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Louisville, Kentucky, today is home to dozens of companies and organizations across several industrial classifications. However, the underpinning of the economy of Louisville since it earliest days has been the shipping and cargo industries.
- 1 Shipping and logistics
- 2 Health care and medical sciences
- 3 Product manufacturing: Automotive, home appliances, bourbon and more
- 4 High tech
- 5 Independent businesses
- 6 Other industries
- 7 Historical businesses
- 8 Notable companies, company divisions and organizations based in Louisville
- 9 See also
- 10 References
- 11 External links
The city's location at the Falls of the Ohio, and its unique position in the central United States (and other origins) to the mouth of the Mississippi River, the Gulf of Mexico, and beyond. The Louisville and Nashville Railroad was also an important link between the industrialized northern cities and the South.
Louisville's importance to the shipping industry continues today with the presence of the Worldport air hub for UPS. The city's location at the crossroads of three major Interstate highways ( I-64, I-65 and I-71) also contributes to its modern-day strategic importance to the shipping and cargo industry. In addition, the Port of Louisville  continues Louisville's river shipping presence at Jefferson Riverport International. As of 2003, Louisville ranks as the seventh-largest inland port in the United States. 
Louisville has emerged as a major center for the health care and medical sciences industries. Louisville has been central to advancements in heart and hand surgery as well as cancer treatment. Some of the first artificial heart and hand transplants were conducted in Louisville. The James Graham Brown Cancer Center is well-renowned. The city's thriving downtown medical research campus includes a new $88 million rehabilitation center and a health sciences research and commercialization park, that in partnership with the University of Louisville, has lured nearly 70 top scientists and researchers.[ citation needed] Louisville is also home to Humana, one of the nation's largest health insurance companies.
Louisville is a significant center of manufacturing. Within the city's limits are two major Ford plants, namely the Kentucky Truck Plant and the Louisville Assembly Plant. Also located in the city is the headquarters and major home appliance factory of GE Appliances (a subsidiary of Haier).
The city is a major center of the American whiskey industry, with about one-third of all bourbon coming from Louisville.     Brown-Forman, one of the major makers of American whiskey, is headquartered in Louisville and operates a distillery in the Louisville suburb of Shively. The current primary distillery site operated by Heaven Hill, called the Bernheim distillery, is also located in Louisville near Brown-Forman's distillery. Other distilleries and related businesses can also be found in neighboring cities in Kentucky, Barton 1792 ( Bardstown), Jim Beam ( Clermont), Wild Turkey ( Lawrenceburg), or Maker's Mark ( Loretto, with a restaurant/lounge in Louisville). Similar to the Kentucky Bourbon Trail that links these central Kentucky locations, Louisville offers tourists its own "Urban Bourbon Trail",  where people can stop at nearly 20 "area bars and restaurants, all offering at least 50 labels of America's only native spirit." 
Craft beer is an increasingly profitable business for the city, home to over 14 locally owned breweries including Bluegrass Brewing Company and Falls City Brewing Company. In 2013 overall beer sales were reported to be down 2% from the previous year, whereas craft beer sales had risen 18%.  To keep up the demand, Mayor Greg Fischer announced in 2015 plans to create "Lou Brew": a tour, similar to the Urban Bourbon Trail, that will highlight the local breweries and craft beer scene of Louisville to both natives and tourists. 
Not typically known for high tech outside of the previously identified industries, Louisville in the 2010s has been at or near the forefront of some high-tech-related developments. In April 2017, Google Fiber confirmed that the city will be wired for its ultrafast network.  Meanwhile, since October 2016, AT&T Fiber has been building out its similar service in the city as well as neighboring counties in Indiana.  Beyond networking, the city, through its public–private partnership called Code Louisville, recognized by President Barack Obama, is aiding area residents in the learning of software coding skills.   
Louisville prides itself in its large assortment of small, independent businesses and restaurants, some of which have become known for their ingenuity and creativity. In 1926 the Brown Hotel became the home of the Hot Brown "sandwich". A few blocks away, the Seelbach Hotel, which F. Scott Fitzgerald references in The Great Gatsby, is also famous for a secret back room where Al Capone would regularly meet with associates during the Prohibition era. The room features a secret back door escape and was used as a starting point for rumrunners who would transport illegal moonshine from the hills of eastern Kentucky to Chicago. Also, in 1880, John Colgan invented a way to make chewing gum taste better for a longer period of time.
The Highlands area of Louisville on Bardstown Road has many independent businesses, including the Preston Arts Center, Baxter Avenue Theater, Carmichael's book store, Heine Brothers' Coffee, John Conti Coffee, Wick's Pizza, Steilberg's String Instruments and O'Shea's Irish Pub, among others. Several local breweries such as Milewide Brewing, Gravely Brewing, Great Flood Brewery, Akasha, Apocolypse, Holsopple, New Albanian Brewery of New Albany, Indiana, Browning's Restaurant and Brewery, Cumberland Brews, and the Bluegrass Brewing Company offer an assortment of local brewing talent in the area.
Louisville has connections to the entertainment industry. Several major motion pictures have also been filmed in or near Louisville, including The Insider, Goldfinger, Stripes, Lawn Dogs, Elizabethtown, Demolition Man, and Secretariat.
Louisville for a long time was also home to the Belknap Hardware and Manufacturing Company, at its peak one of the largest manufacturers and wholesale distributors of hardware in the United States, as well as Brown & Williamson, the third largest company in the tobacco industry before merging with R. J. Reynolds in 2004 to form the Reynolds American Company. Brands such as KOOL, Viceroy, Capri, Misty and Raleigh were introduced in Louisville. Brown & Williamson, one of the subjects of the tobacco industry scandals of the 1990s, was the focus of The Insider, a 1999 film shot around the Louisville area.
- 21c Museum Hotels
- Apriss Inc
- AssuredPartners NL
- Atria Senior Living
- Brown-Forman ( Fortune 1000)
- Crosley Radio
- GE Appliances (subsidiary of Haier)
- Hillerich & Bradsby (manufacturer of Louisville Slugger baseball bats until the division's sale in 2015)
- Hilliard Lyons
- Humana ( Fortune 500)
- Kindred Healthcare (Fortune 500)
- Long John Silver's
- Norton Healthcare
- Papa John's Pizza
- PharMerica (Fortune 1000)
- Presbyterian Church (USA)
- Republic Bank & Trust Company
- Texas Roadhouse
- Tumbleweed Tex Mex Grill & Margarita Bar
- UPS Airlines 
- Yum! Brands (owners of KFC, Pizza Hut, and Taco Bell) (Fortune 500)
- ZFX Inc.
- Business First – Louisville's weekly business newspaper
- Greater Louisville Inc. – Formerly the Louisville Area Chamber of Commerce
- List of major employers in Louisville, Kentucky
- "Port of Louisville". Retrieved April 22, 2017.
- "Top 20 Inland U.S. Ports for 2003" (PDF). U.S. Army Corps of Engineers. Archived from the original (PDF) on January 20, 2013.
- Kiniry, Laura (September 2, 2015). "Beyond bourbon in Louisville". BBC. Retrieved September 29, 2015.
- Lufkin, Bryan (April 29, 2015). "In Louisville, Try the Bourbon and Zip Line (Not at Once)". Wired. Retrieved September 29, 2015.
- "Things to Do in Louisville". Travel Channel. Retrieved September 29, 2015.
- Hall, Gregory A. (October 21, 2014). "Much of bourbon boom carries Louisville address". The Courier-Journal. Retrieved September 29, 2015.
- "Louisville, KY's Urban Bourbon Trail (UBT)". BourbonCounty.com. Retrieved February 20, 2015.
- Puckett, Jeffrey Lee (February 1, 2015). "Beer me: Kentucky's craft beer scene exploding". The Courier-Journal. Retrieved September 30, 2015.
- Leonard, Connie (August 10, 2015). "Mayor announces plan to showcase Louisville's craft beer industry". WAVE. Retrieved September 30, 2015.
- Shafer, Sheldon S. (April 26, 2017). "Google Fiber confirms it will wire Louisville". The Courier-Journal. Retrieved April 26, 2017.
- Sayers, Justin (February 17, 2017). "AT&T Fiber ultrafast internet launched to New Albany, Jeffersonville". The Courier-Journal. Retrieved April 26, 2017.
- "President Obama Wants More Programs Like Code Louisville". 89.3 WFPL.
- "Code Louisville Aims to Expand the Region's Available Tech Talent - 89.3 WFPL". 89.3 WFPL.
- "Why Louisville's Tech Initiatives Are on a National Stage Today". 89.3 WFPL.
"Special Delivery: UPS Moving Ancient Terra Cotta Army".
United Parcel Service. May 5, 2008. Archived from
the original on May 3, 2013. Retrieved 2010-06-19.
UPS air operations are headquartered in Louisville, Ky.