Asclepias is a genus of herbaceous, perennial, flowering plants known as milkweeds, named for their latex, a milky substance containing cardiac glycosides termed cardenolides, exuded where cells are damaged.    Most species are toxic. The genus contains over 200 species distributed broadly across Africa, North America, and South America.  It previously belonged to the family Asclepiadaceae, which is now classified as the subfamily Asclepiadoideae of the dogbane family Apocynaceae.
Members of the genus Asclepias produce some of the most complex flowers in the plant kingdom, comparable to orchids in complexity. Five petals reflex backwards revealing a gynostegium (fused stamen filamens and styles) surrounded by a five-membrane corona. The corona is composed of a five paired hood and horn structure with the hood acting as a sheath for the inner horn. Glands holding pollinia are found between the hoods. The size, shape and color of the horns and hoods are often important identifying characteristics for species in the genus Asclepias. 
Pollination in this genus is accomplished in an unusual manner. Pollen is grouped into complex structures called pollinia (or "pollen sacs"), rather than being individual grains or tetrads, as is typical for most plants. The feet or mouthparts of flower-visiting insects such as bees, wasps and butterflies, slip into one of the five slits in each flower formed by adjacent anthers. The bases of the pollinia then mechanically attach to the insect, so that a pair of pollen sacs can be pulled free when the pollinator flies off, assuming the insect is large enough to produce the necessary pulling force (if not, the insect may become trapped and die).  Pollination is effected by the reverse procedure, in which one of the pollinia becomes trapped within the anther slit. Large-bodied hymenopterans are the most common and best pollinators, whereas monarch butterflies are not good pollinators of milkweed. 
Asclepias species produce their seeds in pods termed follicles. The seeds, which are arranged in overlapping rows, bear a cluster of white, silky, filament-like hairs known as the coma  (often referred to by other names such as pappus, "floss", "plume", or "silk"). The follicles ripen and split open, and the seeds, each carried by its coma, are blown by the wind. Some, but not all, milkweeds also reproduced by clonal (or vegetative) reproduction.
American milkweeds are an important nectar source for native bees, wasps, and other nectar-seeking insects, though non-native honey bees commonly get trapped in the stigmatic slits and die.   Milkweeds are also the larval food source for monarch butterflies and their relatives, as well as a variety of other herbivorous insects (including numerous beetles, moths, and true bugs) specialized to feed on the plants despite their chemical defenses. 
Milkweeds use three primary defenses to limit damage caused by caterpillars: hairs on the leaves, cardenolide toxins, and latex fluids. Data from a DNA study indicate that more recently evolved milkweed species use these preventative strategies less but grow faster than older species, potentially regrowing faster than caterpillars can consume them.  
Milkweed is not grown commercially in large scale, but the plant has had many uses throughout human history.  The milkweed filaments from the coma (the "floss") are hollow and coated with wax, and have good insulation qualities. During World War II, more than 5,000 t (5,500 short tons) of milkweed floss was collected in the United States as a substitute for kapok.   Milkweed is grown commercially as a hypoallergenic filling for pillows  and as insulation for winter coats. 
A study of the insulative properties of various materials found that milkweed floss was outperformed by other materials in terms of insulation, loft, and lumpiness, but it scored well when mixed with down feathers.  Milkweed fibers are also used to clean up oil spills. 
The bast fibers of some species can be used for rope. Milkweed latex contains about two percent latex and was attempted as a source of natural rubber by both Nazi Germany and the United States during World War II. No record has been found of large-scale success.
Asclepias is also known as "Silk of America"  which is a strand of common milkweed (Asclepias syriaca) gathered mainly in the valley of the Saint Lawrence River in Canada. The silk is used in thermal insulation, acoustic insulation, and oil absorbents.  
Milkweed also contains cardiac glycoside poisons that inhibit animal cells from maintaining a proper K+, Ca+ concentration gradient.  As a result, many natives of South America and Africa used arrows poisoned with these glycosides to fight and hunt more effectively. Milkweed is toxic and may cause death when animals consume large quantities of the plant. Milkweed also causes mild dermatitis in some who come in contact with it. Nonetheless, it can be made edible if properly processed. 
Some Asclepias species:
|Asclepias albicans||Whitestem milkweed, native to the Mojave and Sonoran deserts|
|Asclepias amplexicaulis||Blunt-leaved milkweed, native to central and eastern United States|
|Asclepias asperula||Antelope horns, native to American southwest and northern Mexico|
|Asclepias californica||California milkweed, native to central and southern California|
|Asclepias cordifolia||Heart-leaf milkweed, native to the Sierra Nevada and Cascade Range up to 2000 m.|
|Asclepias cryptoceras||Pallid milkweed, native to the western United States.|
|Asclepias curassavica||Scarlet milkweed, tropical milkweed, bloodflower, bastard ipecacuanha, native to the American tropics, introduced to other continents|
|Asclepias curtissii||Curtiss's milkweed, endemic to sandy areas of Florida|
|Asclepias eriocarpa||Woollypod milkweed, native to California, Baja California, and Nevada|
|Asclepias erosa||Desert milkweed, native to California, Arizona, and Baja California|
|Asclepias exaltata||Poke milkweed, native to eastern North America|
|Asclepias fascicularis||Narrow-leaf milkweed, native to Western United States|
|Asclepias hirtella||Tall green milkweed|
|Asclepias humistrata||Sandhill milkweed, native to southeastern United States|
|Asclepias incarnata||Swamp milkweed, native to wetlands of North America|
|Asclepias lanceolata||Lanceolate milkweed (Cedar Hill milkweed), native to coastal plain of eastern United States from Texas to New Jersey|
|Asclepias linaria||Pine needle milkweed, native to Mojave and Sonoran deserts|
|Asclepias linearis||Slim milkweed|
|Asclepias meadii||Mead's milkweed, native to midwestern United States|
|Asclepias nyctaginifolia||Mojave milkweed, native to the American southwest|
|Asclepias obovata||Pineland milkweed|
|Asclepias purpurascens||Purple milkweed, native to eastern, southern, and midwestern United States|
|Asclepias quadrifolia||Four-leaved milkweed, native to eastern United States and Canada|
|Asclepias rubra||Red milkweed|
|Asclepias solanoana||Serpentine milkweed, native to northern California|
|Asclepias speciosa||Showy milkweed, native to western United States and Canada|
|Asclepias subulata||Rush milkweed, leafless milkweed, native to southwestern North America|
|Asclepias subverticillata||Horsetail milkweed |
|Asclepias sullivantii||Sullivant's milkweed|
|Asclepias syriaca||Common milkweed|
|Asclepias texana||Texas milkweed|
|Asclepias tuberosa||Butterfly weed, pleurisy root|
|Asclepias uncialis||Wheel milkweed|
|Asclepias variegata||White milkweed|
|Asclepias verticillata||Whorled milkweed|
|Asclepias vestita||Woolly milkweed|
|Asclepias viridiflora||Green milkweed|
|Asclepias viridis||Green antelopehorn, spider milkweed|
|Asclepias welshii||Welsh's milkweed|
Species formerly classified under the genus Asclepias include:
- Calotropis gigantea (L.) W.T.Aiton (as A. gigantea L.)
- Calotropis procera (Aiton) W.T.Aiton (as A. procera Aiton)
- Cynanchum louiseae Kartesz & Gandhi (as A. nigra L.)
- Cynanchum thesioides (Freyn) K.Schum. (as A. sibirica L.)
- Funastrum clausum (Jacq.) Schltr. (as A. clausa Jacq.)
- Gomphocarpus cancellatus (Burm.f.) Bruyns (as A. cancellatus Burm.f. or A. rotundifolia Mill.)
- Gomphocarpus fruticosus (L.) W.T.Aiton (as A. fruticosa L.)
- Marsdenia macrophylla (Humb. & Bonpl. ex Willd.) E.Fourn. (as A. macrophylla Humb. & Bonpl. ex Schult.)
- Marsdenia tenacissima (Roxb.) Moon (as A. tenacissima Roxb.)
- Matelea maritima (Jacq.) Woodson (as A. maritima Jacq.)
- Sarcostemma acidum (Roxb.) Voigt (as A. acida Roxb.)
- Sarcostemma viminale (L.) R.Br. (as A. viminalis (L.) Steud.)
- Telosma cordata (Burm.f.) Merr. (as A. cordata Burm.f.)
- Telosma pallida (Roxb.) Craib (as A. pallida Roxb.)
- Tylophora indica (Burm.f.) Merr. (as A. asthmatica L.f.)
- Vincetoxicum hirundinaria Medik. (as A. vincetoxicum L.)
- Vincetoxicum pycnostelma Kitag. (as A. paniculata Bunge)
- Xysmalobium undulatum (L.) R.Br. (as A. undulata L.) 
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