|United Church of Christ|
|Endowment||$108.4 million (2016) |
|Colors||Orange and Black
|NAIA – GPAC,|
The history of Doane University dates from 1857, when the General Association of Congregational Churches, in its first annual meeting in Fremont, Nebraska, resolved to lay the foundations of a literary institution of a high order in the state. Fourteen years later, and after several unsuccessful attempts to establish Congregational schools across the state, an academy was founded in Crete on May 22, 1871. The efforts of Frederick Francis Alley, the local Congregational pastor, and Thomas Doane, chief civil engineer for the Burlington and Missouri River Railroad, were instrumental in advancing the idea of the Academy. 
On July 11, 1872, Doane College preempted the old Crete Academy. On May 9, 2016, the institution was renamed to Doane University. Doane is the first liberal arts and sciences college in Nebraska.
The university has had 67 Fulbright Scholars since the program began in 1946. 
The enrollment consists of over 1,000 undergraduate students on the Crete campus, as well as 750 adult learners and 1,200 graduate students who attend the Lincoln, Omaha and Grand Island campuses.
Doane offers more than 40 undergraduate majors; several pre-professional programs; three graduate programs, and a Doctorate in Education.
Doane University athletic teams, nicknamed the Tigers, are part of the National Association of Intercollegiate Athletics (NAIA), competing in the Great Plains Athletic Conference (GPAC). Men's sports include baseball, basketball, cross country, football, golf, soccer, tennis, track & field and wrestling, while women's sports include basketball, cross country, dance, golf, soccer, softball, tennis, track & field and volleyball. Co-ed sports include cheerleading and shotgun sports.
Doane's football team has participated in three bowl games, winning two and tying one. The first was the 1950 Bean Bowl where they defeated Colorado State College by a score of 14–6. Doane then had back-to-back appearances in the Mineral Water Bowl in 1967 and 1968.  They have qualified for the NAIA National Playoffs five times, most recently in 2015, and were semifinalist in 1972 and 1997.
- Raymonn Adams – running back in Canadian Football League
- Henry Pratt Fairchild – sociologist and educator
- Zenon C.R. Hansen – former chairman of the board at Doane and CEO of Mack Trucks, Inc
- Weldon Kees – poet, painter, filmmaker, and jazz musician
- Dr. Toshihiro Takami '56 – won the Japanese version of the Nobel Peace Prize for his extensive work is sustainable farming in Asia and Africa
- Robert Taylor – actor, star of films from 1930s to '50s
- Ralph W. Tyler '21 – Developed the ACT test
- Robert Van Pelt – judge, U.S. District Court, 1957–88
- John Perry – philosopher and professor of philosophy at Stanford University
- Bob Stitt – football head coach, University of Montana
- Claude E. Welch '27 – Chief surgeon of the Pope rolling the assassination attempt in 1981
- Douglas L. Wilson – two-time recipient of Lincoln Prize and professor at Knox College
- Doane University Historic Buildings, including Gaylord Hall, Boswell Observatory and Whitcomb Conservatory/Lee Memorial Chapel.
- Doane University Osterhout Arboretum
- Frees Hall
- Sheldon Hall
- Hansen Hall
- Smith Hall
- Fiske Lodge
- Dean Memorial Pergola
- Cassel Open Air Theatre, an outdoor theatre designed in 1936 and was named for Doane graduate and former treasurer of the institution, Albert Thomas Cassel. It serves as a location for classes, graduation ceremonies, and on some occasions, weddings.
- Brandt Memorial Bridge
- Porter Memorial Bridge
- Butler Gymnasium
- "U.S. and Canadian Institutions Listed by Fiscal Year 2016 Market Value of Endow" (PDF). NACUBO. Retrieved 24 March 2017.
- Doane University Visual Identity System. Retrieved June 23, 2017.
- "Fulbrights Doane College". Retrieved 10 May 2014.
- DeLassus, David. "Doane Bowl History". College Football Data Warehouse. Archived from the original on July 28, 2014. Retrieved April 9, 2014.