|Auxiliary route of US 85|
|Length||1,206 mi (1,941 km)|
|Existed||1958[ citation needed]–present|
|South end||Big Bend National Park|
Fort Stockton, TX|
I-80 near Chappell, NE
|North end||US 85 at Deadwood, SD|
|States||Texas, Oklahoma, Colorado, Nebraska, South Dakota|
US 385 is designated as a part of the La Entrada al Pacifico trade corridor from Interstate 10 in Fort Stockton to Interstate 20 in Odessa. The section from Fort Stockton to McCamey is concurrent to US 67. From McCamey, the route proceeds to Crane in Crane County.
From Crane to Odessa, US 385 meets up with U.S. Highway 62 in Seminole, Texas and continues northward to Brownfield, Texas, where US 385 continues northward towards Levelland, Texas and crosses by Texas State Highway 86 in Dimmitt, Texas & U.S. Highway 84 in Littlefield, Texas. From Littlefield, US 385 continues northward until it crosses Interstate 40 and then goes in a half circle to Hartley, Texas where US 385 joins U.S. Highway 87. US 385 and US 87 follow a northwest track until the two meet U.S. Highway 54 and then split, with US 385 continuing northward until it exits Texas at the Oklahoma border.
On rural US 385, Speed limit is 75 mph in all counties going south of Gaines County starting between Seminole and Andrews down to US 90 in Marathon.
In Oklahoma, US-385 runs through Cimarron County at the end of the Oklahoma panhandle. Fourteen miles north of the border, it joins with US-56, US-64, and US-412. The three highways run northeast into the county seat, Boise City. In the middle of town, the highways come to a traffic circle surrounding the Cimarron County Courthouse. The traffic circle serves seven highways (with most passing through, forming the state's only six-way concurrency): U.S. Routes 56, 64, 287, 385 and 412, and State Highways 3 and 325. Every numbered highway in the county except one meets at this traffic circle.
After leaving the circle, US-385 heads northward, overlapping US-287 and SH-3, the state's longest state highway. SH-3 ends at the state line while US-287/385 continue north into Colorado.
The section of US-385 that overlaps SH-3 is also signed as Governor George Nigh's Northwest Passage, after the governor of Oklahoma responsible for improvements to the corridor.
U.S. 385 passes north–south through the easternmost counties of Colorado. It enters Colorado south of Campo on an overlap with U.S. Route 287. The overlap continues north until Lamar. At Lamar, the route turns east on an overlap with U.S. Route 50 and this overlap ends in Granada. The highway turns north at Granada and meets Interstate 70 at Burlington and Interstate 76 at Julesburg. The highway leaves Colorado northwest of Julesburg.
U.S. 385 passes north–south through the Nebraska Panhandle. It enters Nebraska south of Chappell and overlaps U.S. Route 30 between Chappell and Sidney. At Sidney, it turns north, meeting U.S. Route 26 at Bridgeport. It goes through Alliance before intersecting U.S. Route 20 at Chadron. It exits the state northwest of Chadron. Throughout its entire length in Nebraska, US 385 is known as the Gold Rush Byway, one of nine scenic byways in the state.
U.S. 385 enters South Dakota south of Oelrichs. It is overlapped with U.S. Route 18 between Oelrichs and Hot Springs. It turns north and enters Wind Cave National Park before turning west to go through Pringle. At Custer, it begins an overlap with U.S. Route 16, which ends near Hill City. It gradually turns northwesterly and ends at an intersection with U.S. Route 85 at Deadwood.
Legally, the South Dakota section of U.S. 385, with the exception of concurrencies with U.S. 18 and U.S. 16 and a gap at Wind Cave National Park, is defined at South Dakota Codified Laws § 31-4-235. 
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The current US 385 first appeared in 1959.   Originally, the route continued along US 287 north of Lamar, Colorado, splitting in Kit Carson to follow US 40 east to meet up with the present-day alignment in Cheyenne Wells. 
In South Dakota, in 2009, the South Dakota Department of Transportation designated US 16/US 385 between Custer and Hill City, which passes by the Crazy Horse Memorial, now being carved in the Black Hills. This segment of US 385 is also a part of the George Hearst Memorial Highway.
- The north entrance to Big Bend National Park south-southeast of Marathon
- US 90 in Marathon. The highways travel concurrently to east of Marathon.
- US 285 in Fort Stockton. The highways travel concurrently through Fort Stockton.
- I‑10 / US 67 in Fort Stockton. I-10/US 385 travels concurrently to east-southeast of Fort Stockton. US 67/US 385 travels concurrently to McCamey.
- I‑20 in Odessa
- US 62 / US 180 in Seminole. US 62/US 385 travels concurrently to Brownfield.
- US 82 / US 380 in Brownfield. The highways travel concurrently through Brownfield.
- US 84 in Littlefield
- US 70 in Springlake
- US 60 in Hereford
- I‑40 in Vega
- US 87 in Hartley. The highways travel concurrently to Dalhart.
- US 54 in Dalhart
- US 56 / US 64 / US 412 southwest of Boise City. The highways travel concurrently to Boise City.
- US 287 north of Boise City. The highways travel concurrently to Lamar, Colorado.
- US 160 south of Springfield
- US 50 / US 287 in Lamar. US 50/US 385 travels concurrently to Granada.
- US 50 / US 400 in Granada
- US 40 in Cheyenne Wells. The highways travel concurrently to east of Cheyenne Wells.
- I‑70 in Burlington
- US 24 in Burlington. The highways travel concurrently through Burlington.
- US 36 east of Idalia. The highways travel concurrently to northeast of Idalia.
- US 34 in Wray
- US 6 in Holyoke
- I‑76 in Julesburg
- US 138 in Julesburg. The highways travel concurrently to west-southwest of Julesburg.
- US 30 in Chappell. The highways travel concurrently to Sidney.
- US 26 in Bridgeport. The highways travel concurrently to Northport.
- US 20 in Chadron. The highways travel concurrently to west of Chadron.
- South Dakota
- US 18 in Oelrichs. The highways travel concurrently to Hot Springs.
- US 16 in Custer. The highways travel concurrently to east-northeast of Hill City.
- US 85 in Deadwood
|Browse numbered routes|
|← US 380||TX||I-410 →|
|← US-377||OK||US-412 →|
|← N-370||NE||I-480 →|
|← SD 377||SD||SD 391 →|