The college includes three campuses and more than 20 off-campus sites in 15 counties. The campuses are located in the following cities:
- Lincoln, Nebraska (9,000 students)
- Beatrice, Nebraska (900+ students)
- Milford, Nebraska (900 students)
SCC-Lincoln includes three main locations, all located off O Street. The campus at 8800 and 1111 streets is open to all students, while the Continuing Education Center at 68th Street Place is intended mainly for alumni, business professionals and entrepreneurs, and features classes, workshops and seminars. City buses transport some students between the primary campus and Energy Square.
SCC also offers online learning for more than 300 courses each term.
The two-year Academic Transfer program is popular amongst students wanting to get their general education requirements completed before moving to a four-year institution as a Junior. UNL is the most popular transfer location for SCC Academic Transfer students, and SCC is UNL's largest feeder. There is a 1:1 class credit transfer ratio between SCC and UNL, with SCC quarter credits being translated into the equivalent of UNL semester credits. Other popular transfer locations include Doane and Nebraska Wesleyan.
SCC originally opened in 1941 as Fairbury Junior College in Fairbury, Nebraska, suspending operations during World War II and reopening in 1946. Southeast Community College was organized in 1973 with campuses in Fairbury, Lincoln, and Milford. In 1975, Southeast took over the Beatrice campus of John J. Pershing College, which had closed in 1971. In 1980, the agriculture program moved from the Milford campus to Beatrice. In 1986, the original Fairbury location was shuttered and merged into the Beatrice campus. 
- Dana Altman, college basketball coach
- Patrick Bourne, former Nebraska state senator
- Catherine Kidwell, novelist