Huh7

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Huh7 is a type of human liver cell line that may be grown in the laboratory for research purposes. According to the web site huh7.com, it is "a well differentiated hepatocyte-derived carcinoma cell line, originally taken from a liver tumor in a 57-year-old Japanese male in 1982."[1] It is used extensively in hepatitis C and dengue virus research.[2][3]

Huh7 cells have been instrumental in hepatitis C research. Until 2005, it was not possible to culture hepatitis C in the laboratory. The introduction of the Huh7 cell line permitted screening of drug candidates against laboratory-cultured hepatitis C virus and permitted the development of new drugs against hepatitis C.[4][2][5]

References[edit]

  1. ^ "HuH-7 Cell Line". Retrieved 2016-07-05.
  2. ^ a b Sainz, Bruno; Tencate, Veronica; Uprichard, Susan L (2009). "Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection". Virology Journal. 6: 103. doi:10.1186/1743-422X-6-103. PMC 2719612. PMID 19604376.
  3. ^ Behnam, Mira A. M.; Nitsche, Christoph; Boldescu, Veaceslav; Klein, Christian D. (2016). "The medicinal chemistry of dengue virus". Journal of Medicinal Chemistry. 59 (12): 5622. doi:10.1021/acs.jmedchem.5b01653. PMID 26771861.
  4. ^ Bartenschlager, R; Pietschmann, T (2005). "Efficient hepatitis C virus cell culture system: what a difference the host cell makes". Proceedings of the National Academy of Sciences of the United States of America. 102 (28): 9739–40. doi:10.1073/pnas.0504296102. PMC 1175013. PMID 15998731.
  5. ^ Meier, Volker; Ramadori, Giuliano (2009). "Hepatitis C virus virology and new treatment targets". Expert Review of Anti-infective Therapy. 7 (3): 329–50. doi:10.1586/eri.09.12. PMID 19344246.

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