Southern Oregon is a region of the U.S. state of Oregon south of Lane County and generally west of the Cascade Range, excluding the southern Oregon Coast. Counties include Douglas, Jackson, Klamath, and Josephine. It includes the Southern Oregon American Viticultural Area, which consists of the Umpqua and Rogue River drainages. As of 2015, the population in the four counties is about 471,000, and in the greater, seven-county definition is about 564,000.  
- Jackson County; population 212,567 
- Douglas County; population 107,685 
- Josephine County; population 84,745 
- Klamath County; population 66,016 
Total population: 471,013
- Coos County; population 63,121 
- Curry County; population 22,483 
- Lake County; population 7,829 
Total population (7 counties): 564,446
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Southern Oregon generally supports candidates of the Republican Party; besides Jackson County, which is considered a swing county, no Democrat has won any county of southern Oregon in presidential elections since 1996 using the seven-county definition, or since 1964 using the four-county definition. Josephine County has not supported a Democrat for president since 1936.
|Wikivoyage has a travel guide for Southern Oregon.|
- "County Totals Dataset: Population, Population Change and Estimated Components of Population Change: April 1, 2010 to July 1, 2015". Archived from the original on July 8, 2016. Retrieved July 2, 2016.