The MLSC invests in biotech research at four Michigan institutions: the University of Michigan in Ann Arbor; Michigan State University in East Lansing; Wayne State University in Detroit; and the Van Andel Institute in Grand Rapids.
The Michigan Economic Development Corporation administers the program. It began in 1999 with money from the state's settlement with the tobacco industry. When the program's funds distributions are completed in 2019, the goal is that the investments in high tech research will have notably expanded the state's economic base.
In 1998, the State of Michigan, along with 45 other states, reached the $8.5 billion Tobacco Master Settlement Agreement, a settlement with the U.S. tobacco industry.  Former Governor John Engler created the Michigan Life Sciences Corridor in 1999 when he signed Public Act 120 of 1999.  The bill appropriated money from the state's settlement with the tobacco industry to fund biotech research at four of Michigan's largest research institutions. 
Under the management of the Michigan Economic Development Corporation, the MLSC allocated $1 billion over the course of 20 years, including $50 million in 1999 to fund research on aging.  The following year, the MLSC awarded $100 million to 63 Michigan universities.  In 2002, Governor Jennifer Granholm incorporated the MLSC into the Michigan Technology Tri-Corridor, adding funding for homeland security and alternative fuel research. 
- O'Connor, Julie. " Wayne State major participant in Michigan Life Sciences Corridor research Archived 2006-07-18 at the Wayback Machine".
- Michigan Public Act 120 of 1999.
- Truscott, John. " Governor Signs Bill Creating "Life Sciences Corridor" in Michigan Archived 2013-05-20 at the Wayback Machine". Michigan Executive Office press release. July 19, 1999.
- MLSC Background and History.
- McMahon, Kathleen. " First Round of Life Sciences Corridor Funds Awarded[ permanent dead link]". Michigan Economic Development Corporation press release. December 14, 2000.
- Kurz, Matt. " Bailey named to Technology Tri-Corridor Committee." October 21, 2003.
- Med.umich.edu: North Campus Research Complex Archived 2009-07-04 at Archive.today.
- Metro Detroit, Michigan score high in biotech VC rankings. Metromode 12-17-2009. Retrieved on July 14, 2010.
- Midwest Health Care Startups Raise $780 M in 2009 Archived 2011-09-10 at the Wayback Machine. BioEnterprise. Retrieved on July 14, 2010.
- Michigan Economic Development Corporation — Life Sciences Corridor.
- University of Michigan Life Sciences.
- Michigan State University — MLSC