The U.S. Office of Management and Budget designates the area as the Gainesville, Florida Metropolitan Statistical Area, a metropolitan statistical area used for statistical purposes by the United States Census Bureau and other government agencies. The OMB defines the MSA as comprising Alachua and Gilchrist Counties, with Gainesville as its principal city. The Gainesville, Florida Standard Metropolitan Statistical Area was first defined in 1971, consisting of only Alachua County. In 1983 Bradford County was added to the MSA. Bradford County was removed from the MSA in 1993. In 2003 Gilchrist County was added to the MSA.
As of the census  of 2000, there were 232,392 people, 92,530 households, and 51,494 families residing within the MSA. The racial makeup of the MSA was 74.53% White, 18.53% African American, 0.25% Native American, 3.33% Asian, 0.03% Pacific Islander, 1.35% from other races, and 1.98% from two or more races. Hispanic or Latino of any race were 5.55% of the population.
The median income for a household in the MSA was $30,877, and the median income for a family was $40,536. Males had a median income of $29,665 versus $24,003 for females. The per capita income for the MSA was $16,225.
- "Annual Estimates of the Population of Metropolitan and Micropolitan Statistical Areas: April 1, 2000 to July 1, 2007 (CBSA-EST2007-01)". 2007 Population Estimates. United States Census Bureau, Population Division. March 27, 2008. Archived from the original ( CSV) on September 5, 2008. Retrieved August 18, 2008.
- "American FactFinder". United States Census Bureau. Archived from the original on September 11, 2013. Retrieved 2008-01-31.