The Secotans were one of several groups of American Indians dominant in the Carolina sound region, between 1584 and 1590, with which English colonizers had varying degrees of contact. Secotan villages included the Secotan, Aquascogoc, Dasamongueponke, Pomeiock ( Pamlico) and Roanoac.  Other local groups included the Chowanoke (including village Moratuc), Weapemeoc, Chesapeake, Ponouike, Neusiok, and Mangoak (Tuscarora), and all resided along the banks of the Albemarle and Pamlico sounds.  They spoke Carolina Algonquian language, an Eastern Algonquian language.
In the Carolinas, colonization did not exist as a straight-line transition, from Native American to European rule. A rivalry marked the relationship between the two European powers, the English and the Spanish. Rivalries also existed between the Native American groups. Additionally, the Europeans often found themselves caught in the middle of conflicts, which existed between Native American groups. Each group, European or Native American placed the interest of their group over the interest of all others. The English, the Spanish, and the Native American groups they had contact with each acted against the others, as counter-colonizers of the Carolinas as exhibited through the study of Roanoke Island.
In 1490, prior to England's entry into North American colonialism, the Treaty of Medina del Campo lowered tariffs between England and Spain, and ushered in an era of increased trading between the two countries. The marriage of Henry VIII of England and Catherine of Aragon (Spain) sealed the treaty. During this time, many English traders moved to southern Spain, in the area of Andalusia, and trade flourished. In 1533, Spanish officials began to harass the English in Spain, who were required as Englishmen to "swear under oath" that Henry VIII was the head of the church. The requirement of the oath made the Englishmen in Spain subject to persecution, under charges of heresy, by the Spanish Inquisition. 
To circumvent Spanish officials and the inquisition, English traders devised a system, in which they would travel to Spanish possessions in the Caribbean, to pick up Spanish goods, and take them back to England, with no religious conflicts. By the 1560s, the English faced increasing Spanish hostility. In 1585, the Englishman Richard Hakluyt published a book, Discourse of Western Planting, which concluded that the English should establish their own colony in the mid-latitudes of North America, to end dependency on Spanish goods, by creating their own supply lines. By April of the same year, Sir Richard Grenville left England, bound for the Carolina coast, with 100 colonists, which marked the beginning of England's colonial endeavours in America. 
Spanish colonies established the first European colonies in the Carolinas, under the leadership of Spanish captain, Juan Pardo, in 1567 and 1568. Pardo declared that the Catawba, Wateree, and Saxaphaw groups were subject to the Spanish crown, and he successfully persuaded the groups to construct housing and make food provisions, which created eleven Spanish settlements in the Carolinas. The Spanish still inhabited the Carolinas when the English arrived. 
While the Spanish settled in the interior of the Carolinas, the English arrived on the coast. The placement of a colony at Roanoke marked the first English colonial presence in North America. 
Before the English placed their first settlement on Roanoke Island, Master Philip Amadas and Master Arthur Barlowe executed an expedition on April 27, 1584, on behalf of Sir Walter Raleigh, who received an English charter, to establish a colony a month earlier. During their expedition, Barlowe took detailed notes relating to conflicts and rivalries between different groups of Native Americans.  In one such account, Wingina, the wereoance or chief of the Secotans, explained his own tribal history, in relation to a neighboring tribe at the mouth of the Neuse River, the Neusiok, referred to as the Neiosioke by Barlowe. According to Wingina, the Secotans endured years of warfare with the Neiosioke, and "some years earlier," he met with the Neiosioke king, in an effort to ensure a "permanent coexistence." The two leaders arranged a feast between the two groups. An unspecified number of Secotan men and thirty women attended a feast in the town of Neiosioke. The Neiosioke executed an ambush on the Secotans at the feast, and by the time fighting ended, the Neiosioke had "slewn them every one, reserving the women and children only." 
In conveying this "inter-tribal" history to Barlowe, Wingina saw an opportunity to advance the interest of the Secotans. Wingina and his people attempted on several occasions to convince the English to join them in devising a surprise attack against the Neiosioke. The Englishmen, uncertain of "whether their perswasion be to the ende they may be revenged of their enemies, or for the love they beare to us," declined to help the Secotans wage war against their rivals. Instead, the English established a trusting relationship with the Secotans, exemplified by the willingness of two Secotan men, Manteo and Wanchese, to accompany Amadas and Barlowe back to England. 
The Secotan remained in the same area until 1644-5, when they were attacked and driven off by colonists from Virginia Colony during the last of the Anglo-Powhatan Wars. English settlement in the area began to increase soon afterwards, and it was officially transferred from Virginia Colony to the Province of Carolina in 1665. In latter years Secotans were recorded under the name Machapunga. 
- Algonquian languages
- Algonquian peoples
- Carolina Algonquian
- Chesapeake (tribe)
- Miller 2000, pp. 265–266
- Names of geographic features and Native American groups have changed over time. The English knew the Albemarle and Pamlico sounds as the Roanoke Sea. The English knew the location of the Mangoaks, but according to the depositions collected from 1707-1711, the Tuscarora initiated the sale of the same lands to the Weapemeoc in 1645. This provides evidence f. Huhyhurfthat the Tuscarora and Mangoak existed as names for the same group of people. Many commonly used tribe names actually refer to individual villages, which existed within tribes. The Secotan tribal area included the villages of both Roanoke and Croatan, though many sources inaccurately refer to theses villages as separate Native American groups. Bernard G. Hoffman, "Ancient Tribes Revisited: A summary of Indian distribution and movement in the North Eastern United States from 1534 to 1779, Parts I-III." Ethnohistory, 14, no. 1 / 2 (1967): 30.
- Paul E. Hoffman, Spain and the Roanoke Voyages (Raleigh: Division of Archives and History; North Carolina Department of Cultural Resources, 1987), 18-19.
- Paul E. Hoffman, Spain and the Roanoke Voyages, 18-19.
- Marion P. Blackburn, "Spain's Appalachian Outpost". Archaeology 62, no 4 (2009): 38-43.
- David Stick, Roanoke Island: The Beginnings of English America (Chapel Hill: The University of North Carolina press, 1983), 30-32.
- Paul E. Hoffman, Spain and the Roanoke Voyages, 26-27.
- Stick, Roanoke Island: The Beginnings of English America, 36, 42, 50-51.
- Stick, Roanoke Island: The Beginnings of English America, 51-52.
- Karen Ordahl Kupperman, Roanoke: The Abandoned Colony
- Roanoke: Solving the Mystery of the Lost Colony, Lee Miller
- Roanoke: The Abandoned Colony, Second Edition, Karen Ordahl Kupperman
- Map of Virginia colony 1585. and Secotan territory
- Miller, Lee. "Roanoke: Solving the Mystery of the Lost Colony". New York, Arcade Publishing, 2000. Print.
- Hoffman, Paul E., Spain and the Roanoke Voyages (Raleigh: Division of Archives and History; North Carolina Department of Cultural Resources, 1987), 18-19.
- Kupperman, Karen Ordahl. Indians and English: Facing Off in Early America. Ithaca: Cornell University Press, 2000.
- Mancall, Peter C. Hakluyt's Promise: An Elizabethan’s Obsession for an English America. New Haven: Yale University Press, 2007.
- Milton, Giles, Big Chief Elizabeth - How England's Adventurers Gambled and Won the New World, Hodder & Stoughton, London (2000)
- Vaughan, Alden T. "Sir Walter Raleigh's Indian Interpreters, 1584-1618." The William and Mary Quarterly 59.2 (2002): 341-376.
- Karen Ordahl Kupperman, "Roanoke: The Abandoned Colony", Second Edition, Rowman&Littlefield Publishers Inc. ISBN 978-0-7425-5263-0