Main Street in Louisville, 2008
Location of Louisville, Mississippi
LOUISVILLE MISSISSIPPI Latitude and Longitude:
|• Total||15.3 sq mi (39.6 km2)|
|• Land||15.1 sq mi (39.1 km2)|
|• Water||0.2 sq mi (0.6 km2)|
|Elevation||571 ft (174 m)|
|Population ( 2010)|
|• Estimate (2016) ||6,324|
|• Density||430/sq mi (170/km2)|
|Time zone||UTC-6 ( Central (CST))|
|• Summer ( DST)||UTC-5 (CDT)|
|GNIS feature ID||0693835|
Like Winston County, Louisville is named for Louis Winston (1784–1824), a colonel in the militia, a prominent lawyer, and a judge of the Mississippi Supreme Court. 
On April 28, 2014, Louisville was hit by a EF4 tornado, which killed 10 people.
Louisville is located at  According to the United States Census Bureau, the city has a total area of 15.3 square miles (40 km2), of which 15.1 square miles (39 km2) is land and 0.2 square miles (0.52 km2) (1.44%) is water. It is known by many as the "Front porch of the South". (33.122931, -89.056182).
|U.S. Decennial Census |
As of the census  of 2000, there were 7,006 people, 2,641 households, and 1,817 families residing in the city. The population density was 464.5 people per square mile (179.4/km²). There were 2,884 housing units at an average density of 191.2 per square mile (73.8/km²). The racial makeup of the city was 46.29% White, 52.46% African American, 0.13% Native American, 0.17% Asian, 0.44% from other races, and 0.51% from two or more races. Hispanic or Latino of any race were 1.66% of the population.
There were 2,641 households out of which 34.3% had children under the age of 18 living with them, 40.4% were married couples living together, 25.0% had a female householder with no husband present, and 31.2% were non-families. 28.2% of all households were made up of individuals and 14.4% had someone living alone who was 65 years of age or older. The average household size was 2.55 and the average family size was 3.12.
In the city, the population was spread out with 28.9% under the age of 18, 9.3% from 18 to 24, 24.7% from 25 to 44, 19.8% from 45 to 64, and 17.3% who were 65 years of age or older. The median age was 35 years. For every 100 females, there were 80.6 males. For every 100 females age 18 and over, there were 73.8 males.
The median income for a household in the city was $27,485, and the median income for a family was $31,750. Males had a median income of $29,951 versus $17,491 for females. The per capita income for the city was $15,857. About 24.8% of families and 28.5% of the population were below the poverty line, including 39.3% of those under age 18 and 20.9% of those age 65 or over.
The American Heritage "Big Red" Fire Museum is located in Louisville. This museum features a collection of restored antique fire equipment and fire engines.  The Strand Theatre, in downtown Louisville, is an historic movie theater which now serves as an art and music venue. Louisville native Carl Jackson plays an annual Christmas concert at the theater to raise money for the building's restoration. 
Mississippi Highway 14 enters east from the Alabama state line through Macon and when it enters in Louisville it is also known as Main Street. It leaves westbound eventually traveling to the Mississippi River where it ends.
Mississippi Highway 15 enters from the north from Ackerman, MS, then meets up with Mississippi Highway 25 just north of Louisville. M.S. 25 enters from the north from Starkville. M.S. 15 and 25 travel together along the western side of town. At the southern edge of town they separate: M.S. 15 traveling to Philadelphia & Interstate 20; and M.S. 25 to Jackson.
- Van Chancellor, Basketball Coach
- Thomas D. Clark, Noted Historian
- Doug Cunningham, Former professional football player
- Larry Estes, NFL football player 
- Drew Eubanks, American Basketball Player
- Mark Hudspeth, Football Coach
- Carl Jackson, Country music songwriter
- Andy Kennedy, Basketball Coach, University of Mississippi Rebels
- Coby Miller, Olympic athlete
- Matthew Mitchell, Basketball Coach, University of Kentucky Lady Wildcats
- Lisa Stewart, Country music singer and TV host
- Tyler Pearson, World Champion Steer Wrestler
- Marcus Thames, Major League Baseball player and coach
- "Population and Housing Unit Estimates". Retrieved June 9, 2017.
- "The Hard To Pronounce Town In Every Single State". Retrieved 13 March 2018.
- "Find a County". National Association of Counties. Retrieved 2011-06-07.
- Gannett, Henry (1905). The Origin of Certain Place Names in the United States. Govt. Print. Off. p. 191.
- "US Gazetteer files: 2010, 2000, and 1990". United States Census Bureau. 2011-02-12. Retrieved 2011-04-23.
- "Louisville among top 5 safest cities in MS". 3 September 2014. Retrieved 24 March 2017.
- "Census of Population and Housing". Census.gov. Retrieved June 4, 2015.
- "American FactFinder". United States Census Bureau. Retrieved 2008-01-31.
- The American Heritage "Big Red" Fire Museum in Louisville
- McCain, Joseph (December 13, 2006). "Strong cast of musicians serves up Christmas joy". Winston County Journal. Archived from the original on February 10, 2013.
- "Larry Estes". Retrieved 13 March 2018.