I-65 highlighted in red
|Maintained by ALDOT|
|Length||366.229 mi  (589.388 km)|
|South end||I-10 in Mobile|
|North end||I-65 / US 31 at Tennessee state line|
|Counties||Mobile, Baldwin, Escambia, Conecuh, Butler, Lowndes, Montgomery, Elmore, Autauga, Chilton, Shelby, Jefferson, Blount, Cullman, Morgan, Limestone|
Interstate 65 (I-65) meanders across 366 miles (589 km) of the Alabama countryside linking six of the state's ten largest cities. The highway links together many important roadways that make commerce inside and outside of the state's boundaries possible. It starts at Interstate 10 near Mobile. The route passes through the major cities of Montgomery, Birmingham, and Decatur before entering Tennessee in the north near the town of Ardmore.
I-65 starts in Mobile at an interchange with Interstate 10, not far from the Gulf of Mexico. From there it runs northeast, intersecting with I-165 in Prichard, Alabama and crossing the Mobile River delta at the General W.K. Wilson Jr. Bridge. En route to Montgomery, it passes county seats Evergreen ( Conecuh County) and Greenville ( Butler County). In the case of a hurricane evacuation on Alabama's coast, I-65 can be converted to an evacuation route where all lanes flow in the northbound direction from Mobile to Montgomery. This process is known as contra-flow.
At Montgomery, it intersects the southern terminus of I-85 and crosses the Alabama River north of the city. The Hyundai Corporation's automotive plant in Montgomery is located just off I-65. It can be accessed using the Pintlala-Hope Hull exit (number 164).
At Chilton County, I-65 enters the Birmingham, Alabama, metropolitan area. Approximately halfway between Montgomery and Birmingham, it passes Clanton the county seat, where the water tower, visible from the road, is shaped and painted to resemble a huge peach. Between mile markers 212 and 219, I-65 was designated "War on Terror Memorial Highway" in 2014.
From mile marker 242 to 290 I-65 carries at least 6 lanes of traffic. I-65 intersects I-459 in Hoover, then passes through the cities of Vestavia Hills and Homewood, which often generate heavy traffic. As the interstate passes by downtown Birmingham, south-bound travelers have a view of the Vulcan statue atop Red Mountain. At the north edge of downtown, I-65 intersects I-20/ I-59 with a cross-over interchange, often called " Malfunction Junction".
North of Birmingham at mile 266, interchange ramps provide access to parallel US-31. It is here that I-65 meets the eastern terminus of I-22, which heads northwest to Memphis, Tennessee, filling in a gap in the Interstate system. The interstate then continues 98 miles (158 km) in the general direction of Huntsville, passing the city of Cullman on the way. After entering the Decatur Metropolitan Area, in southern Morgan County, the interstate passes Decatur. The highway connects the Decatur and Huntsville Metropolitan Areas as it crosses Wheeler Lake ( Tennessee River) on a 2.6-mile (4.2 km) bridge. The interstate emerges again into the fringes of Decatur, in an open area of seemingly "endless" cotton fields where it intersects, inside Decatur, with Alabama 20, US-72 Alternate, and the spur-route, I-565 to Huntsville.
Between Walkers Chapel Road in Fultondale and the Tennessee River in Decatur ( Limestone County), I-65 has been designated the "Ronald Reagan Memorial Highway". The sign designating the north end of this portion of road cites Reagan's speech in Decatur on July 4, 1984. The interstate then continues, passing Athens, and merges with US-31. The 2 routes travel concurrently approximately 12 miles to the Tennessee state line.
In the Birmingham/Hoover vicinity, a plan to widen the interstate from North Birmingham to Alabaster has been proposed.[ citation needed] The project is to widen the interstate by adding a HOV lane and keeping the original 3 lanes making it four lanes in each direction. This is planned to stretch to the Pelham area. From there on the interstate will widen from 2 lanes each way to 3 lanes each way into the Helena/Alabaster area.
Near the northern border of Alabama with Tennessee on southbound I-65 is located the Alabama Welcome Center and rest area. The unique feature of this rest area compared to others is the existence of a large Saturn IB rocket erected on the site as a memorial to Alabama's—and in particular, Huntsville's—contribution to NASA's space exploration. 
In 1997, at Georgiana (Exit 114), honoring legendary country musician and Alabama native Hank Williams, the interstate was designated as Hank Williams' Memorial "Lost Highway", after one of his songs. This designation continues northward until mile 179 north of Montgomery. From the state's capital, I-65 doglegs northwards, bypassing Prattville and Clanton before going through Metropolitan Birmingham, Alabama. From exit 242 to 290, this highway carries at least six lanes of traffic. A portion of the interstate running through Birmingham, has been nicknamed "Malfunction Junction" for its numerous wrecks. These accidents include two separate occasions of the support beams melting after crashes by 18-wheelers, and the numerous collisions that happen every year, result from the junction with I-20 and I-59.
In 2004, following the death of President Ronald Reagan, a lengthy segment of I-65 from Jefferson County to Limestone County was designated the Ronald Reagan Memorial Highway. The sign designating the north end of the segment includes a statement from Reagan's speech at Point Mallard Aquatic Center in nearby Decatur on July 4, 1984.
Just a few miles north of I-22 will be the new interchange (exit 274), which will be the Corridor X-1 and has been designated as I-422. This loop route will connect I-65 with I-59 northeast of Birmingham and I-20/I-59 southwest of Birmingham, and this will serve as an Interstate Highway bypass of Birmingham, augmenting the existing I-459, which already provides the southern loop of Birmingham. Construction of this interchange is still several years away, but right-of-way is in the process of being acquired to build I-422.
This section contains a table that is missing mileposts for one or more junctions.
|Mobile||Mobile||0.000||0.000||0||I-10 – Mississippi, Florida||Southbound exit and northbound entrance; southern terminus; I-10 exit 20 tri-stack interchange|
|1.930||3.106||1||US 90 ( SR 16, Government Boulevard)|
|3||Airport Boulevard||Serves Mobile Regional Airport and University of South Alabama|
|5.752||9.257||5B||US 98 ( SR 42, Moffett Road)|
|Prichard||8.412||13.538||8||US 45 ( SR 17, St. Stephens Road) – Prichard, Citronelle|
|9.640||15.514||9||I-165 south – Prichard, Downtown Mobile||I-165 exit 0 northbound; tri-stack interchange.|
|Chickasaw||10||West Lee Street|
|Saraland||13.067||21.029||13||SR 158 (Industrial Parkway) / SR 213 – Eight Mile, Saraland|
|15||Celeste Road – Saraland, Citronelle|
|||19.495||31.374||19||US 43 ( SR 13) – Satsuma, Creola|
|||22||Sailor Road – Creola|
|24.220||38.978||General W.K. Wilson Jr. Bridge|
|Baldwin||||31.793||51.166||31||SR 225 – Stockton, Spanish Fort|
|||33.935||54.613||34||SR 59 – Bay Minette, Stockton|
|||37.724||60.711||37||SR 287 (Gulf Shores Parkway) – Bay Minette, Rabun|
|Escambia||||54||CR 1 (Jack Springs Road)|
|||57.656||92.788||57||SR 21 – Atmore, Uriah|
|Barnett Crossroads||69.356||111.618||69||SR 113 – Flomaton, Wallace|
|Conecuh||||77.402||124.566||77||SR 41 – Brewton, Repton|
|||83||CR 7 – Castleberry, Lenox|
|||92.930||149.556||93||US 84 ( SR 12) – Evergreen, Monroeville|
|||96.509||155.316||96||SR 83 – Evergreen, Midway|
|||100.685||162.037||101||CR 29 – Owassa|
|Butler||||107||Hank Williams Road – Grace, Garland|
|||113.969||183.415||114||SR 106 – Georgiana, Starlington|
|Greenville||127.661||205.450||128||SR 10 (Pineapple Highway) – Greenville, Pine Apple||Southern end of SR 10 Truck overlap|
SR 185 / SR 10 Truck east – Greenville
|Northern end of SR 10 Truck overlap|
|Lowndes||||141.531||227.772||142||SR 185 – Fort Deposit, Logan|
|||151.108||243.185||151||SR 97 – Letohatchee, Davenport|
|||158||To US 31 ( SR 3, Tyson Road) – Pintlala, Tyson|
|Montgomery||||163.792||263.598||164||US 31 ( SR 3) – Pintlala, Hope Hull|
|Montgomery||166||I-85 north to I-685||Future southern terminus of Montgomery bypass; future southern terminus of I-85|
|167.103||268.926||167||US 80 west ( SR 8 west) – Selma||Southern end of US 80/SR 8 overlap|
|168.213||270.713||168||US 80 east / US 82 east ( SR 6 east/ SR 8 east/ SR 21, South Boulevard) to US 231 ( SR 53) / US 331 ( SR 9)||Northern end of US 80/SR 8 overlap; southern end of US 82/SR 6 overlap|
|169||Edgemont Avenue||Southbound exit and northbound entrance|
|171.157||275.450||171||I-85 / I-685 north / Day Street – Atlanta||I-85 no number signed; future I-685, exit 0|
|172||Herron Street, Clay Street – Downtown Montgomery|
|Bridge over the Alabama River|
|172.725||277.974||173||To US 231 (North Boulevard)||Unsigned SR 152|
|Elmore||Millbrook||176||SR 143 – Millbrook, Coosada||Northbound exit and southbound entrance|
|178.961||288.010||179||US 82 west ( SR 6 west, Cobbs Ford Road) / SR 14 west to Montgomery Toll Road – Millbrook, Prattville||Northern end of US 82/SR 6 overlap; southern end of SR 14 overlap|
|Prattville||181.282||291.745||181||SR 14 east – Prattville, Wetumpka||Northern end of SR 14 overlap|
|Autauga||186.426||300.024||186||US 31 ( SR 3) – Pine Level, Prattville|
|Clanton||205.340||330.463||205||US 31 / SR 3 ( SR 3) / SR 22 – Clanton, Verbena|
|208||Lake Mitchell Road – Clanton, Lake Mitchell|
|211.876||340.981||212||SR 145 (Lay Dam Road) – Clanton, Lay Dam||Peach Tower exit|
|Shelby||Calera||228.380||367.542||228||SR 25 (Main Street) – Montevallo, Calera|
|231.206||372.090||231||US 31 ( SR 3) / SR 3 – Saginaw, Calera, Montevallo|
|234||Shelby County Airport|
|||238.321||383.540||238||US 31 ( SR 3, 1st Street) – Alabaster, Saginaw|
|Pelham||242||CR 52 – Pelham, Helena|
|246.062||395.998||246||SR 119 (Cahaba Valley Road)|
|Hoover||247||CR 17 (Valleydale Road)|
|Jefferson||250.083||402.470||250||I-459 – Atlanta, Gadsden, Tuscaloosa||I-459 exit 15|
|||251.967||405.502||252||US 31 (Montgomery Highway) / SR 3|
|256||Oxmoor Road – Homewood||Signed as exits 256A (west) and 256B (east) southbound|
|Birmingham||258||Green Springs Avenue|
|259A||University Boulevard (northbound)|
6th Avenue South (southbound)
|Signed as exit 259 northbound|
|259B||4th Avenue South & 3rd Avenue South||Southbound exit (4th Avenue) and northbound entrance (3rd Avenue)|
|260||US 11 ( US 78/ SR 4 east/ SR 7, 3rd Avenue North) / 6th Avenue North – Downtown Birmingham||Signed as exit 260B northbound|
|260.562||419.334||261||I-20 ( SR 4 west) / I-59 / US 78 / SR 4 – Gadsden, Atlanta, Tuscaloosa||Southern end of SR 4/US 78 overlaps; signed as exits 261B (east/north) and 261C (west/south); I-20/59 exits 124B-C|
|262A||16th Street||Northbound exit and southbound entrance|
|263||32nd Avenue (northbound) |
33rd Avenue (southbound)
|264||Daniel Payne Drive/Lewisburg Road||Ramp to I-65 north also connects to I-22 west|
|Fultondale||264.010||424.883||265A||I-22 / US 78 / SR 4 – Memphis||Northern end of SR 4/US 78 overlaps; eastern terminus of I-22, exit 95|
|265B||US 31 ( SR 3) – Fultondale|
|267||Walker Chapel Road|
|272||Mt. Olive Road|
|||275||To US 31 ( SR 3, Barber Road) – Morris|
|Warrior||280||To US 31 ( SR 3, Service Road) – Warrior|
|281||Old US 31 – Warrior|
|282||Cane Creek Road – Robbins, Warrior|
|Blount||Smoke Rise||284.361||457.635||284||US 31 south ( SR 3 south) / SR 160 east – Hayden, Corner||Southern end of US 31/SR 3 overlap|
|287.370||462.477||287||US 31 north ( SR 3 north, Bee Line Highway) – Garden City, Blount Springs||Northern end of US 31/SR 3 overlap|
|||289||Empire, Blount Springs|
|Cullman||||291.861||469.705||291||SR 91 – Hanceville, Colony|
|||299.446||481.912||299||SR 69 south – Jasper, Dodge City||Southern end of SR 69 overlap|
|||303.490||488.420||304||SR 69 north – Cullman, Good Hope||Northern end of SR 69 overlap|
|Good Hope||305||CR 222 (Good Hope Road)|
|Cullman||307.464||494.815||308||US 278 ( SR 74) – Cullman, Double Springs|
|310.039||498.959||310||SR 157 (Section Line Road) – Cullman, Moulton|
|Morgan||||318.161||512.030||318||US 31 ( SR 3, 2nd Avenue) – Lacon, Vinemont|
|||321.855||517.975||322||Pike Road – Falkville, Eva|
|327.474||527.018||328||SR 36 (Main Street) – Hartselle|
|333.337||536.454||334||SR 67 – Decatur, Priceville, Somerville|
|336.619||541.736||Bridge over Wheeler Lake and Tennessee River|
|Limestone||Huntsville||340.002||547.180||340||I-565 east / SR 20 west ( US 72 Alt.) – Huntsville, Decatur||Signed as exits 340A (west) and 340B (east) southbound; I-565 exit 1 westbound & 1A-B eastbound; eastern terminus of SR 20; western terminus of I-565|
|Tanner||347.412||559.105||347||Huntsville–Browns Ferry Road|
|Athens||351.024||564.918||351||US 72 ( SR 2) – Athens, Huntsville|
|354.157||569.960||354||US 31 south – Athens||Southern end of US 31 overlap; unsigned northern terminus of SR 3|
|||364.826||587.131||365||SR 53 south (Upper Elkton Road, 7th Street) – Ardmore||Northern terminus of SR 53|
|||366.229||589.388||I-65 / US 31 north – Nashville||Continuation into Tennessee|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
- Total Mileage in Alabama-366.00 miles
- From Interstate 10 Exit 0 to Exit 13 ( Saraland) (3-4 lanes each way, 4th lane exit only)
- From Exit 13 to Exit 167 U.S. Highway 80 west ( Selma) (2 lanes each way)
- From Exit 167 to Exit 181 ( Prattville)/( Wetumpka) (3 lanes each way)
- From Exit 181 to Exit 242 County Road 52 ( Pelham) (2 lanes each way)
- From Exit 242 to Exit 261 Interstate 20/ Interstate 59 (3-4 lanes each way, 5 lanes at Malfunction Junction)
- From Exit 261 to Exit 267 Walker Chapel Road ( Fultondale) (4 lanes each way)
- From Exit 267 to Blount County/ Cullman County line Mile marker 291 (3 lanes each way)
- From Mile marker 291 to Tennessee state line (2 lanes each way)
- "FHWA Route Log and Finder List: Table 1". Federal Highway Administration. Retrieved 4 October 2014.
- "Heroes Highway of Alabama". Montgomerygop.net. Retrieved 2009-08-05.
- Simon, Scott (July 23, 2005). "Alabama Billboard's Message Changes". All Things Considered. NPR. Archived from the original on 2007-07-14. Retrieved July 26, 2013.
- Hughes, Bayne (April 6, 2014). "Iconic rocket due for repair". Decatur Daily. Retrieved April 8, 2014.
- "Milepost/General Highway Maps". Alabama Department of Transportation. Archived from the original on April 2, 2015. Retrieved April 14, 2016.
- Media related to Interstate 65 in Alabama at Wikimedia Commons