Safflower (Carthamus tinctorius) is a highly branched, herbaceous, thistle-like annual plant. It is commercially cultivated for vegetable oil extracted from the seeds and was used by the early Spanish colonies along the Rio Grande river as a substitute for saffron.  Plants are 30 to 150 cm (12 to 59 in) tall with globular flower heads having yellow, orange, or red flowers. Each branch will usually have from one to five flower heads containing 15 to 20 seeds per head. Safflower is native to arid environments having seasonal rain. It grows a deep taproot which enables it to thrive in such environments.
Safflower is one of humanity's oldest crops. Chemical analysis of ancient Egyptian textiles dated to the Twelfth Dynasty identified dyes made from safflower, and garlands made from safflowers were found in the tomb of the pharaoh Tutankhamun.  John Chadwick reports that the Greek name for safflower κάρθαμος (kārthamos) occurs many times in Linear B tablets, distinguished into two kinds: a white safflower (ka-na-ko re-u-ka, 'knākos leukā'), which is measured, and red (ka-na-ko e-ru-ta-ra, 'knākos eruthrā') which is weighed. "The explanation is that there are two parts of the plant which can be used; the pale seeds and the red florets." 
The early Spanish colonies along the Rio Grande River in New Mexico used safflower as a substitute for saffron in traditional recipes. An heirloom variety originating in Corrales, New Mexico, called "Corrales Azafran", is still cultivated and used as a saffron substitute in New Mexican cuisine. 
Traditionally, the crop was grown for its seeds, and used for coloring and flavoring foods, in medicines, and making red ( carthamin) and yellow dyes, especially before cheaper aniline dyes became available.  For the last fifty years or so, the plant has been cultivated mainly for the vegetable oil extracted from its seeds.
Safflower seed oil is flavorless and colorless, and nutritionally similar to sunflower oil. It is used mainly in cosmetics and as a cooking oil, in salad dressing, and for the production of margarine. INCI nomenclature is Carthamus tinctorius.
There are two types of safflower that produce different kinds of oil: one high in monounsaturated fatty acid ( oleic acid) and the other high in polyunsaturated fatty acid ( linoleic acid). Currently the predominant edible oil market is for the former, which is lower in saturated fats than olive oil. The latter is used in painting in the place of linseed oil, particularly with white paints, as it does not have the yellow tint which linseed oil possesses.[ citation needed]
The dried safflower petals are also used as a herbal tea variety.
In coloring textiles, dried safflower flowers are used as a natural dye source for the orange-red pigment carthamin.   Carthamin is also known, in the dye industry, as Carthamus Red or Natural Red 26. 
In Japan, dyers have mastered the technique of producing a bright red to orange-red dye (known as carthamin) from the dried florets of safflower ( Carthamus tinctorius). A bath solution of cold water is first prepared, to which is added the collected flowers. Steeping in cold water releases a yellow pigment ( colorant) which, after straining, is discarded. After pressing and drying once again the red petals, the petals are re-hydrated again, at which time alkali made from straw-ash is added to release the red colorant. The batch is then kneaded with one's hands and strained. Vinegar is then added to the solution, and the colorant is soaked up by using strips of linen. The strips of linen (now red) are then placed in a separate container and alkali is added once more to release the red absorbed by the linen. The solution obtained is then poured into a separate container. An extract made from a type of plum causes the colorant to precipitate onto a piece of silk. The colorant at this stage has the consistency of fine, red mud. Color used as a dye can be diluted.  1.5 kilograms (3.3 lb) of dried florets produces enough dye pigment to dye a small piece of fabric. The dye color is fixed in the fabric with a mordant. Darker shades are achieved by repeating the dyeing process several times, having the fabric dry, and redyed.
In preliminary research where high-linoleic safflower oil replaced animal fats in the diets of people with heart disease, the group receiving safflower oil in place of animal fats had a significantly higher risk of death from all causes, including cardiovascular diseases. 
- "Tropicos". Missouri Botanical Garden, St. Louis, MO. 2016. Retrieved 16 June 2016.
- "Corrales Azafrán - Native-Seeds-Search". shop.nativeseeds.org.
- Daniel Zohary, Maria Hopf, Ehud Weiss (2012). Domestication of Plants in the Old World: The Origin and Spread of Domesticated Plants in Southwest Asia, Europe, and the Mediterranean Basin, 4th edition, page 168. Oxford University Press. ISBN 978-0199549061.CS1 maint: Uses authors parameter ( link)
- John Chadwick, The Mycenaean World (Cambridge: University Press, 1976), p. 120
- "World production of safflower seeds in 2016; Browse World Regions/Crops/Production from pick lists". United Nations Food and Agriculture Organization, Statistics Division (FAOSTAT). 2017. Retrieved 4 December 2018.
- E.g. "safflower" in Webster's Dictionary, year 1828. E.g. "bastard saffron" in The Herball, or General Historie of Plantes, by John Gerarde, year 1597, pages 1006-1007.
- Dweck, Anthony C. (ed.) (June 2009), Nature provides huge range of colour possibilities (PDF), Personal Care Magazine, pp. 61–73, retrieved 30 Oct 2012CS1 maint: Extra text: authors list ( link)
- "Carthamus red; In: Compendium of Food Additive Specifications. Addendum 5. (FAO Food and Nutrition Paper - 52 Add. 5)". FAO/WHO Expert Committee on Food Additives. 1997. Retrieved September 20, 2016.
- Victoria and Albert Museum, Sachio Yoshioka, on YouTube, katakana (紅) Beni Red (safflower; carthamus tinctorius) / June 2018, minutes 5:22–9:45
- Ramsden, C. E.; Zamora, D.; Leelarthaepin, B.; Majchrzak-Hong, S. F.; Faurot, K. R.; Suchindran, C. M.; Ringel, A.; Davis, J. M.; Hibbeln, J. R. (2013). "Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: Evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis". BMJ. 346: e8707. doi: 10.1136/bmj.e8707. PMC 4688426. PMID 23386268.
|Wikimedia Commons has media related to Carthamus tinctorius.|
- Safflower field crops manual, University of Wisconsin, 1992
- The Paulden F. Knowles personal history of safflower germplasm exploration and use, University of California-Davis, Department of Plant Sciences
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