This is a list of the National Register of Historic Places listings in Guadalupe County, Texas.
This is intended to be a complete list of properties and districts listed on the National Register of Historic Places in Guadalupe County, Texas. There are two districts and 12 individual properties listed on the National Register in the county. Two individually listed properties are State Antiquities Landmarks including one along with five other properties that are designated Recorded Texas Historic Landmarks. One district includes an additional Recorded Texas Historic Landmark.
The publicly disclosed locations of National Register properties and districts may be seen in a mapping service provided. 
|||Name on the Register ||Image||Date listed ||Location||City or town||Description|
|1||Dublin Plantation||December 11, 2013
|3135 Cottonwood Creek Road||Kingsbury vicinity||Recorded Texas Historic Landmark|
|2||Erskine House No. 1||August 25, 1970
|902 N. Austin St.||Seguin||Recorded Texas Historic Landmark|
|3||Robert Hall House||October 25, 1979
|214 S. Travis St.||Seguin|
|4||Hardscramble||July 6, 2011
|1806 Tschoepe Rd.||Seguin vicinity|
|5||Joseph F. Johnson House||June 23, 1978
|761 Johnson Ave.||Seguin|
|6||King-Woods Farmstead||April 2, 2018
|920 E Court St.||Seguin|
|7||Los Nogales||March 24, 1972
|S. River and E. Live Oak Sts.||Seguin||Recorded Texas Historic Landmark|
|8||Park Hotel||May 23, 1980
|217 S. River St.||Seguin|
|9||Saffold Dam||November 15, 1979
|Off TX 123||Seguin||State Antiquities Landmark|
|10||Sebastopol||August 25, 1970
|NE corner of W. Court and N. Erkel Sts.||Seguin||State Antiquities Landmark, Recorded Texas Historic Landmark|
|11||Seguin Commercial Historic District||December 15, 1983
August 14, 2013 boundary increase ( #03000768)
|Roughly bounded by Camp, Myrtle, Washington, and Crockett Sts.||Seguin||Includes Recorded Texas Historic Landmark; 70 buildings, 1 structure, 1875-1949; boundary increase in 2013 added 9 buildings.|
|12||State Highway 3-A Bridge at Cibolo Creek||October 10, 1996
|I-10 at the Bexar and Guadalupe Cnty. line||Schertz||Extends into Bexar County|
|13||Sweet Home Vocational and Agricultural High School||November 19, 1998
|10 mi (16 km). S of Seguin on Sweet Home Rd.||Seguin||Recorded Texas Historic Landmark|
|14||Edward and Texanna Tewes House||January 9, 1997
|8280 Linne Rd.||Seguin||Recorded Texas Historic Landmark|
|15||Wilson Utility Pottery Kilns Archeological District||April 16, 1975
||Capote||Roadside historical marker located outside district|
- National Register of Historic Places listings in Texas
- Recorded Texas Historic Landmarks in Guadalupe County
- "National Register of Historic Places: Weekly List Actions". National Park Service, United States Department of the Interior. Retrieved on March 22, 2019.
- The latitude and longitude information provided in this table was derived originally from the National Register Information System, which has been found to be fairly accurate for about 99% of listings. For about 1% of NRIS original coordinates, experience has shown that one or both coordinates are typos or otherwise extremely far off; some corrections may have been made. A more subtle problem causes many locations to be off by up to 150 yards, depending on location in the country: most NRIS coordinates were derived from tracing out latitude and longitudes from USGS topographical quadrant maps created under the North American Datum of 1927, which differs from the current, highly accurate WGS84 GPS system used by most on-line maps. Chicago is about right, but NRIS longitudes in Washington are higher by about 4.5 seconds, and are lower by about 2.0 seconds in Maine. Latitudes differ by about 1.0 second in Florida. Some locations in this table may have been corrected to current GPS standards.
- Numbers represent an ordering by significant words. Various colorings, defined here, differentiate National Historic Landmarks and historic districts from other NRHP buildings, structures, sites or objects.
- National Park Service (2010-07-09). "National Register Information System". National Register of Historic Places. National Park Service.
- The eight-digit number below each date is the number assigned to each location in the National Register Information System database, which can be viewed by clicking the number.
- Federal and state laws and practices restrict general public access to information regarding the specific location of this resource. In some cases, this is to protect archeological sites from vandalism, while in other cases it is restricted at the request of the owner. See: Knoerl, John; Miller, Diane; Shrimpton, Rebecca H. (1990), Guidelines for Restricting Information about Historic and Prehistoric Resources, National Register Bulletin (29), National Park Service, U.S. Department of the Interior, OCLC 20706997.
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