I- highlighted in red
|Maintained by KYTC|
|Length||191 mi  (307 km)|
|West end||I-64 / US 150 at Indiana state line|
I-65 / I-71 in Louisville
I-264 in Louisville
I-265 / KY 841 in Middletown
I-75 in Lexington
|East end||I‑64 at West Virginia state line|
|Counties||Jefferson, Shelby, Franklin, Woodford, Scott, Fayette, Clark, Montgomery, Bath, Rowan, Carter, Boyd|
In the U.S. state of Kentucky, Interstate 64 travels for 191 miles (307 km) passing by the major towns and cities of Louisville, Frankfort, Lexington and Ashland. It has several major junctions within the state: Interstate 65, Interstate 71, Interstate 264 and Interstate 265 in Louisville, and Interstate 75 in Lexington.
The interstate is host to two "exceptionally significant" structures indicated by the Federal Highway Administration. One is the Cochran Hill Tunnel,  a twin tube at Cherokee Park in Louisville built in 1974,  and the other is a 1960s-era modern-styled rest area near Winchester. 
Between the Indiana state line and Lexington, the interstate is named the Daniel Boone Expressway.
The Cochran Hill Tunnel in Louisville, also known as the Cherokee Park Tunnel, underwent restoration in 2001, which involved the reconstruction of the concrete pavement, the installation of new tiles and improvements to lighting. Efforts were made to paint the interior tiles of the tunnel with a mural, but were dropped because opponents stated that drivers would become distracted while passing through the tunnel, driving and viewing the art work at the same time.   The tunnels, which opened in 1974, are one of three sites in Kentucky deemed "exceptionally significant" by the Federal Highway Administration. The designation meant that it will be very difficult for the stretch of interstate running through Cherokee Park ever to be widened. 
Construction began on a Kentucky Route 180 interchange improvement project in the summer of 2006.   The $34 million project entailed the rebuilding of six bridges, the widening of Kentucky Route 180 to four-lanes in the vicinity of the interchange and the conversion of the ramps into a diamond. The project was finished in the fall of 2008.
In March 2007, Governor Ernie Fletcher signed Senate Bill 83 which allowed for an increase in speed limits on rural interstates and parkways. Speed limits on rural sections of Interstate 64 were increased from 65 MPH to 70 mph (110 km/h), following an engineering study by the Kentucky Transportation Cabinet. New signage was installed in July 
On June 7, 2007, Interstate 64 between the junction of Interstate 264 and Interstate 65 and Interstate 71 in downtown Louisville was closed to through traffic.  The section of highway featured three-lanes of traffic in each direction on an elevated viaduct paralleling the Ohio River, carrying 90,000 vehicles-per-day. The closure was part of a $50 million refurbishment project that involved replacing 132 expansion joints and repaving more than four-miles (6 km) of interstate and interchanges.  The work was completed in two phases, starting with the entire project area being closed on three weekends in June, followed by a section of highway closed from 3rd to 22nd Streets in early July to early August. However, the Interstate was not finished because of the section between Frankfort and Lexington. The state could not attain the right of way here because of very famous horse parks northwest of Lexington. After a couple of tries to get the right of way, the state was able to get the right of way and began construction on this segment. It was the last segment of Interstate 64 to be completed in Kentucky.
Controversially, I-64 runs through Louisville Waterfront Park, a key part of the revitalization of Downtown Louisville, and portions of the park exist under it. 8664.org, a grassroots campaign with popular support but little apparent political momentum, aimed to re-route and remove I-64 to enhance Louisville's waterfront. I-64 through Louisville would be re-signed as I-364.[ citation needed] I-64 was to be widened over the park as a part of the Ohio River Bridges Project. But plans to widen the freeway over the park have been abandoned to reduce costs of the Ohio River Bridges Project. 
|County||Location ||mi ||km||Exit||Destinations||Notes|
Sherman Minton Bridge|
I-64 west / US 150 west; continuation into Indiana
|Jefferson||Louisville||0.9||1.4||1||I-264 east – Shively||Western terminus of I-264, exits 0A-B westbound; tri-stack interchange|
|2.7||4.3||3||US 150 east (22nd Street)||Eastern terminus of concurrency with US 150|
|3.9||6.3||4||9th Street / Roy Wilkins Avenue – Downtown|
|4.5||7.2||5B||3rd Street / River Road – Downtown||Westbound exit and eastbound entrance|
|5.2||8.4||5A||I-65 – Nashville, Indianapolis||Signed as exit 5A (south) and 5B (north) eastbound; eastbound exit to I-65 north closed until 2017|
|5.9||9.5||6||I-71 north – Cincinnati||Eastbound access only; I-71 exit 1B northbound to I-64 eastbound, 1A southbound to 64 westbound; southern terminus of I-71|
|6.4||10.3||7||US 42 / US 60 (Mellwood Avenue / Story Avenue)|
|7.8||12.6||8||Grinstead Drive||Access to Lexington Road (US 60 Alt) to Southern and Louisville Seminaries|
|8.1||13.0||Cochran Hill Tunnel|
|12.3||19.8||12||I-264 (Watterson Expressway) – Louisville International Airport||Signed as exits 12A (west) and 12B (east) eastbound; I-264 exits 19A-B|
|14.9||24.0||15||KY 1747 (Hurstbourne Parkway) – Jeffersontown, Middletown, Industrial Park||signed as exits 15A (south), 15B (south-local access), and 15C (north) eastbound|
|Jeffersontown||17.1||27.5||17||Blankenbaker Parkway ( KY 913)||No signage for KY 913|
|18.9||30.4||19||I-265 (Gene Snyder Freeway) / KY 841||Signed as exits 19A (south) and 19B (north); I-265 exits 25A-B|
|Shelby||Simpsonville||27.5||44.3||28||KY 1848 (Buck Creek Road) – Simpsonville|
|Shelbyville||31.8||51.2||32||KY 55 (Taylorsville Road) – Taylorsville, Shelbyville|
|35.1||56.5||35||KY 53 (Mt Eden Road) – Shelbyville|
|||43.3||69.7||43||KY 395 (Waddy Road) – Waddy, Peytona|
|Franklin||Frankfort||47.7||76.8||48||KY 151 to US 127 south – Lawrenceburg, Graefenburg|
|48.8||78.5||49||US 460 east – Frankfort|
|53.0||85.3||53||US 127 – Lawrenceburg, Frankfort||Signed as exit 53A (south) and 53B (north)|
|57.8||93.0||58||US 60 – Versailles, Frankfort|
|Woodford||Midway||65.2||104.9||65||KY 341 to US 62 west – Versailles, Midway|
|Scott||||68.8||110.7||69||US 62 east (Paynes Depot Road) – Georgetown||Ramps provide access to both eastbound and westbound US 62|
|Fayette||Lexington||74.7||120.2||75||I-75 north – Georgetown, Cincinnati||Western terminus of concurrency with I-75, exit 118 southbound, uses I-75 exit numbers and mile markers.|
|76.9||123.8||115||KY 922 (Newtown Pike) to Bluegrass Parkway – Lexington, Blue Grass Airport|
|79.2||127.5||113||US 27 / US 68 (Broadway) – Lexington, Paris|
|81.3||130.8||81||I-75 south – Richmond, Knoxville||Eastern terminus of concurrency with I-75, exit 111 northbound.|
|87.3||140.5||87||KY 859 - Bluegrass Station|
|Clark||Winchester||94.0||151.3||94||KY 1958 to KY 627 / Van Meter Road – Winchester|
|96.1||154.7||96||KY 627 – Winchester, Paris||Signed as exits 96A (south) and 96B (north) westbound|
|||97.5||156.9||98||Mountain Parkway east – Prestonsburg, Campton||Eastbound exit and westbound entrance; westbound exit is via a U-turn at exit 96|
|||101.6||163.5||101||US 60 – Winchester, Mount Sterling|
|Montgomery||Mount Sterling||109.6||176.4||110||US 460 / KY 11 – Flemingsburg, Mount Sterling, Paris|
|112.3||180.7||113||US 60 – Mount Sterling, Owingsville|
|Bath||Owingsville||121.1||194.9||121||KY 36 – Owingsville, Frenchburg|
|122.9||197.8||123||US 60 – Owingsville, Salt Lick|
|Rowan||||132.8||213.7||133||KY 801 – Sharkey, Farmers|
|Morehead||137.1||220.6||137||KY 32 east / Flemingsburg Road – Flemingsburg, Morehead|
|Carter||||156.0||251.1||156||KY 2 to KY 59 – Olive Hill, Vanceburg|
|Olive Hill||161.3||259.6||161||US 60 – Olive Hill, Grayson|
|Grayson||171.4||275.8||172||KY 1 / KY 7 to KY 9 (AA Hwy.) – Maysville, Grayson|
|||178.3||286.9||179||KY 67 north (Industrial Parkway) – Greenup, Wurtland|
|Boyd||Coalton||181.2||291.6||181||US 60 – Grayson, Ashland|
|Ashland||185.2||298.1||185||KY 180 to US 60 – Cannonsburg, Ashland|
|||190.5||306.6||191||US 23 – Ashland, Louisa|
|||191.0||307.4||I‑64 east – Huntington||Continuation into West Virginia|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
- Interstate 264
|Location||Louisville– Glenview Manor|
Interstate 264 is an inner loop route in Metro Louisville. Signed as the Georgia Davis Powers Shawnee Expressway between its western terminus at I-64 in Shawnee and US 31W/ US 60 ( Dixie Highway) in Shively, and as the Watterson Expressway from US 31W/US 60 to its northeastern terminus at I-71 in Glenview Manor. Along the way, it provides access to Louisville International Airport at its junction with I-65.
- Interstate 464
Interstate 464 was proposed as current Kentucky Route 4. 3/4 of the entire route was built, but the missing sections were North and East of Lexington where I-464 would run to I-64/I-75, then run concurrent with I-64/I-75 southeast to meet up with its eastern section. It is currently signed as KY 4, but more commonly known as New Circle Road.
- Federal Highway Administration (October 31, 2002). "FHWA Route Log and Finder List: Table 1". Retrieved February 24, 2009.
- "Final List of Nationally and Exceptionally Significant Features of the Federal Interstate Highway System" (PDF). Federal Highway Administration. November 1, 2006. Retrieved September 13, 2011.
- Elson, Martha (January 17, 2007). "Tunnel could stop wider I-64". The Courier-Journal. Archived from the original on April 8, 2013.
- "Interviews for tunnel artist set to begin". The Courier-Journal. February 5, 2001.[ dead link]
- "Tunnel mural proposal drawing criticism". The Independent (Ashland). February 5, 2001.
- Hart, Kenneth (January 1, 2007). "Road Work Ahead". The Independent (Ashland). Retrieved January 2, 2007.
- "I-64 improvement project under way in Boyd". The Independent (Ashland). October 5, 2007. Retrieved October 10, 2007.
- "New speed limit signs erected". The Independent (Ashland). January 4, 2007.
- Tabor, Britney (June 8, 2007). "I-64 shutdown starts without major problems". The Courier-Journal. Retrieved June 9, 2007.[ dead link]
- Shafer, Sheldon (March 11, 2007). "Big I-64 headache coming". The Courier-Journal.[ dead link]
- "Study says cost-cutting measures could reduce Ohio River Bridges". WDRB. June 2, 2011. Retrieved October 4, 2014.|
- U.S. Census Bureau. "2009 Boundary and Annexation Survey Maps". Retrieved June 4, 2009.[ dead link]
- Google (2 August 2014). "Overview map of Interstate 64 in Kentucky" (Map). Google Maps. Google. Retrieved 2 August 2014.