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The Central United States is sometimes conceived as between the Eastern and Western United States as part of a three-region model, roughly coincident with the U.S. Census' definition of the Midwestern United States plus the western and central portions of the U.S. Census' definition of the Southern United States. The Central States are typically considered to consist of North Dakota, South Dakota, Nebraska, Kansas, Oklahoma, Texas, Minnesota, Iowa, Missouri, Arkansas, Louisiana, Wisconsin, and Illinois. Sometimes Indiana, Ohio, Kentucky, Tennessee, West Virginia, Mississippi, and Alabama are also considered to be central states.
Almost all of the area is in the Gulf of Mexico drainage basin, and most of that is in the Mississippi Basin. Small areas near the Great Lakes drain into the Great Lakes and eventually the St. Lawrence River; the Red River Basin is centered on the North Dakota- Minnesota border and drains to Hudson Bay.
The Central Time Zone is the same area plus the Florida Panhandle, minus Ohio, most of Michigan, most of Indiana, westernmost fringes of Great Plains states, eastern and northern Kentucky, eastern Tennessee, and El Paso, Texas.
Floods have been a problem for the region during the 20th and early-21st century. 
Census Bureau Divisions with Central in name.
Organizations that need to subdivide the US are free to define a "Central" region to fit their needs.
- YPO Only 6 central states of the Midwest, [a] plus KY
- CERI All of Midwest and South [a] including MD, DE
- NOAA Midwest [a] minus OH, plus KY, CO, WY
- HSUS Midwest [a] minus ND, SD, KS, plus KY
- USGS West North Central States, South Central United States, 4 eastern Mountain States
- Adventure Camp Midwest plus South [a] minus Atlantic states, AL, WV
- Geography of the Interior United States
- National League Central Division, members in PA, OH, WI, IL, MO; TX through 2012
- American League Central Division, members in OH, MI, IL, MN, MO
- National Basketball Association Central Division, members in OH, MI, IN, IL, WI, former members from NC, FL, GA, LA, and Ontario (Canada)
- National Hockey League Central Division, members in CO, MN, TN, TX, IL, MO and Manitoba (Canada), former members in MI, AZ, OH and Ontario (Canada)
- Former National Football Conference Central Division, members in FL, MI, IL, WI, MN
- Former American Football Conference Central Division, members in MD, PA, FL, OH, TN, former member from TX
- See Census definition
- Detailed Tables - American FactFinder
- Iman Mallakpour & Gabriele Villarini (29 September 2014). "The changing nature of flooding across the central United States". Nature Climate Change. Nature. 5: 250–254. doi: 10.1038/nclimate2516. Retrieved 8 November 2015.