|Motto||"Defy the ordinary"|
liberal arts college |
|United Church of Christ|
|Endowment||$16.8 million (2016) |
|Campus||small town/ rural|
|Colors||Purple and Gold|
|Athletics||NCAA Division III – HCAC|
|Nickname||Yellow Jackets, Lady Jackets|
Defiance College is a very small, highly residential  college in Defiance, Ohio. It is an independent, co-educational liberal arts college affiliated with the United Church of Christ. The campus includes eighteen buildings and access to the 200-acre (80.9 ha) Thoreau Wildlife Sanctuary. 
The college began as Defiance Female Seminary in 1850 and was opened by the Christian Church (Disciples of Christ) to provide schooling for young women. William Curtis Holgate, a local businessman, donated most of the campus. In 1903 the Defiance Female Seminary formally became Defiance College, making it one of only two religious-affiliated colleges to begin operation in Ohio during the 20th century. Much of the institution’s early growth occurred under Peter McReynolds who was named president in 1902. The following years saw growth in students, endowment, and facilities with the addition of most of the original campus buildings.
Defiance College grew and flourished under President Kevin McCann's leadership (1951–1964). Academic programs expanded, and enrollment grew. The physical appearance of the campus changed significantly. The campus increased in size to 140 acres (56.7 ha); the library, student union, and Pilgrim halls were built; and old buildings were renovated. President Dwight D. Eisenhower paid two visits to Defiance College. On October 15, 1953, he laid the cornerstone for Anthony Wayne Library of American Study . He re-visited the campus on May 26, 1963 to deliver the commencement address[ permanent dead link], at which time the college announced that one room in the library had been designated "the Eisenhower Room," honoring the friendship between Eisenhower and Kevin C. McCann.
The Schauffler College of Religious and Social Work in Cleveland had four-year students from more countries than any other, but it failed financially and merged with the graduate school of theology at Oberlin College. When Oberlin closed that school in 1967, the Schauffler endowment was moved to Defiance College, which created the Schauffler Center and later built Schauffler Hall.
- John Ashton, film actor
- Pam Borton, former women's basketball program head coach, University of Minnesota Golden Gophers
- Ben Davis, American footballer, Cleveland Browns defensive back and kick-return specialist
- Esquire Jauchem, producer, director and designer in theater, opera, dance and television
- Richard Mourdock, Treasurer of State, Indiana
- Don Martindale, American football coach, linebackers' coach for the Baltimore Ravens
- Bruce Shingledecker, Alaskan wildlife painter
- North Central Association of Colleges and Schools
- Ohio Board of Regents
- National Council for Accreditation of Teacher Education
- Council on Social Work Education
- Commission on Accreditation of Allied Health Education Programs
- "U.S. and Canadian Institutions Listed by Fiscal Year 2016 Endowment Market Value and Change* in Endowment Market Value from FY2015 to FY2016" (PDF). NACUBO.org. Archived from the original (PDF) on 2017-02-15. Retrieved 25 March 2017.
- "Carnegie Classifications | Institution Lookup". carnegieclassifications.iu.edu. Retrieved 2017-03-26.
- Natural Sciences and Mathematics - Majors - Restoration Ecology