I-59 highlighted in red
|Length||445.23 mi  (716.53 km)|
|South end||I-10 / I-12 in Slidell, LA|
|North end||I-24 in Wildwood, GA|
|States||Louisiana, Mississippi, Alabama, Georgia|
Interstate 59 (I-59) is an Interstate Highway located in the southeastern United States. It is a north–south route that spans 445.23 miles (716.53 km) from a junction with I-10 and I-12 at Slidell, Louisiana to a junction with I-24 near Wildwood, Georgia.
The highway connects the metropolitan areas of New Orleans, Louisiana and Chattanooga, Tennessee, running closely parallel to the older U.S. Route 11 (US 11) corridor for the entire distance. Approximately one-third of the route, spanning 153 miles (246 km) from Meridian, Mississippi to Birmingham, Alabama, overlaps that of the east–west I-20.
I-59 spans 11.48 miles (18.48 km) in Louisiana, the shortest distance in the four states through which it travels. The route begins at a partial cloverleaf interchange with I-10 (exit 267) and I-12 (exit 85) at the northeast corner of Slidell, a city in St. Tammany Parish. From this interchange, connections are made to New Orleans and Hammond, as well as Bay St. Louis, Mississippi. Heading north, I-59 has two exits serving the town of Pearl River, where it begins a concurrency with US 11. Immediately afterward, the highway crosses the West Pearl River and passes through an interchange with Old US 11, a portion of the pre-interstate alignment serving the Pearl River Wildlife Management Area. I-59 then travels through the Honey Island Swamp for 6 miles (9.7 km) before crossing the main branch of the Pearl River into Mississippi.   
In Mississippi, I-59 continues to run parallel with US 11, traversing mainly rural areas, but going through or bypassing the towns of Picayune, Poplarville, Hattiesburg, Ellisville, Moselle, Laurel, and Meridian.
For its length in Mississippi, I-59 either travels concurrent with, or runs close to, US 11. Between the towns of Pearl River and Picayune, US 11 travels concurrent with I-59. The highway also has concurrencies with US 98 in Hattiesburg; Mississippi Highway 42 (MS 42) just north of Hattiesburg; US 84 and Mississippi Highway 15 (MS 15) in Laurel, and US 80, US 11, and MS 19 in the Meridian area.
A notoriously sharp S-curve, at milepost 96 in Laurel, was the subject of a large reconstruction project. Those sharp curves were the legacy of an overpass over the Southern Railway on a town bypass with design dating from before the Interstate Highways, and they featured a 40 mph (65 km/h) speed limit, one of the lowest anywhere on the Interstate Highway System. This work was completed in 2009.
Just west of Meridian, I-20 joins I-59 and these two highways continue together for 145 miles (233 km), across the border with Alabama to and through Birmingham. The exit numbers are given as those of I-59.
At 4:00 p.m. on August 27, 2005, for the first time in its history, the southbound lanes of I-59 were temporarily redirected northward to accommodate evacuation for Hurricane Katrina. This was a previously agreed to joint plan by the states of Mississippi and Louisiana called contraflow lane reversal. The program began at the Louisiana–Mississippi state line and continued 21 miles (34 km) north to Poplarville.
I-59 and I-20 travel together for about 40 percent of their route through Alabama, passing northeast through Tuscaloosa before finally parting ways in eastern Birmingham.
In Birmingham, many wrecks and accidents occur near the cross-over interchange of I-20/I-59 and I-65(commonly called "Malfunction Junction"). On two occasions, 18-wheelers crashed and burned fiercely enough to melt the support beams of overpasses. Beginning in eastern Birmingham, I-59 continues on its own northeast, passing by Gadsden and Fort Payne in the foothills of the Appalachian Mountains, before entering Georgia.
I-59 from Gadsden at mile marker 182 to Stephen's Gap at mile marker 193 had degraded over the decades since it was opened into a rough concrete highway. Between 2010 and 2014, a construction project called "Project 59" took place between Gadsden and Fort Payne. This project consisted of reconstructing the Interstate Highway with unbonded concrete (without any space cracks) as well as modifications to the width and vertical clearance of the bridges and overpasses in the segment.
I-59 has a short trek through Georgia, with only three exits before ending at I-24 several miles west of Chattanooga, Tennessee, in Wildwood, Georgia. Within Georgia it carries unsigned designated as State Route 406 (SR 406) for internal Georgia Department of Transportation (GDOT) purposes. 
This section contains a table that is missing mileposts for one or more junctions.
|State||Parish/County||Location||mi   ||km||Exit||Destinations||Notes|
Bay St. Louis|
I-12 west – Hammond
|Southern terminus of I-59; eastern terminus of I-12; signed as exits 1A (I-12 west), 1B (I-10 east), and 1C (I-10 west)|
|3||US 11 south / LA 1090 south – Pearl River||Southern end of US 11 concurrency; northern terminus of LA 1090|
|5A||LA 3081 – Pearl River||Northern terminus of LA 3081|
|5B||Honey Island Swamp||To Old US 11|
|11||Pearl River Turnaround|
|Louisiana–Mississippi state line|
|Mississippi||Pearl River||||0.5||0.80||1||US 11 north / MS 607 south – Nicholson, NASA John C. Stennis Space Center||North end of US 11 concurrency|
|Picayune||4.0||6.4||4||MS 43 south – Picayune, Kiln||South end of MS 43 concurrency|
|6.0||9.7||6||MS 43 north – North Picayune||North end of MS 43 concurrency|
|||26.7||43.0||27||MS 53 – Necaise, Poplarville|
|||29.6||47.6||29||MS 26 – Poplarville, Wiggins|
|Lumberton||41.1||66.1||41||MS 13 – Lumberton|
|Lamar||Purvis||51.3||82.6||51||MS 589 – Purvis|
|Forrest||||58.6||94.3||59||US 98 east – Lucedale, Mobile||South end of US 98 concurrency|
|||60.5||97.4||60||US 11 – South Hattiesburg, Downtown Hattiesburg|
|Lamar||Hattiesburg||64.8||104.3||65||US 98 west ( MS 198 east) / Hardy Street – Columbia||North end of US 98 concurrency; signed as exits 65A (MS 198) and 65B (US 98) northbound|
|Forrest||67.4||108.5||67||US 49 / MS 42 west – Hattiesburg, Jackson||South end of MS 42 concurrency; signed as exits 67A (south) and 67B (north)|
|69.6||112.0||69||MS 42 east (Evelyn Gandy Parkway) – Petal||North end of MS 42 concurrency|
|Jones||||75.6||121.7||76||Hattiesburg-Laurel Regional Airport|
|||85.6||137.8||85||MS 590 – Ellisville|
|Ellisville||88.2||141.9||88||MS 29 / MS 588 – Ellisville|
|||90.3||145.3||90||US 11 (Ellisville Boulevard)|
|Laurel||92.9||149.5||93||US 11 – South Laurel|
|94.5||152.1||95||US 84 west / MS 15 north (16th Avenue)||South end of US 84/MS 15 concurrency; signed as exits 95A (south) and 95B (north)|
|95.0||152.9||95C||Beacon Street||Laurel S-curve southbound|
|95.6||153.9||96A||4th Avenue, Masonite Road|
|96.0||154.5||96B||MS 15 south (Cook Avenue) – Richton||North end of MS 15 concurrency|
|96.8||155.8||97||US 84 east (Chantilly Street) – Waynesboro||North end of US 84 concurrency|
|Jasper||||113.3||182.3||113||MS 528 – Heidelberg, Bay Springs|
|Clarke||||125.9||202.6||126||MS 18 – Rose Hill, Pachuta|
|||133.6||215.0||134||MS 513 – South Enterprise, Rose Hill||Rose Hill not on northbound sign|
|||147.9||238.0||149||I-20 west / US 80 west – Jackson||South end of I-20/US 80 concurrency|
|Meridian||149.9||241.2||150||US 11 south / MS 19 north – Philadelphia, Meridian Airport||South end of US 11/MS 19 concurrency|
|150.5||242.2||151||Valley Road, 49th Avenue|
|152.8||245.9||153||MS 145 south (22nd Avenue) – Quitman|
|153.7||247.4||154||US 11 north / US 80 east / MS 19 south / MS 39 north – De Kalb, Butler||North end of US 11/US 80/MS 19 concurrency; signed as exits 154A (south) and 154B (north) northbound|
|155.4||250.1||156||Jimmie Rodgers Pkwy|
|156.5||251.9||157||US 45 – Quitman, Macon||Signed as exits 157A (south) and 157B (north)|
|||168.2||270.7||169||US 11 / US 80 – Kewanee|
|Mississippi–Alabama state line|
|Alabama||Sumter||||0.804||1.294||1||To US 80 east – Cuba, Demopolis|
|||8.041||12.941||8||SR 17 – York|
|||17.059||27.454||17||SR 28 – Livingston, Boyd|
|||23.141||37.242||23||CR 20 – Gainesville, Epes|
|||40.766||65.607||40||SR 14 – Aliceville, Eutaw|
|||52.244||84.079||52||US 11 / US 43 – Knoxville|
|Tuscaloosa||||62.466||100.529||62||SR 300 – Fosters||SR 300 is an unsigned route|
|Tuscaloosa||68.083||109.569||68||Northport Tuscaloosa Western Bypass|
|71.367||114.854||71||I-359 north / SR 69 – Tuscaloosa, Moundville||Signed as exits 71A (south) and 71B (north); unsigned US 11|
|73.003||117.487||73||US 82 (McFarland Boulevard)|
|75.961||122.247||76||US 11 (Skyland Boulevard)|
|||79.895||128.579||79||US 11 – Tuscaloosa, Coaling|
|||97.138||156.328||97||US 11 south / SR 5 south – West Blocton, Centreville||South end of US 11/SR 5 concurrency|
|||100.292||161.404||100||Abernant, Bucksville||Unsigned eastern terminus for SR 216|
|Jefferson||||104.159||167.628||104||Rock Mountain Lake||McAshan Drive|
|||106.201||170.914||106||I-459 north – Gadsden, Montgomery, Atlanta||Southern terminus of I-459|
|Bessemer||108.396||174.446||108||US 11 north / SR 5 north (Academy Drive)||North end of US 11/SR 5 concurrency|
|110.021||177.062||110||Splash Adventure Parkway|
|112.341||180.795||112||18th Street, 19th Street|
|115.520||185.911||115||Allison–Bonnet Memorial Drive, Jaybird Road|
|Fairfield||118.304||190.392||118||Valley Road – Fairfield|
|Birmingham||119.025||191.552||119||Lloyd Noland Parkway||Signed as exit 119A southbound|
|119.727||192.682||119B||Avenue I||Southbound exit and northbound entrance|
|120.934||194.624||120||SR 269 (20th Street) / Ensley Avenue||Southern terminus of SR 269|
|121.238||195.114||121||Bush Boulevard||Southbound exit and northbound entrance|
|123.374||198.551||123||US 78 (Arkadelphia Road) – Jasper||Unsigned SR 5|
|124.740||200.750||124||I-65 – Montgomery, Huntsville||Signed as exits 124A (south) and 124B (north)|
|125.221||201.524||125A||17th Street – Downtown Birmingham||Exit ramp closed May 31, 2017 through 2018 for reconstruction; southbound entrance|
|125.639||202.196||125B||22nd Street – Downtown Birmingham||Signed as exit 125 southbound|
|126.239||203.162||126A||US 31 / US 280 east / Carraway Boulevard – Civic Center||Western terminus of US 280|
|126.825||204.105||126B||31st Street North|
|128.257||206.410||128||SR 79 (Tallapoosa Street)|
|130.301||209.699||130||I-20 east – Atlanta||North end of I-20 concurrency|
|131.801||212.113||131||Oporto–Madrid Boulevard||Northbound exit and southbound entrance|
|132.214||212.778||132||US 11 (1st Avenue North)||No access from I-59 north to US 11 south, from US 11 south to I-59 north, or from US 11 north to I-59 south|
|133.814||215.353||133||4th Avenue South||Northbound exit and southbound entrance|
|134.383||216.268||134||To SR 75 (Roebuck Parkway) – Center Point|
|Trussville||137.202||220.805||137||I-459 south – Montgomery, Tuscaloosa, Atlanta||Northern terminus of I-459|
|||143.647||231.177||143||Deerfoot Parkway, Mount Olive Church Road|
|||147||I-422 south||Proposed interchange|
|||147.647||237.615||148||To US 11 – Argo|
|Saint Clair||||153.911||247.696||154||SR 174 – Odenville, Springville|
|||156.178||251.344||156||SR 23 – Springville, Ashville, St Clair Springs|
|||166.322||267.669||166||US 231 – Ashville, Oneonta|
|Etowah||Attalla||181.294||291.764||181||SR 77 – Attalla, Rainbow City|
|Attalla||182.058||292.994||182||I-759 east – Gadsden||Western terminus of I-759|
|183.030||294.558||183||US 278 (SR-74) / US 431 (SR-1/5th Avenue) – Attalla, Gadsden|
|Gadsden||188.082||302.689||188||SR 211 to US 11 – Noccalula Falls Park|
|DeKalb||||205.148||330.154||205||SR 68 – Collinsville, Crossville|
|||218.654||351.890||218||SR 35 – Fort Payne, Rainsville|
|||222.152||357.519||222||US 11 – Fort Payne|
|||231.419||372.433||231||SR 40 / SR 117 – Valley Head, Hammondville|
|||239.642||385.666||239||To US 11 / Sulphur Springs Road|
|Alabama–Georgia state line|
|Georgia||Dade||||4.1||6.6||4||Rising Fawn||Old exit 1|
|Trenton||11.5||18.5||11||SR 136 – Trenton||Old exit 2|
|||17.3||27.8||17||Slygo Road – New England||Old exit 3|
|||19.5||31.4||—||I-24 ( SR 409) – Nashville, Chattanooga||Northbound exit and southbound entrance|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
- "FHWA Route Log and Finder List / Table 1: Main Routes of the Dwight D. Eisenhower National System Of Interstate and Defense Highways as of December 31, 2016". Federal Highway Administration. February 22, 2017. Retrieved May 14, 2017.
- Google (May 14, 2017). "Overview Map of I-59 in Louisiana" (Map). Google Maps. Google. Retrieved May 14, 2017.
- Louisiana Department of Transportation and Development Office of Multimodal Planning (February 2012). St. Tammany Parish (East Section) (PDF) (Map). Louisiana Department of Transportation and Development. Retrieved May 14, 2017.
- Louisiana Department of Transportation and Development Office of Multimodal Planning (February 2012). District 62: Official Control Section Map / Construction and Maintenance (PDF) (Map). Louisiana Department of Transportation and Development. Retrieved May 14, 2017.
- Office of Transportation Data (2003). "Interstate Mileage Report (438 Report)" (PDF). Georgia Department of Transportation. Archived from the original (PDF) on 2006-02-18.
- "La DOTD GIS Data". Louisiana Department of Transportation and Development. September 2015. Retrieved May 14, 2017.
- . October 27, 2016
https://aldotgis.dot.state.al.us/milepostmaps/default.htm. Missing or empty
- "Overview Map of Interstate 59 in Georgia". Google Maps. Retrieved September 12, 2016.
- Media related to Interstate 59 at Wikimedia Commons