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Christiana Care Health System is a network of private, non-profit hospitals providing health care services to all of the U.S. state of Delaware and portions of seven counties bordering the state in Pennsylvania, Maryland and New Jersey. The system includes two hospitals in Delaware, Wilmington Hospital and Christiana Hospital, as well as the Eugene du Pont Preventive Medicine & Rehabilitation Center, the Helen F. Graham Cancer Center, the Center for Heart & Vascular Health, Visiting Nurse Association and a wide range of outpatient and satellite services. It is headquartered in Wilmington, Delaware.
The system's history dates to 1890, when Delaware Hospital was first opened in Wilmington. It was expanded throughout the subsequent decades. In 1965, it merged with Memorial Hospital and Wilmington General Hospital to form Wilmington Medical Center, with each of the three facilities being known as a "division", thus Delaware Hospital became known as the Delaware Division of the Wilmington Medical Center. Later it was decided to close the other two hospitals and replace them with a new one, Christiana Hospital. In 1985, the Delaware Division was renamed Wilmington Hospital.
In 2014, family medicine physician Dr. Janice E. Nevin, became President and CEO of the health care system.  Under Dr. Nevin, the hospital system focused on excellence and love and focusing on empowering coworkers to speak up about potentially problematic behavior by others in the work environment.  The health care system developed Care Link, a patient centered and clinician-led information technology enhanced care coordination service, that was designed to provide information and scheduling aid in 2017. 
In 2007, Christiana Care saw 457,348 outpatient visits, 55,512 admissions and 7,100 childbirths.  Christiana Care provided $35.7 million in charity care in 2007.  With more than 10,000 employees, it is one of the largest private employers in Delaware and among the top 10 in the greater Philadelphia region.  In 2017 it was reported that the Health Care system was ranked as the 22nd leading hospital and the 11th on the East Coast in terms of admissions. 
Christiana Hospital in Newark, Delaware, is Delaware's only adult Level I trauma center. It was built in 1985 and houses 907 licensed beds  and includes 22 hospital-based operating rooms and 10 outpatient operating rooms. It is home to Delaware's only Level 3 neonatal intensive care unit and the state's largest maternity center, where more than 7,100 newborns are delivered each year. The Christiana Hospital campus is also home to the Center for Heart & Vascular Health and the Helen F. Graham Cancer Center. In 2018, the Hospital opened Delaware's first epilepsy monitoring unit, where doctors attempt to induce a seizure to make a proper diagnosis. 
Wilmington Hospital houses 241 licensed beds and is home to Christiana Care's Center for Rehabilitation and Center for Advanced Joint Replacement. Its campus is also home to the Roxana Cannon Arsht Surgicenter, Wilmington Hospital Health Center, an HIV program and the First State School,  a private/public partnership that provides in-school education for children with serious illnesses that would otherwise render them homebound. Plans for a $250 million expansion project were announced in 2007 that will include room for 90 new patient beds, new operating room suites, an expanded emergency department and much more. 
Christiana Care is a nationally recognized, urban and suburban, academic  and community hospital. The health system have been involved in graduate medical education for over 100 years.
There are over 10 ACGME-accredited residency programs, including Diagnostic Radiology, Emergency Medicine, Family Medicine, General Surgery, Internal Medicine, Obstetrics/Gynecology, Oral & Maxillofacial Surgery, and Podiatry. Christiana Care also offers combined programs, including Emergency Medicine/Family Medicine, Emergency Medicine/Internal Medicine, and Medicine-Pediatrics. Besides residency programs, multiple fellowship programs are also offered by this health system. Other programs include General Practice Dentistry, and Pharmacy.
In regards to medical school affiiliations, Christiana Care is affiliated with The Sidney Kimmel Medical College of the Thomas Jefferson University, and is the largest teaching affiliate hospital for them.[ citation needed] It houses up to 30 medical students, who live and complete their entire third and fourth year curriculum in Delaware. Starting from 2018, Christiana Care started a new affiliation with the Philadelphia College of Osteopathic Medicine to be one of its Clinical campuses for third year medical students with a class size of 11 students.
- Mahoney, Diana (October 2017). "What's Love Got to Do with Health Care? Everything, Says Christiana Care CEO" (PDF). IndustryEdge: 1–3.
- Anderson, Sharon (July 2017). "Innovation Information Technology-Powered Population Health Care Management Improves Outcomes and Reduces Hospital Readmissions and Emergency Department Visits". The Joint Commission Journal on Quality and Patient Safety. 43: 330–337.
- 2008 Christiana Care Facts & Figures
- 2008 100 Top Non-Governmental Employers
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- Ciolino, Nick. "Christiana Care brings epilepsy monitoring unit to First State". Retrieved 2018-09-20.
- Gordon, Thomas P. (February 25, 2016). County set 'Great Women in History Program at Rockwood Park. Office of New Castle County of Delaware County Executive. Retrieved from: https://www.nccde.org/DocumentCenter/View/13543/Great-Women-2016-PR?bidId=
- Chronically Ill Kids Say Learning’s Fun at Health System’s First State School American Hospital Association News June 9, 2008
- "A five-year, $205 million expansion at Christiana Care bodes well for the future"[ permanent dead link]
- "Middletown Free-standing Emergency Department". Christiana Care Health System. Retrieved June 21, 2014.
- Goss, Scott (April 10, 2013). "Christiana Care's Middletown Emergency Department to open next week". Middletown Transcript. Retrieved June 21, 2014.
- Salam, Tabassum (2017). "Christiana Care Health System: Risk Management Strategies for Lower-Extremity Joint Replacements" (PDF). AAMC: 1–2.