US 159 highlighted in red
|Auxiliary route of US 59|
[a] (134.5 km)|
|Existed||1935[ citation needed]–present|
US-59 / K-4 Alt. in Nortonville, KS
|North end||US 59 in New Point, MO|
|States||Kansas, Nebraska, Missouri|
U.S. Highway 159 (US 159) is a 83.6-mile-long (134.5 km) auxiliary route of US 59. It travels from Nortonville, Kansas at US 59 to New Point, Missouri, also at US 59. The highway permits through traffic on US 59 to bypass the cities of Atchison, Kansas and Saint Joseph, Missouri.
US 159 clips the far southeastern corner of Nebraska. It enters south of Falls City concurrently with U.S. Route 73. In Falls City, US 159 turns east. It leaves the state at the Missouri River bridge in Rulo.
When the route was commissioned in 1934, U.S. Route 159 only went between Nortonville, Kansas and Horton, Kansas. In 1945, it was extended north to Craig, Missouri via Falls City, Nebraska. After 1975, the route in Missouri was altered to go east from the Fortescue area to what is now its current terminus near New Point, Missouri. The old route which went to Craig is now Route 111. 
  
K-4 Alt. begins / US-59 – Atchison, Topeka
|South end of K-4 Alt. overlap|
K-4 Alt. west (Osage Street)
|North end of K-4 Alt. overlap|
|Atchison||Center Township||3.6||5.8||K-116 east||South end of K-116 overlap|
|4.3||6.9||K-116 west||North end of K-116 overlap|
|8.7||14.0||K-9 east||South end of K-9 overlap|
|Grasshopper Township||22.7||36.5||K-9 west||North end of K-9 overlap|
|Brown||Horton||28.3||45.5||US-73 south / K-20 east (15th Street)||South end of US-73/K-20 overlap|
|28.4||45.7||K-20 west (15th Street)||North end of K-20 overlap|
|Hiawatha||40.3||64.9||US-36 – Seneca, Troy||Interchange|
|Kansas–Nebraska state line|
|Nebraska||Richardson||Falls City||4.11||6.61||US 73 north (Harlan Street)||North end of US 73 overlap|
|Nebraska–Missouri state line|
|Missouri||Holt||Big Lake||13.248||21.321||Route 111 north (Lake Shore Drive)||South end of Route 111 overlap|
|Minton Township||7.771||12.506||Route 111 south||North end of Route 111 overlap|
|I-29 – St. Joseph, Council Bluffs||Exit 79 along I-29|
|Hickory Township||0.000||0.000||US 59 – Mound City, Oregon|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
- Total mileage is the sum of each state's length
- Sanderson, Dale End of US highway 159.
- Laukaitis, Algis J. (January 19, 2014). "Span of historic Rulo bridge destroyed". Lincoln Journal Star. Lee Enterprises. Retrieved October 1, 2016.
- "County Maps". Kansas Department of Transportation. Retrieved July 13, 2012.
- "Nebraska Highway Reference Log Book" (PDF). Nebraska Department of Roads. 2015. p. 281. Retrieved January 8, 2017.
- Missouri Department of Transportation (July 13, 2012). MoDOT HPMAPS (Map). Missouri Department of Transportation. Retrieved July 13, 2012.
|Browse numbered routes|
|← K-156||KS||US-160 →|
|← US 138||NE||I-180 →|
|← Route 158||MO||US 160 →|