The Big Sioux River is a tributary of the Missouri River, 419 miles (674 km) long,  in eastern South Dakota and northwestern Iowa in the United States.  The United States Board on Geographic Names settled on "Big Sioux River" as the stream's name in 1931.  The river was named after the Lakota people (Sioux Indians). 
The Big Sioux River rises in Roberts County, South Dakota  on a low plateau known as the Coteau des Prairies and flows generally southwardly through Grant, Codington, Hamlin, Brookings, Moody, and Minnehaha counties, past the communities of Watertown, Castlewood, Bruce, Flandreau, Egan, Trent, Dell Rapids, and Baltic to Sioux Falls, where it passes over a waterfall in Falls Park, which gives that city its name. Downstream of Sioux Falls and the community of Brandon, the Big Sioux is used to define the boundary between South Dakota and Iowa, flowing along the eastern borders of Lincoln and Union counties in South Dakota, and the western borders of Lyon, Sioux and Plymouth counties in Iowa, past the communities of Canton, Fairview, Hudson, Hawarden, North Sioux City, and Dakota Dunes in South Dakota and Beloit, Hawarden and Akron in Iowa. It joins the Missouri River from the north at Sioux City, Iowa.  
The Big Sioux River collects the Rock River from the northeast in Sioux County, Iowa.  A minor headwaters tributary of the Big Sioux in Grant County, South Dakota, is known as the Indian River.   Broken Kettle Creek has its confluence with the Big Sioux in Plymouth County, Iowa.
The Big Sioux is South Dakota's most populated river basin. Agriculture is the primary use of land along most of the river's course. To comply with the Clean Water Act, the state monitors water quality of its rivers. Most of the Big Sioux north of Sioux Falls was scored well in 2012. Portions near Lake Kampeska and between Willow and Stray Horse Creeks ( Codington and Hamlin counties) exceeded federally allowable levels of E. coli and fecal coliform bacteria. However, the Big Sioux south of Sioux Falls is much more polluted with E. coli, fecal coliform, and suspended solids. Several portions heavily restrict fishing or human contact, and swimming is banned. 
Between 1955 and 1961, an extensive flood control system was constructed by the U.S. Army Corps of Engineers along the Big Sioux and some of its tributaries in Sioux Falls to protect the city from a 100-year flood event.  Features of the system include 29 miles (47 km) of levees, a floodwall in downtown, and a 15,000 feet (4,600 m) diversion channel with a dam at one end and a 118-foot (36 m) spillway at the other.  The diversion channel connects two ends of the Big Sioux's natural loop around central Sioux Falls in an effort to channel floodwater away from the city.  The levees then act to contain any floodwater either remaining in the natural channel or originating from Skunk Creek (whose mouth is downriver of the diversion dam).   Additionally, a greenway covers much of the river's floodplain in southern and eastern Sioux Falls, further mitigating any property damage from high water.
- List of rivers of Iowa
- List of rivers of South Dakota
- Little Sioux River
- Floyd River
- List of river borders of U.S. states
- Blood Run Site — Native American Settlement
- U.S. Geological Survey. National Hydrography Dataset high-resolution flowline data. The National Map Archived 2012-04-05 at WebCite, accessed March 30, 2011
- Columbia Gazetteer of North America entry
- U.S. Geological Survey Geographic Names Information System: Big Sioux River
- Federal Writers' Project (1940). South Dakota place-names, v.3. University of South Dakota. p. 4.
- DeLorme (1998). Iowa Atlas & Gazetteer. Yarmouth, Maine: DeLorme. ISBN 0-89933-214-5
- DeLorme (2001). South Dakota Atlas & Gazetteer. Yarmouth, Maine: DeLorme. ISBN 0-89933-330-3
- U.S. Geological Survey Geographic Names Information System: Indian River
- Andrews, John (March 2013). "Can We Save the Big Sioux?". South Dakota Magazine.
- "Flood Control". City of Sioux Falls. Archived from the original on 2011-01-08. Retrieved 2010-04-19.
- Jorgensen, Don. Sioux Falls diverts water to ease flooding  KELO-TV. March 15, 2010. (accessed April 19, 2010).
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