Rayville, and an undivided, two-lane road north of Rayville. Before the 1955 renumbering, LA 137 was State Route 47 from Archibald to Rayville. The current routing for LA 137 did not exist, and travelers had to take US 80 west, then State Route 47 (Current LA 133) to Oak Ridge.
LA 137 was removed from the state highway system in 2005, when US 425 was extended south to Mississippi. It is still signed, however, as LA 137 and US 425.
This section contains a table that is missing mileposts for one or more junctions.
|Mississippi||Adams||Natchez||US 61 / US 84 east / US 98 east / Trace Town Drive – Vicksburg, Brookhaven, Woodville, Baton Rouge, Airport||south end of US 84 / US 61 Bus. overlap|
|Homochitto Street ( MS 928 / US 61 Bus. north) - Downtown Natchez||north end of US 61 Bus. overlap|
|Mississippi River||Natchez-Vidalia Bridge|
|Taconey||LA 3180 (J. Logan Sewell Drive)|
|Ferriday||US 84 west / LA 15 south / LA 568 – Jonesville||north end of US 84 overlap; south end of LA 15 overlap|
|LA 903 – Lake Concordia, Lake St. John|
|Clayton||US 65 north – Newellton, Tallulah, Lake Providence, Lake Bruin State Park|
|Tensas River||Tensas River Lift Bridge|
|Catahoula||Lee Bayou||LA 567|
|Sicily Island||LA 8|
|Franklin||Wisner||LA 562||south end of LA 562 overlap|
|LA 562||north end of LA 562 overlap|
|Gilbert||LA 128||south end of LA 128 overlap|
|LA 128||north end of LA 128 overlap|
|LA 4||south end of LA 4 overlap|
|LA 4 / LA 17 / LA 130||north end of LA 4 overlap|
|Richland||Mangham||LA 132||south end of LA 132 overlap|
|||LA 132||north end of LA 132 overlap|
|||LA 15 north||north end of LA 15 overlap; south end of LA 137 overlap|
|||LA 584||south end of LA 584 overlap|
|||LA 584||north end of LA 584 overlap|
|Rayville||LA 135 – Alto|
|I-20 – Monroe, Vicksburg||I-20 exit 138|
|LA 3048 east|
|Morehouse||||LA 133 south – Girard||north end of LA 137 overlap; south end of LA 133 overlap|
|Oak Ridge||LA 134 – Collinston, Monroe||south end of LA 134 overlap|
|LA 134 – Epps||north end of LA 134 overlap|
|||LA 3051 – Horseshoe Lake|
|Mer Rouge||LA 2 east – Oak Grove||north end of LA 133 overlap; south end of LA 2 overlap|
|US 165 north / LA 138 – Collinston, Bonita||south end of US 165 overlap|
|Bastrop||LA 830-3 (Peach Orchard Road)|
|LA 830-4 (Cooperlake Road)|
|LA 830-6 (McCreight Street)|
|LA 830-5 (Elm Street)|
|US 165 south / LA 2 west (West Madison) / LA 139 south / LA 593 south (South Washington)||north end of US 165 / LA 2 overlap; south end of LA 593 overlap|
|LA 830-1 (Harrington Avenue)|
|LA 593 north (Bonner Ferry Road) – Bussey Brake Reservoir||north end of LA 593 overlap|
|LA 830-3 (Cherry Ridge Road)|
|Log Cabin||LA 140|
|||LA 593 – Bussey Brake Reservoir|
|||LA 142 – Crossett, AR|
|||LA 1257 – Chemin-A-Haut State Park|
|Arkansas||Ashley||||9.4||15.1||US 82 west / AR 52 east – Crossett, El Dorado||south end of US 82 overlap|
|||12.0||19.3||AR 52 west – North Crossett, UAM College of Technology-Crossett|
|Hamburg||15.7||25.3||AR 189 west (West Jackson Street)|
|16.0||25.7||AR 8 east (East Parker Street) – Parkdale, Overflow NWR||south end of AR 8 overlap|
|16.2||26.1||AR 189 north (West Washington Street) to AR 133|
|16.3||26.2||US 82 east – Lake Village||north end of US 82 overlap|
|Fountain Hill||25.5||41.0||AR 8 west to AR 133 south – Johnsville, Crossett||north end of AR 8 overlap|
|26.0||41.8||AR 160 west|
|Drew||Lacey||32.8||52.8||AR 133 south to AR 160|
|White Hall||40.5||65.2||AR 172 west|
|||Monticello Bypass||under construction; future I-69 north|
|Monticello||42.7||68.7||AR 83 south (University Drive) – University of Arkansas Monticello|
|42.8||68.9||AR 83 north|
|45.4||73.1||US 278 – Warren, McGehee|
|||46.7||75.2||AR 35 north – Lake Monticello|
|Lincoln||||65.1||104.8||AR 54 east – Little Garnett|
|Star City||66.7||107.3||AR 293 south (Cane Creek Road) – Cane Creek State Park|
|67.2||108.1||AR 11 south (West Franklin Street)|
|67.8||109.1||AR 11 north / AR 114 west / AR 212 west (Arkansas Avenue / AR 11B south)|
|||77.8||125.2||AR 199 north / Allegiance Road – Tarry, Moscow|
|Jefferson||||88.5||142.4||US 65 south / AR 81 north – Grady, Lake Village||south end of US 65 overlap|
|Pine Bluff||90.5||145.6||AR 980 south – Airport|
|91.0||146.5||US 63 north / US 79 north / US 65B north / AR 190 – Downtown Pine Bluff||signed as exit 46|
|91.0||146.5||I-530 north ( US 63 south / US 65 north / US 79 south) – Little Rock||north end of US 65 overlap|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
- Sanderson, Dale End of U.S. Highway 425. Accessed 6 April 2011 (with maps of US 425 and related routes).[ self-published source]
- General Highway Map (PDF) (Map) (Ashley County ed.). Arkansas State Highway and Transportation Department. Retrieved June 24, 2011.
- General Highway Map (PDF) (Map) (Drew County ed.). Arkansas State Highway and Transportation Department. Retrieved June 24, 2011.
- Planning and Research Division (2010). "Arkansas Road Log Database". Arkansas State Highway and Transportation Department. Archived from the original (Database) on June 23, 2011. Retrieved June 9, 2011.
|Wikimedia Commons has media related to U.S. Route 425.|
|Browse numbered routes|
|← MS 424||MS||MS 427 →|
|← LA 136||LA (LA 137)||LA 138 →|
|← LA 424||LA (US 425)||LA 427 →|
|← US 412||AR||I-430 →|