Sangre de Cristo National Heritage Area is a federally designated National Heritage Area in the south central portion of the U.S. state of Colorado. The heritage area includes the San Luis Valley and portions of the Sangre de Cristo Range. The region combines influences of Anglo-American, Hispano-American and Native American influences. It also includes portions of the upper Rio Grande valley. 
The national heritage area includes Alamosa, Costilla, and Conejos counties, and portions of Saguache and Rio Grande counties.  It also includes within its boundaries Great Sand Dunes National Park and Preserve, Baca National Wildlife Refuge, the Sangre de Cristo Wilderness, the South San Juan Wilderness, Sangre de Cristo Wilderness Area, San Luis Wilderness Study Area, Monte Vista National Wildlife Refuge, Alamosa National Wildlife Refuge and the Medano-Zapata Ranch. 
The national heritage area was established to preserve and promote the region's distinctive cultural and natural features. The San Luis Valley was culturally isolated for much of its history, preserving a distinctive local Spanish dialect and vocabulary. A high proportion of the local population is descended from Hispanos, Spanish colonial settlers who arrived in the area in the 1800s, the first European settlers in Colorado. 
- "Home". Sangre de Cristo National Heritage Area. Retrieved 25 April 2012.
- Heritage Strategies LLC. "Sangre de Cristo National Heritage Area Boundary Map" (PDF). Sangre de Christo National Heritage Area. Archived from the original (PDF) on 20 May 2014. Retrieved 25 April 2012.
- "Protected Lands". Sangre de Cristo National Wildlife Refuge. Archived from the original on 20 January 2014. Retrieved 25 April 2012.
- Harrison, Carlos. "Sangre de Cristo". Preservation (Summer 2012): 53–58.